Cross-Reactivity of Various Tetrahydrocannabinol Metabolites with a Monoclonal Antibody against Tetrahydrocannabinolic Acid

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概要

• 論文の詳細を見る

• A monoclonal antibody (MAb-4A4) against Δ^9-tetrahydrocannabinolic acid (THCA) was prepared and its cross-reactivity analyzed with various cannabinoids including tetrahydrocannabinol metabolites by competitive enzyme-linked immunoassay (ELISA). Δ^9-THC (1-100μg/ml) could be determined by the ELISA. Many metabolites of Δ^8-THC and Δ^9-THC reacted with the antibody, and their cross-reactivities were 44-157% of Δ^8-THC. However, the antibody did not recognize the lipophilic compounds cholesterol, testosterone, β-carotene, androstene-3,17-dione or an endogenous cannabinoid, anandamide.

• 社団法人日本薬学会の論文
• 2000-08-01

著者

• Tanaka Hiroyuki

  Department Of Cardiology Kurashiki Central Hospital

• YAMAMOTO IKUO

  Department of Laboratory Medicine, Miyazaki Medical College

• 景山 節

  京大・霊長類研・生化学

• Yamamoto Ikuo

  Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W

• Kimura Toshiyuki

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• Watanabe Kazuhito

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• MATSUNAGA Tamihide

  Department of Pharmacy, Shinshu University Hospital

• YAMAMOTO Ikuo

  School of Pharmaceutical Sciences, Kyushu University of Health and Welfare

• Matsuda Midori

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• MIKI Masaaki

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• Tateoka Yuji

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• Shoyama Yukihiro

  Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University

• 舘岡 裕二

  Shinshin Chemical Industry Co. Ltd.

• Yamamoto Ikuo

  北陸大学 薬 衛化

• Yamamoto Ikuo

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• YAMAMOTO IKUO

  Hygienic Chemistry

• Miki M

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Kimura T

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• 景山 節

  京都大学霊長類研究所人類進化モデル研究センター

• 景山 節

  京大・霊長研

• Kimura Toshiyuki

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Watanabe Kazuhito

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Watanabe Kazuhito

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University

• Tanaka H

  Department Of Medicinal Plants Breeding And Pharmacognosy Graduate School Of Pharmaceutical Sciences

• Kimura T

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Tateoka Yuji

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Yamamoto I

  Hokuriku Univ. Kanazawa Jpn

• Tanaka Hiroyuki

  Department Of Medicinal Plants Breeding And Pharmacognosy Graduate School Of Pharmaceutical Sciences

• Yamamoto I

  Hygienic Chemistry

• Shoyama Y

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagasaki International University

• Shoyama Yukihiro

  Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyushu University

• Matsunaga Tamihide

  Department Of Pharmacy Shinshu University Hospital

• Watanabe Kazuhito

  Faculty Of Pharmaceutical Sciences Kyushu University

• Yamamoto Ikuo

  Hygienic Chemistry School Of Pharmacy Hokuriku University

• Shoyama Yukihiro

  Department Of Forestry Faculty Of Agriculture Kyushu University

• Yamamoto Ikuo

  Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University

• Tanaka Hiroyuki

  Department Of Anesthesia And Clinical Research Institute National Hospital Organization Kyushu Medic

• Kimura T

  Peptide Inst. Inc. Minoh Jpn

• SHOYAMA Yukihiro

  Department of Chemo-Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kyushu University

• Matsunaga Tamihide

  Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University

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