Involvement of a Novel Mouse Hepatic Microsomal Esterase, ES46.5K, in the Hydrolysis of Phthalate Esters
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概要
- 論文の詳細を見る
ES46.5K, a novel esterase from mouse hepatic microsomes (Watanabe K., et al., Biochem. Mol. Biol. Int., 31,25-30 (1993)), catalyzed hydrolysis of phthalate esters. ES46.5K and mouse hepatic microsomes hydrolyzed diethyl-, dibutyl-, diisobutyl-, dioctyl- and diethylhexyl phthalates, whereas dicyclohexyl- and diphenyl phthalates having ring structure were not hydrolyzed by the enzymes. V_<max> (μmol/min/mg protein)/K_m (μM) ratios of ES46.5K for diethyl-, dibutyl-, diisobutyl-, dioctyl- and diethylhexyl phthalates were 291,2786,565,51 and 57,respectively, while those of microsomes were 0.58,0.83,1.71,0.05 and 1.10,respectively. The hydrolytic activity of ES46.5K was inhibited by diisopropylfluorophosphate and bis-p-nitrophenylphosphate. These results suggest that ES46.5K has high catalytic activity for phthalate esters and some role in the metabolism of phthalate esters in mice.
- 社団法人日本薬学会の論文
- 1997-07-15
著者
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YAMAMOTO IKUO
Department of Laboratory Medicine, Miyazaki Medical College
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Yamamoto Ikuo
Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W
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Watanabe Kazuhito
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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MATSUNAGA Tamihide
Department of Pharmacy, Shinshu University Hospital
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YOSHIMURA Hidetoshi
Department of Food and Nutrition, Nakamura Gakuen University
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Yamamoto Ikuo
北陸大学 薬 衛化
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Yamamoto Ikuo
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Kayano Yuichiro
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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YAMAMOTO IKUO
Hygienic Chemistry
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Kayano Y
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Kayano Yuichiro
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Watanabe Kazuhito
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Watanabe Kazuhito
Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Yoshida H
Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.
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Yamamoto I
Hygienic Chemistry
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Yoshida Hiromi
Department Of Nutritional Science Kobe Gakuin University
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Matsunaga Tamihide
Department Of Pharmacy Shinshu University Hospital
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen
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Yamamoto Ikuo
Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University
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Matsunaga Tamihide
Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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