2C-12 Toxicokinetic Study of 2-Mercapto-benzimidazole(MBI) and its Methylated Derivative (MMBI) in Rats Treated by Repeated Oral Administration.
スポンサーリンク
概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1997-10-15
著者
-
Kitajima Satoshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Ohe Yuichiro
国立医薬品食品衛生研究所
-
Ohe Yuichiro
Department Of Medical Oncology National Cancer Center Hospital
-
SAKEMI Kazue
Division of Pharmacology, National Institute of Health Sciences
-
TSUDA Mitsuhiro
Division of Pharmacology, National Institute of Health Sciences
-
Ohno Yasuo
National Institute of Health Sciences
-
Ohno Y
Division Of Pharmacology National Institute Of Health Sciences
-
Ohno Yasuo
Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences
-
Ueda Makoto
Division Of Pathology National Institute Of Health Sciences
-
Sakemi Kazue
Division Of Pharmacology National Institute Of Health Sciences
-
Tsuda Mitsuhiro
National Institute of Health Sciences
-
Tsuda Mitsuhiro
Division Of Pharmacology National Institute Of Health Sciences
-
Sakemi K
Division Of Pharmacology National Institute Of Health Sciences
-
Sakemi Kazue
Division Of Pharmacology And Biological Safety Research Center National Institute Of Health Sciences
-
Sakemi Kazue
Division Of Pharmacology National Institute Of Hygienic Sciences
-
Tsuda Mitsuhiro
Div.of Toxicology
-
Tsuda Mitsuhiro
Division Of Pharmacology And Biological Safety Research Center National Institute Of Health Sciences
-
Usami Makoto
Division Of Pharmacology Biological Safety Research Center National Institute Of Health Sciences
-
Sakemi Kazue
National Institute of Health Sciences
-
Usami Makoto
National Institute of Health Sciences
-
Ito Rieno
National Institute of Health Sciences
-
Omori Yoshihito
Division Of Pharmacology National Institute Of Hygienic Sciences
-
Ohno Yasuo
National Inst. Of Health Sci. Tokyo Jpn
-
Usami M
Division Of Pathology National Institute Of Health Sciences
-
Ohno Yasuo
Division Of Internal Medicine And Thoracic Oncology National Cancer Center Hospital
関連論文
- Genetic Variations and Haplotypes of ABCC2 Encoding MRP2 in a Japanese Population
- Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
- 日本人におけるGSTT1及びGSTM1の遺伝子多型の同定及びハプロタイプ構造の解析
- Genetic Variations of VDR/NR1I1 Encoding Vitamin D Receptor in a Japanese Population
- Genetic Variations and Frequencies of Major Haplotypes in SLCO1B1 Encoding the Transporter OATP1B1 in Japanese Subjects : SLCO1B1^*17 is More Prevalent Than ^*15
- Expression of CYP2A6 in Tumor Cells Augments Cellular Sensitivity to Tegafur
- Three novel single nucleotide polymorphisms in UGT1A10
- Sequence-based Analysis of the CYP2D6^*36-CYP2D6^*10 Tandem-type Arrangement, a Major CYP2D6^*10 Haplotype in the Japanese Population
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- "C-1 Reproductive and Developmental Toxicity Studies of Toluene. : II. Effects of inhalation exposure on fertility in rats.
- Reproductive and Developmental Toxicity Studies of Toluene.I.Teratogenicity Study of Inhalation Exposure in Pregnant Rats.
- REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF TOLUENE I. TERATOGENICITY STUDY OF INHALATION EXPOSURE IN PREGNANT RATS
- 21C-03-4 Effects of 2-Mercaptobenzimidazole (MBI) and its methyl derivatives MMBI on rat hepatic drug metabolizing enzymes.
- 21C-03-3 Effects of Diphenyl on Hepatic Peroxysomal Enzyme and Drug-Metabolizing Enzyme Activities in BDF1 Mice.
- Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
- 2C-17 Effects of Substituted Phenylurea Pesticides and Their Metabolites in Freshly Isolated and Cultured Rat Hepatocytes.
- "B-11 Effects of triazine herbicides on isolated and primary cultured hepatocytes of rat.
