カテプシンEの構造と機能--プロセシング酵素としての可能性
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概要
著者
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景山 節
京大・霊長類研・生化学
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景山 節
京都大学霊長類研究所人類進化モデル研究センター
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景山 節
京大・霊長研
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Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
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Kimura T
Peptide Inst. Inc. Minoh Jpn
関連論文
- ペプシノーゲンの活性科機構(生理学)
- ニホンツキノワグマのペプシノーゲンとペプシンの精製および霊長類との比較検討(生化学)
- ペプシノーゲンの活性化ペプチドの一次構造にもとづく霊長類の系統-II. : ヒトとニホンザルの分岐(分類・系統学)
- カンナビノイドの代謝的活性化とシトクロムP450分子種
- Butyrylcholinesterase and Erythrocyte Sulfhydryl-dependent Enzyme Hydrolyze Gabexate in Human Blood
- Involvement of Human Blood Arylesterases and Liver Microsomal Carboxylesterases in Nafamostat Hydrolysis
- Development of New Photoresponsive Paclitaxel Prodrug
- Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
- "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
- サル腎ミクロソームによるTetrahydrocannabinolの代謝
- Design and Synthesis of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity
- Controlled Drug Release : Design and Application of New Water-soluble Prodrugs
- Spontaneously Regenerable Prodrug : Design and Synthesis of Water-soluble Prodrugs of HIV Protease Inhibitors
- Design of Double-Drug-Type Anti-HIV Agents
- New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor
- Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor
- Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker
- Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
- The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
- Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
- P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT"
- Conversion of Polymer-Bound Dipeptide to Evans-Type Chiral Auxiliary : A New Tool for Efficient Solid-Phase Asymmetric Reactions
- サル肝ミクロソーム酵素によるレチナールからレチノイン酸への代謝
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- Stereospecific and Regioselective Hydrolysis of Cannabinoid Esters by ES46.5K, an Esterase from Mouse Hepatic Microsomes, and Its Differences from Carboxylesterases of Rabbit and Porcine Liver(Biochemistry)
- In Vitro Inhibitory Effects of Cannabinoids on Progesterone 17α-Hydroxylase Activity in Rat Testis Microsomes
- Synthesis of N^3-Substituted Uridine and Related Pyrimidine Nucleosides and Their Antinociceptive Effects in Mice
- Major Cytochrome P450 Enzymes Responsible for Microsomal Aldehyde Oxygenation of 11-Oxo-〓^8-tetrahydrocannabinol and 9-Anthraldehyde in Human Liver
- Skin Reaction Induced by Aldehydes for Food Flavoring Agents
- Possible Existence of a Novel Receptor for Uridine Analogues in the Central Nervous System Using Two Isomers, N^3-(S)-(+)-and N^3-(R)-(-)-α-Hydroxy-β-phenethyluridines
- Hypnotic Action of N^3-Substituted Arabinofuranosyluracils on Mice
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- A Carbonyl Reductase-Catalyzing Reduction of N^3-Phenacyluridine in Rabbit Liver
- Synthesis and Pharmacological Evaluation in Mice of Halogenated Cannabidiol Derivatives.
- Synthesis and Central Nervous System Depressant Effects of N^3-Substituted 2', 3'-O-Isopropylideneuridines
- Synthesis and Pharmacological Evaluation in Mice of Halogenated Cannabidiol Derivatives
- Pharmacologica Efects in Mice of Anandamide and Its Related Fatty Acid Ethanolamides, and Enhancement of Cataleptogenic Effect of Anandamide by Phenylmethylsulfonyl Fluoride
- Synthesis and Pharmacological Activities in Mice of Halogenated Δ^9-Tetrahydrocannabinol Derivatives
- Synthesis and Sedative-Hypnotic Effects of N^3-Allyl-and N^1-Allyl-5,6-substituted 2-Thiouracil Derivatives in Mice
- Defective Myosin Genes in Mutant Mice and Human Diseases
- カテプシンD, Eの切断特異性とインヴァリアント鎖のプロセシング
- カイコ卵の Malic enzyme : その精製と性質(生化学)
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- Effective NADH-Dependent Oxidation of 7β-Hydroxy-Δ^8-tetrahydrocannabinol to the Corresponding Ketone by Japanese Monkey Hepatic Microsomes(Toxicology)
- Monkey Hepatic Microsomal Alcohol Oxygenase: Purification and Characterization of a Cytochrome P450 Enzyme Catalyzing the Stereoselective Oxidation of 7α-and 7β-Hydroxy-Δ^8-tetrahydrocannabinol to 7-Oxo-Δ^8-tetrahydrocannabinol
- Stereoselectivity in Bunitrolol 4-Hydroxylation in Liver Microsomes from Marmosets and Japanese Monkeys
- Microsomal Aldehyde Oxygenase (MALDO): Purification and Characterization of a Cytochrome P450 Isozyme Responsible for Oxidation of 9-Anthraldehyed to 9-Anthracenecarboxylic Acid in Monkey Liver
- Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. II. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having N, N-Dialkylaminoalkoxycarbonyl Groups at 3- and/or 5-Position
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3- and/or 5-Position
- Compertitive Inhibition of Δ^8-Tetrahydrocannabinol and Its Active Metabolites for Cannabinoid Receptor Binding
- Anandamide, an Endogenous Cannabinoid Receptor Ligand, Also Interacts with 5-Hydroxytryptamine (5-HT) Receptor
- ペプシノ-ゲン酵素群の構造と発達過程における発現機構
- 昆虫の休眠と糖代謝
- ヒメシロモンドクガ休眠・非休眠卵の比較(内分泌・遺伝)
- カイコ卵のリンゴ酸脱水素酵素(生化学)
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- 霊長類における胃内タンパク消化酵素ペプシノゲンの多様化
- New World Monkey Pepsinogens A and C, and Prochymosins. Purification, characterization of Enzymatic Properties, cDNA Cloning, and Molecular Evolution
- カテプシンEの構造と機能--プロセシング酵素としての可能性
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- Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs
- Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
- Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
- Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
- Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
- P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION
- Modification of P4 Position in β-secretase (BACE1) Inhibitors Containing Phenylnorstatine
- Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
- Evaluation of Peptidomimetic HTLV-I Protease Inhibitors Containing Hydroxymethylcarbonyl as a Transition-State Isostere
- O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants
- Design and Synthesis of β-Secretase Inhibitors Containing Hydroxymethylcarbonyl Isostere as a Transition State Mimic
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- STRUCTURE-ACTIVITY RELATIONSHIP OF URIDINE DERIVATIVES FOR HYPNOTIC ACTIVITY
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- Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization
- SAR study of BACE1 inhibitors containing pyridine derivatives
- Chemical Synthesis of 71-meric Neuregulin 1-β1
- Gastric digestive proteinases of the greater horseshoe bat, Rhinolophus ferrumequinum
- Pepsinogens and Pepsins from House Musk Shrew, Suncus murinus: Purification, Characterization, Determination of the Amino-Acid Sequences of the Activation Segments, and Analysis of Proteolytic Specificities^1
- Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
- "O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42
- Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method
- A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection
- Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin
- Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability
- Histidine-Related Dipeptides, Carnosine, Anserine and Homocarnosine, Possess the CNS Depressant Effects on Mice and their Action Mechanism
- Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
- Optimization of Peptidomimetic Plasmepsin Inhibitor Containing Allophenylnorstatine Using Basic Substituent for Malaria Treatment
- Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
- Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
- Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
- Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
- INTERACTIONS OF ACTIVE CANNABINOID METABOLITES WITH GABA_A RECEPTOR