The Effect of a Newly Synthesized Indazole Compound, TAS-3-124, on Experimental Autoimmune Disease(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of a newly synthesized compound, 6-acetoamido-1-acetyl-1-indazole (TAS-3-124), on autoimmune diseases were studied. We used animal models of collagen-induced arthritis (CIA) in mice and experimental autoimmune encephalomyelitis (EAE) in rats to evaluate the efficacy of TAS-3-124. TAS-3-124 at doses of 100 and 300 mg/kg p.o. inhibited the development of CIA, decreasing the swelling of fore- and hind-limbs and bone destruction in knee joints. This agent also suppressed the delayed type hypersensitivity reaction (DTH) against type II collagen. These effects were confirmed by histopathological examination and measurement of the expression of mRNA of proinflammatory cytokines in the knee joint. In addition, TAS-3-124 at a dose of 300 mg/kg inhibited the development of EAE and the DTH to myelin basic protein (MBP) in rats. Moreover, TAS-3-124 inhibited the production of proinflammatory cytokines including interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6 but not T cell derived cytokines in mice. These demonstrate the efficacy of TAS-3-124 against experimental autoimmune disease, probably due to the suppression of the production of proinflammatory cytokines in the pathological lesion.
- 社団法人日本薬学会の論文
- 2004-08-01
著者
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Tanaka Hiroyuki
Department Of Cardiology Kurashiki Central Hospital
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Nagai H
Department Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
富山医科薬科大学和漢薬研究所
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Nii Hiroaki
岐阜薬科大学 薬理学
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Takeda H
Department Of Pharmacology Gifu Pharmaceutical University
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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AKABANE Hirotomo
Department of Pharmacology, Gifu Pharmaceutical University
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MIYAGAWA Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NII Hiroaki
Department of Pharmacology, Gifu Pharmaceutical University
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INAMI Yoshihiro
Department of Pharmacology, Gifu Pharmaceutical University
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TOGAWA Michinori
Pharmacological Research Center, Taiho Pharmaceutical Company
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Imai Yoshiko
Department Of Pharmacology Gifu Pharmaceutical University
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Inami Yoshihiro
岐阜薬科大学 薬理学
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Inami Yoshihiro
Department Of Pharmacology Gifu Pharmaceutical University
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Inagaki Naoki
Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University
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Miyagawa Naoki
Central Pharmaceutical Research Institute Japan Tobacco Inc.
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Miyagawa Naoki
岐阜薬科大学 薬理学
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Miyagawa Naoki
Department Of Pharmacology Gifu Pharmaceutical University
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Togawa Michinori
Pharmacological Research Center Taiho Pharmaceutical Company
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Togawa Michinori
岐阜薬科大学 薬理学
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Timmerman Henk
Leiden/amsterdam Center For Drug Research Division Of Medicinal Chemistry Vrije University
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Nojima H
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Inagaki N
Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University
-
Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Inagaki Naoki
Department Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Lab. Of Clinical Pharmacology Gifu Pharmaceutical Univ.
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Nagai Hiroichi
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Nojima Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Ohu University
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Nojima H
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Miyagawa Naoki
Department Of Orthopedic Surgery Tokyo Medical University
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Akabane Hirotomo
Department Of Pharmacology Gifu Pharmaceutical University
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Nii Hiroaki
Department Of Pharmacology Gifu Pharmaceutical University
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Nojima Hiroshi
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Takeda Hiroshi
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Tanaka Hiroyuki
Department Of Anesthesia And Clinical Research Institute National Hospital Organization Kyushu Medic
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Tsuchiya Hiroshi
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Tanaka Hiroyuki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Inagaki Naoki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Information Science Gifu University
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Inami Yoshihiro
Department Of Gastroenterology Juntendo University School Of Medicine
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Inami Yoshihiro
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
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