Role of the Dioxin-like Toxic Compound Coplanar Polychlorinated Biphenyl, 3, 3', 4, 4', 5-Pentachlorobiphenyl in Reducing Hepatic Alcohol Dehydrogenase Levels in Rats in Vivo

概要

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The ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3, 3', 4, 4', 5-pentachlorobiphenyl(PCB126) to reduce the protein level of hepatic class I alcohol dehydrogenase(ADH), which plays an important role in the metabolism of ethanol, was studied. Male Wistar rats received PCB126 25 mg/kgi.p. At this dose the compound induces a wasting syndrome. PCB126 administration resulted in a significant suppression of the protein level of class I ADH, whereas the difference between free- and pair-fed controls was slight. These results suggest that dioxins also reduce class I ADH without involvement of decreased food consumption. These data offer new insights into the toxicity of dioxins via a marked decrease in the level of class I ADH.
公益社団法人日本薬学会の論文
2001-12-01