Enhanced Elimination of Theophylline, Phenobarbital and Strychnine from the Bodies of Rats and Mice by Squalane Treatment
スポンサーリンク
概要
- 論文の詳細を見る
Our previous study suggested that squalane would be a good candidate for an antidote to reduce the toxicity of drug ingested accidentally at a high dose by enhancing the drug elimination from the body. In the present study, we investigated whether squalane given orally could enhance the elimination of theophylline, phenobarbital and strychnine which were administered parenterally to rats or mice. Squalane increased the fecal excretion of theophylline and reduced the serum level of the drug in rats. Squalane accelerated the fecal excretion of strychnine in mice. These results suggest that squalane may stimulate more the elimination of neutral (theophylline) or basic (strychnine) drugs which should be present in unionized form in intestinal lumen, than that of acidic drugs.
- 公益社団法人日本薬学会の論文
著者
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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Koga N
Department Of Food And Nutrition Nakamura Gakuen University
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Koga Nobuyuki
Faculty Of Pharmaceutical Sciences Kyushu University
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Koga Nobuyuki
九州大学 薬研究院
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Koga Nobuyuki
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Oguri K
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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OGURI Kazuta
Faculty of Pharmaceutical Sciences, Kyushu University
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KAMIMURA Hidetoshi
Faculty of Pharmaceutical Sciences, Kyushu University
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Kamimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)laboratory Of Safety Assessmen
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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Yamada H
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)laboratory Of Safety Assessment Panapharm Laboratories Co. Ltd.:(present Address)department Of Food And Nutrition Nakamura Gakuen College
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Kamimura Hidetoshi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Koga Nobuyuki
Faculty of Nutritional Sciences, Nakamura Gakuen University
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