Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. II. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having N, N-Dialkylaminoalkoxycarbonyl Groups at 3- and/or 5-Position
スポンサーリンク
概要
- 論文の詳細を見る
Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N, N-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylate, I-43 (CS-905), exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.
- 公益社団法人日本薬学会の論文
- 1995-05-15
著者
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井上 哲也
Faculty Of Pharmaceutical Sciences Osaka University
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Kobayashi T
Faculty Of Science Shinshu University
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木村 富美夫
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
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大泉 喜代志
Sankyo Biological Research Laboratories, Sankyo Co., Ltd.
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井上 勗
Ohmiya Research Laboratory Fuji Yakuhin Co. Ltd.
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Inoue T
Ohmiya Research Laboratory Fuji Yakuhin Co. Ltd
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Kawanishi T
大妻女子大学 食物学科
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古林 隆司
Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries
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井上 輝比古
Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries
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西野 繁栄
Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries
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藤原 義巳
Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries
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西野 重孝
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nishino S
Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn
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Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
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西野 繁栄
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
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Inoue T
Osaka University Of Pharmaceutical Sciences
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井上 輝比古
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
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大泉 喜代志
Sankyo Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.
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Oizumi K
Sankyo Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.
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大泉 喜代志
Sankyo Biological Research Laboratories Sankyo Co. Ltd.
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藤原 義巳
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
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Inoue Takao
Faculty Of Pharmaceutical Sciences Hoshi University
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Kimura T
Peptide Inst. Inc. Minoh Jpn
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