COMPARISONS OF THE TOXICOKINETIC PARAMETERS IN RATS DETERMINED FOR LOW AND HIGH DOSE OF γ-CHLORDANE

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概要

• 論文の詳細を見る

• Toxicokinetic parameters of γ-chlordane (GCD) after oral administration of various doses of radio-rabelled GCD (50μg/kg-10 mg/kg) were compared. Absorption of GCD were about 80% in both 0.1 and 1.0 mg/kg groups. Distributions of GCD (50μg/kg and 10 mg/kg) into the liver and kidney were rapid and those into adipose tissues were relatively slow. Concentrations of GCD in adipose tissues became highest at 16 hr after administration and became about 10 times more than those in the liver. The initialconcentrations of GCD calculated by two-compartment open model in high dose group (10 mg/kg) were about 200-300 times higher than those in low dose group (50μg/kg). Half lives of GCD in low dose group had a tendency to be a little longer than those in high dose group. This difference seemed to be caused by the accumulation of oxychlordane in low dose group.

• 日本トキシコロジー学会の論文
• 1986-05-25

著者

• OHNO Yasuo

  Division of Pharmacology, National Institute of Health Science

• Ohe Yuichiro

  国立医薬品食品衛生研究所

• Ohe Yuichiro

  Department Of Medical Oncology National Cancer Center Hospital

• Kawashima Kunio

  Division of Toxicology, National Institute of Health Sciences

• Tanaka Satoru

  Division of Toxicology, National Institute of Health Sciences

• TAKANAKA Akira

  Division of Pharmacology, BSRC, National Institute of Hygienic Sciences

• TANAKA Satoru

  Toxicology Laboratory, Kissei Pharmaceutical Co., Ltd.

• Takahashi Atsushi

  Division of Electrical, Electronic and Information Engineering, Osaka University

• KAWANISHI Toru

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• Ohno Yasuo

  Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences

• Kawanishi Toru

  Div. Of Drugs National Inst. Of Health Sci. Jpn

• Kawanishi T

  大妻女子大学 食物学科

• Kawanishi T

  Division Of Drugs National Institute Of Health Science

• Kawanishi Toru

  Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences

• Kitaura K

  Univ. Tokushima School Of Medicine Tokushima

• Kitaura Keisuke

  Second Department Of Pathology The University Of Tokushima School Of Medicine

• Takahashi Atsushi

  Division Of Pharmacology National Institute Of Hygienic Sciences

• NAKAURA Shinsuke

  Division of Pharmacology, Biological Safty Research Centet, National Institute of Hygienic Sciences

• OMORI Yoshihito

  Division of Pharmacology, Biological Safty Research Centet, National Institute of Hygienic Sciences

• Tanaka Satoru

  Division Of Pharmacology National Institute Of Hygienic Sciences

• KOBAYASI TADASHI

  Kobe Pharmaceutical University

• Kawanishi Toru

  Division Of Drugs National Institute Of Health Science

• Kawanishi Toru

  国立医薬品食品衛生研究所

• Sekita H

  Nec Corp. Kanagawa Jpn

• TAKANAKA Akira

  The Organization for Pharmaceutical Safety and Research

• Tanaka S

  Toxicology Laboratory Kissei Pharmaceutical Co. Ltd.

• Takanaka Akira

  Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences

• Takanaka A

  National Inst. Hygienic Sciences Tokyo Jpn

• Kawanishi Toru

  Division Of Pharmacology National Institute Of Hygienic Sciences

• SEKITA Hiroshi

  Division of Pharmacology, National Institute of Hygienic Sciences

• UCHIYAMA Mitsuru

  Division of Drugs, National Institute of Hygienic Sciences

• Kawashima Kunio

  Division Of Pharmacology National Institute Of Hygienic Sciences

• Kawashima Kunio

  Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences

• Sekita Hiroshi

  Division Of Pharmacology National Institute Of Hygienic Sciences

• Omori Yoshihito

  Division Of Pharmacology Biological Safety Research Center National Institute Of Hygienic Sciences:d

• Uchiyama Mitsuru

  Division Of Drugs National Institute Of Hygienic Sciences

• Nakaura Shinsuke

  Biosafety Research Center Food Drugs And Pesticides

• Tanaka Satoru

  Division Of Internal Medicine Shizuoka City Hospital

• Takahashi Atsushi

  Division Of Electrical Electronic And Information Engineering Osaka University

• Ohno Yasuo

  Division Of Internal Medicine And Thoracic Oncology National Cancer Center Hospital

• Takahashi A

  Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences

• Kawashima Kunio

  Division Of Biological Evaluation National Institute Of Health Science Osaka Branch

• Tanaka Satoru

  Division Of Internal Medicine And Thoracic Surgery Shizuoka City Hospital

• Kawashima Kunio

  Department Of Pathology National Institute Of Health Sciences

• Takayama Satoshi

  Research Department Saitama Daiichi Pharmaceutical Co. Ltd. Japanese Pharmaceutical Manufacturers Association

• Takahashi Atsushi

  Division Of Electrical Electronic And Information Engineering Graduate School Of Engineering Osaka University

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