- EFFECT OF CARBAMATES ON RAT HEPATOCYTES IN THE PRIMARY CULTURE
- EFFECT OF CARBAMATES ON RAT FRESHLY ISOLATED HEPATOCYTES
- THE EFFECT OF DIQUAT ON THE GAP JUNCTIONAL INTERCELLULAR COMMUNICATION BETWEEN RAT HEPATOCYTES IN PRIMARY CULTURE
- EFFECT OF ORGANOPHOSPHORUS COMPOUNDS AND THEIR METABOLITES ON RAT FRESHLY ISOLATED HEPATOCYTES
- EFFECTS OF ORGANIC PHOSPHOROUS COMPOUNDS AND THEIR METABOLITES ON RAT HEPATOCYTES IN THE PRIMARY CULTURE
- A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
- Comparison of the early gene responses of Ahr-activating chemicals using the Percellome system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- The development of Chemical Toxicogenomics Database by the "Percellome" system for the mechanism-based toxicology(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Toxicity study of Garcinia cambogia extract (3) : Testicular toxicity of Hydroxycitric acid in mice(General toxicity, Proceedings of the 32nd Annual Meeting)
- Gene Expression Property of High-Density Three-Dimensional Tissue of HepG2 Cells Formed in Radial-Flow Bioreactor(BIOINFORMATICS)
- Three-Dimensional High-Density Culture of HepG2 Cells in a 5-ml Radial-Flow Bioreactor for Construction of Artificial Liver(Biochemical Engineering)
- 日本人で新たに見いだされた低活性型CYP2D6ハプロタイプ
- "POINTS TO CONSIDER" REGARDING SAFETY ASSESSMENT OF BIOTECHNOLOGY-DERIVED PHARMACEUTICALS IN NON-CLINICAL STUDIES (ENGLISH TRANSLATION)
- CYP3A4 Gene Polymorphisms Influence Testosterone 6β-hydroxylation
- P-103 Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by A 2-Week Repeated-Dose Toxicity Study in Rats : 29)Summary.(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : OVERVIEW OF THE STUDIES
- Ethnic Differences in Genetic Polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1
- Letter to the Editor
- Response to Letter to the Editor(2)
- Response to Letter to the Editor(1)
- Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
- Effects of Oseltamivir Phosphate (Tamiflu) and Its Metabolite (GS4071) on Monoamine Neurotransmission in the Rat Brain(Communications to the Editor)
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- Construction of Model Mice which Have Humanized Immune System.
- Construction of Model Mice Which Have Humanized Immune System
- Increase in in utero exposure to a migrant, 4,4'-butylidenebis(6-t-butyl-m-cresol), from nitrile-butadiene rubber gloves on brain aromatase activity in male rats
- Endocrine Disruptive Effects of Chemicals Eluted from Nitrile-Butadiene Rubber Gloves Using Reporter Gene Assay Systems(Molecular and Cell Biology)
- In Vitro Screening Assay for Detecting Aromatase Activity Using Rat Ovarian Microsomes and Estrone ELISA(Biochemistry)
- In Vitro Screening of Psychoactive Drugs by [^S]GTPγS Binding in Rat Brain Membranes(Pharmacology)
- Androgenic and Antiandrogenic Effects of Alkylphenols and Parabens Assessed Using the Reporter Gene Assay with Stably Transfected CHO-K1 Cells (AR-EcoScreen System)
- TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
- Bodyweight change during the first 5 days of chemotherapy as an indicator of cisplatin renal toxicity
- 2A-13 Reproductive and Developmental Toxicity Studies of Toluene. III. Prenatal and postnatal study by inhalation exposure in rats.
- Problems with Registration-Directed Clinical Trials for Lung Cancer in Japan
- Phase I study of cisplatin, vinorelbine, and concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancer
- Tumor response to chemotherapy : The validity and reproducibility of RECIST guidelines in NSCLC patients
- Prospective Evaluation of the Feasibility of Cisplatin-based Chemotherapy for Elderly Lung Cancer Patients with Normal Organ Functions
- A 13-WEEK TOXICITY STUDY OF SIMULTANEOUS ADMINISTRATION OF COCHINEAL AND ALUMINUM POTASSIUM SULFATE IN RATS
- 21C-01-3 Genetic polymorphisms of carcinogen-activating human phenol sulfotransferase and arylamine n-acetyltransferase, and urothelial cancer susceptibiltiy.
- ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-ISOBUTYLIDENEBIS (4,6-DIMETHYLPHENOL) IN RATS
- Analysis of the effect of dietary phytoestrogens on the gene expression profiles of endocrine disruptors using the "Percellome" system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- P7-35 Three-months dietary toxicity study of o-cymen-5-ol(biosol) in rats : Biosol induced renal injury and thymocyte apoptosis(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Toxicity study of Garcinia cambogia extract II : A28-day dietary exposure of hydroxycitric acid, a principal ingredient of Garcinia cambogia extract, on testicular toxicity in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings
- Toxicity study of Garcinia canbogia extract I : A 52-week-toxicity study of Garcinia cambogia extract in rats (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
- Effects of granulocyte-colony stimulatig factor in newborn rats.
- Sample surveillance for clinical pathology testing.
- ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS(4-METHYL-6-TERT-BUTYLPHENOL) IN RATS
- Intrauterine environment-genome interaction and Children's development (2) : Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams
- Gene expression profiling of a gene-targeted mouse embryo using the "Percellome" system as a model for molecular developmental toxicity(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- CHRONIC ORAL TOXICITY STUDY OF A SYNTHETIC ANTIOXIDANT, 2, 2'-METHYLENEBIS(4-ETHYL-6-TERT-BUTYLPHENOL)(MBEBP)IN RATS
- STUDY ON THE TOXICITY OF 2,2'-METHYLENE-bis(4-ETHYL-6-tert-BUTYLPHENOL) IN RAT (NO.1)
- Effect of Estradiol and Nonyiphenol on mRNA Expression of Estrogen Receptors α and β, and Cytochrome P450 Aromatase in the Gonad of Chicken Embryos
- Improvement in Reliability of Probabilistic Test of Significant Differences in GeneChip Experiments
- "P-35 Contribution of Oxidative Stress to Rat Hepatotoxicity induced by 2-Nitropropane : Lipid Peroxidation and Inhibitory Effect of Green Tea.
- TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS (4-ETHYL-6-TERT-BUTYLPHENOL) IN RATS 2. UNCOUPLING EFFECT ON OXIDATIVE PHOSPHORYLATION OF LIVER MITOCHONDRIA
- Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: A retrospective analysis of the data from the Japan Clinical Oncology Group trials (JCOG0003A)
- EFFECTS ON FETAL GROWTH OF REPEATED BLOOD COLLECTION FOR TOXICOKINETICS FROM PREGNANT RATS
- Genetic Polymorphisms of Copper- and Platinum Drug-efflux Transporters ATP7A and ATP7B in Japanese Cancer Patients
- EFFECTS OF KOJIC ACID ON THYROIDAL FUNCTIONS IN RATS BY SINGLE-DOSE ADMINISTRATION AND IN CULTURED RAT THYROID CELLS (FRTL-5 CELLS)
- O-2 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Cyclophosphamide in Rats.(Proceedings of the 27th Annual Meeting)
- STUDIES ON THYROID FUNCTION IN RATS SUBJECTED TO REPEATED ORAL ADMINISTRATION WITH KOJIC ACID
- 21D-03-2 Action Mechanism of Kojic Acid on Rat Thyroid Function
- Effect of Kojic Acid on Rat Thyroid Gland Administered Orally for 4 Weeks
- "B-3 Toxicokinetic Study of 2-Mercaptobenzimidazole (MBI) and its Methylated Derivative (MMBI) in Rats after Single Oral-Dose Administration.
- Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer
- LOSS OF VIABILITY AFTER DISULFIRAM TREATMENT WITHOUT PRECEDING DEPLETION OF INTRACELLULAR GSH
- ORIGIN AND CHARACTERISTICS OF FRESHLY ISOLATED RENAL CELLS OBTAINED BY PERFUSION OF COLLAGENASE IN VITRO
- MORPHINE METABOLISM IN ISOLATED HEPATOCYTES AND ITS IMPLICATIONS FOR HEPATOTOXICITY
- COMPARISONS OF THE TOXICOKINETIC PARAMETERS IN RATS DETERMINED FOR LOW AND HIGH DOSE OF γ-CHLORDANE
- FETAL TOXICITY OF ZINC ETHYLPHENYLDITHIOCARBAMATE(ZEPC)(3). MECHANISM OF FORMATION OF METHEMOGLOBIN CAUSED BY ZEPC
- COMPARATIVE STUDY ON METABOLISM OF N-NITROSODIMETHYLAMINE AND N-NITROSOMETHYLBENZYLAMINE IN RAT LIVER
- RENAL MICROSOMAL N-NITROSODIMETHYLAMINE DEMETHYLASE DETERMINED BY A SENSITIVE RADIOMETRIC METHOD
- INFLUENCE OF DOSE ON THE TOXICOKINETICS OF γ-CHLORDANE
- COMPARATIVE TOXICOKINETIC STUDY OF RUBBER ANTIOXIDANTS, 2-MERCAPTOBENZIMIDAZOLE AND 2-MERCAPTOMETHYLBENZIMIDAZOLE, BY SINGLE ORAL ADMINISTRATION IN RATS
- 22D-11-3 Increased Liver and Kidney Toxicities in Rats Caused by Co-administration of 2-Mercaptobenzimidazole (MBI) and Lipopolysaccharide (LPS) and Their Toxicokinetics (TK).
- Comparison of Thyroid Toxicity and Toxicokinetics of 2-Mercapto-4-methylbenzimidazole (4MeMBI) and its 5-Methyl Isomer (5MeMBI), Rubber antioxidant, in Rats by Single and Repeated Oral-Dose Administrations
- Endogenous Nitric Oxide Formation Stimulated by LPS in Hypothyroid Rats Induced by 2-Mercaptobenzimidazole (MBI)
- 2C-13 Toxicokinetic Study of 2-Mercapto-benzimidazole(MBI) and its Methylated Derivative (MMBI) in Rats Treated by Repeated Oral Administration - Metabolism and urinary Excretion
- 2C-12 Toxicokinetic Study of 2-Mercapto-benzimidazole(MBI) and its Methylated Derivative (MMBI) in Rats Treated by Repeated Oral Administration.
- 219 EFFECTS OF 2-MONOCHLORODIBENZOFURAN AND 3-MONOCHLORODIBENZOFURAN ON THE P450-MEDIATED DRUG METABOLIZING ENZYME ACTIVITIES OF PRIMARY CULTURED RAT HEPATOCYTES : COMPARISION WITH THE EFFECTS OF DIOXINS AND METHLCHOLANTHRENE
- Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence