COMPARATIVE TOXICOKINETIC STUDY OF RUBBER ANTIOXIDANTS, 2-MERCAPTOBENZIMIDAZOLE AND 2-MERCAPTOMETHYLBENZIMIDAZOLE, BY SINGLE ORAL ADMINISTRATION IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Toxicokinetics of 2-mercaptobenzimidazole (MBI) and 2-mercaptomethylbenzimidazole (MMBI), rubber antioxidants with thioureylene structure, were compared after single oral administration in rats. Male Wistar rats received single oral administration of 2, 10, 50 and 250 mg/kg of MBI or MMBI. The serum and urine concentrations of MBI and MMBI were determined by HPLC. MBI and MMBI showed similar Cmax values, but the former disappeared slower in the serum than the latter and resulted in its larger AUC values. Analyses of MBI, MMBI and their desulfurated metabolites in urine suggested that these differences were due to their metabolic elimination rates. On the other hand, MBI and MMBI caused similar acute toxicities, such as loss of locomotive activity, ataxic gait, adoption of prone or side position and coma, being severer with higher serum concentrations at the moment. Similar acute toxicities between MBI and MMBI were explained by similar Cmax values at the same dose. It was suggested from these results that the slower disappearance and larger AUC values of MBI in the serum compared to MMBI might explain the strong thyroid toxicity which has been observed by repeated administration of MBI, but very weak thyroid toxicity by MMBI.
- 日本トキシコロジー学会の論文
- 1999-12-20
著者
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Kitajima Satoshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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OHNO Yasuo
Division of Pharmacology, National Institute of Health Science
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Ohe Yuichiro
国立医薬品食品衛生研究所
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Ohe Yuichiro
Department Of Medical Oncology National Cancer Center Hospital
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SAKEMI Kazue
Division of Pharmacology, National Institute of Health Sciences
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TSUDA Mitsuhiro
Division of Pharmacology, National Institute of Health Sciences
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Ohno Y
Division Of Pharmacology National Institute Of Health Sciences
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Ohno Yasuo
Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences
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Ueda Makoto
Division Of Pathology National Institute Of Health Sciences
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Sakemi Kazue
Division Of Pharmacology National Institute Of Health Sciences
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Usami Makoto
Division of Pharmacology, National Institute of Health Sciences
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Tsuda Mitsuhiro
Division Of Pharmacology National Institute Of Health Sciences
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Sakemi K
Division Of Pharmacology National Institute Of Health Sciences
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Sakemi Kazue
Division Of Pharmacology And Biological Safety Research Center National Institute Of Health Sciences
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Sakemi Kazue
Division Of Pharmacology National Institute Of Hygienic Sciences
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Tsuda Mitsuhiro
Div.of Toxicology
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Tsuda Mitsuhiro
Division Of Pharmacology And Biological Safety Research Center National Institute Of Health Sciences
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Usami Makoto
Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences
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MITSUNAGA Katsuyoshi
Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences
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Mitsunaga Katsuyoshi
Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences
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Omori Yoshihito
Division Of Pharmacology National Institute Of Hygienic Sciences
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Ohno Yasuo
National Inst. Of Health Sci. Tokyo Jpn
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Usami M
Division Of Pathology National Institute Of Health Sciences
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Ohno Yasuo
Division Of Internal Medicine And Thoracic Oncology National Cancer Center Hospital
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Usami Makoto
Division Of Pathology National Institute Of Health Sciences
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Usami Makoto
Division of Nutrition and Metabolism, Department of Biophysics, Kobe University Graduate School of Health Sciences
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