EFFECTS OF KOJIC ACID ON THYROIDAL FUNCTIONS IN RATS BY SINGLE-DOSE ADMINISTRATION AND IN CULTURED RAT THYROID CELLS (FRTL-5 CELLS)
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概要
- 論文の詳細を見る
The effects of kojic acid (KA) on thyroidal function were studied by single-dose administration in rats and in cultured rat thyroid cells (FRTL-5 cells). In rats receiving a single dose of 1,000 mg/kg KA orally, the ^125I uptake from blood into the thyroid gland was significantly lower than that of the control group from 30 min to 24 hr after administration. The ^125I organification activity of the KA groups was significantly lower than control from 30 min to 6 hr after administration. However, the ^125I organification activity at 24 hr or 48 hr after administration recovered enough to be nearly comparable with the control group. In the study in FRTL-5 cells, KA inhibited iodine organification dose-dependently, but did not inhibit iodine uptake. These results suggest that the observed lower iodine uptake activity in the single-dose administration study in rats was due to the inhibition of iodine organification caused by the oral administration of KA, consequently decreasing iodine in the entire thyroid gland. Although serum T4 showed a tendency to decrease from 2 hr to 48 hr after administration of KA, serum TSH did not show any evident change associated with KA in the single-dose administration study in rats. Based on these results, it is presumed that a massive dose or long administration period might be needed to decrease serum T4 and increase serum TSH. From these results, it is presumed that KA affected thyroidal function when given at a massive dose or in a long administration period by inhibiting iodine organification in the thyroid.
- 日本トキシコロジー学会の論文
- 2002-12-25
著者
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Kitajima Satoshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Satoh Kanako
東京都健康安全研究センター 環境保健部
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HIGA Yoshitaka
Sansho Seiyaku Co., Ltd.
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Yoshino Hiroko
名古屋市立大学 医学研究科実験病態病理学分野
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Yoshino Hiroko
Dims Institute Of Medical Science Inc.
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Shirao Kuniaki
Gastrointestinal Oncology Division National Cancer Center Hospital
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Sai Kimie
Divislon Of Toxicology National Institute Of Health Sciences
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Sai-kato Kimie
Division Of Toxicology
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Sekita Kiyoshi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Higa Yoshitaka
Sansho Seiyaku Co. Ltd.
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Sakemi Kazue
Division Of Pharmacology And Biological Safety Research Center National Institute Of Health Sciences
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KARIYA Kimio
Kobe Gakuin University, Faculty of Pharmaceutical Sciences
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Kariya K
Kobe Gakuin University Faculty Of Pharmaceutical Sciences
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Kitajima S
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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OHKUBO Atsushi
Sansho Seiyaku Co., Ltd.
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KITAJIMA Shunichi
Panapharm Laboratories Co., Ltd.
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MORIYASU Matuko
Panapharm Laboratories Co., Ltd.
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Ohkubo Atsushi
Sansho Seiyaku Co. Ltd.
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Kitajima S
Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute
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Kariya Kimio
Kobe Gakuin Univ. Fac. Of Pharmaceutical Sciences
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Kitajima Shunichi
Panapharm Laboratories Co. Ltd.
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Moriyasu Matuko
Panapharm Laboratories Co. Ltd.
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