Synthesis of N^3-Substituted Uridine and Related Pyrimidine Nucleosides and Their Antinociceptive Effects in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Seventy eight N^3-substituted derivatives of uridine (1), thymidine (2), 2'-deoxyuridine (3), 6-azauridine (4), 2', 3'-O-isopropylideneuridine (5), and arabinofuranosyluracil (6) were synthesized and their antinociceptive effects were evaluated. N^3-(2', 4'-Dimethoxyphenacyl)uridine (1l), N^3-(2', 4'-dimethoxyphenacyl)2'-deoxyuridine (3l), and N^3-(2', 5'-dimethoxyphenacyl)arabinofuranosyluracil (6m) possessed 93, 86, and 82% of the antinociceptive effects tested by hot plate, respectively. The antinociceptive effects of three derivatives were 5.8, 5.4, and 5.1-folds of the effect of N^3-phenacyluridine (1h)(16%), respectively. The structure-activity relationship of N^3-substituted pyrimidine nucleosides was also discussed.
- 社団法人日本薬学会の論文
- 2005-03-01
著者
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景山 節
京大・霊長類研・生化学
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Yamamoto Ikuo
Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W
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Watanabe Kazuhito
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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FUNAHASHI Tatsuya
Faculty of Pharmaceutical Sciences, Okayama University
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WATANABE Kazuhito
Faculty of Pharmaceutical Sciences, Hokuriku University
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KIMURA Toshiyuki
Faculty of Pharmaceutical Sciences, Hokuriku University
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YAMAMOTO Ikuo
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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SHIMIZU Tomomi
Faculty of Pharmaceutical Sciences, Hokuriku University
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HO Ing
University of Mississippi Medical Center
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Yamamoto Ikuo
北陸大学 薬 衛化
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YAMAMOTO IKUO
Hygienic Chemistry
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Kimura T
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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景山 節
京都大学霊長類研究所人類進化モデル研究センター
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景山 節
京大・霊長研
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Ho Ing
ミシシッピ大学医学部薬毒理学教室
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Watanabe Kazuhito
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Funahashi Tatsuya
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Funahashi Tatsuya
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
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Kimura Toshiyuki
Faculty Of Engineering Yokohama National University
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Yamamoto I
Hokuriku Univ. Kanazawa Jpn
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Shimizu Tomomi
Faculty Of Pharmaceutical Sciences Hokuriku University
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto I
Hygienic Chemistry
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto Ikuo
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Yamamoto Ikuo
Hygienic Chemistry School Of Pharmacy Hokuriku University
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Kimura T
Peptide Inst. Inc. Minoh Jpn
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