Effect of Antiallergic Drugs on Interleukin 5-Induced Eosinophil Infiltration of Rat Airways
スポンサーリンク
概要
- 論文の詳細を見る
Interleukin (IL)-5 is thought to play important roles in asthma and to be a potential therapeutic target. An intratracheal injection of murine recombinant IL-5 (3-30 μg/animal) induced a dose-dependent increase in the number of eosinophils in the bronchoalveolar lavage fluid of Brown Norway (BN) rats 24h after administration. Bovine serum albumin (30μg/animal), used as reference material, did not cause any change. The reaction was not observed in F344 rats. The increase in the number of eosinophils did not accompany bronchial hyperreactivity in BN or F344 rats. Prednisolone (3-10mg/kg, i.p.) and emedastine (30mg/kg, p.o.) reduced the increased number of eosinophils induced by the IL-5 challenge. These results suggest that IL-5 is a potent inducer of eosinophils in the airway of BN rats. Prednisolone and emedastine are effective against IL-5-induced eosinophilia.
- 社団法人日本薬学会の論文
- 2002-03-01
著者
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Tanaka Hiroyuki
Department Of Cardiology Kurashiki Central Hospital
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Takeda H
Department Of Pharmacology Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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TAKIZAWA Toshiaki
Department of Pharmacology, Gifu Pharmaceutical University
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Takizawa Toshiaki
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Takizawa Toshiaki
興和
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Takizawa Toshiaki
岐阜薬科大学 薬理
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KAWADA Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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Timmerman Henk
Leiden/amsterdam Center For Drug Research Division Of Medicinal Chemistry Vrije University
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Takizawa Toshiaki
Department Of Neurosurgery Central Hospital Of Japaneae National Railways
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Nishida Hiroyuki
Department Of Pharmacology Gifu Pharmaceutical University
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Takeda Hiroshi
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Tanaka Hiroyuki
Department Of Anesthesia And Clinical Research Institute National Hospital Organization Kyushu Medic
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Tsuchiya Hiroshi
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
-
Tanaka Hiroyuki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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