RENAL MICROSOMAL N-NITROSODIMETHYLAMINE DEMETHYLASE DETERMINED BY A SENSITIVE RADIOMETRIC METHOD
スポンサーリンク
概要
- 論文の詳細を見る
Renal Microsomal N-nitrosodimethylamine (NDMA) N-demethylation was measured in several species by a sensitive radiometric method using [^<14>C] NDMA as a substrate and 2,4-dinitrophenylhydrazine (DNPH) as a trapping agent of the [^<14>C] formaldehyde formed. The activities were the highest in mice and lowest in hamsters. The activities in rats could not be detected. Among several strains of mice studied the DDY strain was the highest in its activities. Although nicotinamide adenine dinucleotide supported NDMA demethylation by about 32% of nicotinamide adenine dinucleotide phosphate in kidney and only 16% in liver, other properties (pH profiles, k_m values, and effects of inhibitors) exhibited almost similar results in liver as compared to kidney.
- 公益社団法人日本薬学会の論文
著者
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Ohe Yuichiro
国立医薬品食品衛生研究所
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Ohe Yuichiro
Department Of Medical Oncology National Cancer Center Hospital
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TAKANAKA Akira
Division of Pharmacology, BSRC, National Institute of Hygienic Sciences
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Ohno Yasuo
Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences
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Kawanishi Toru
Div. Of Drugs National Inst. Of Health Sci. Jpn
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Kawanishi T
大妻女子大学 食物学科
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Takahashi Atsushi
Division Of Pharmacology National Institute Of Hygienic Sciences
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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OMORI Yoshihito
Division of Pharmacology, Biological Safty Research Centet, National Institute of Hygienic Sciences
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Kasuya Y
Hoshi Univ. Tokyo Jpn
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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TAKANAKA Akira
The Organization for Pharmaceutical Safety and Research
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Takanaka Akira
Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences
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Takanaka A
National Inst. Hygienic Sciences Tokyo Jpn
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Kawanishi Toru
Division Of Pharmacology National Institute Of Hygienic Sciences
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Omori Yoshihito
Division Of Pharmacology Biological Safety Research Center National Institute Of Hygienic Sciences:d
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Takahashi A
Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences
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