Effects of Oseltamivir Phosphate (Tamiflu) and Its Metabolite (GS4071) on Monoamine Neurotransmission in the Rat Brain(Communications to the Editor)
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概要
- 論文の詳細を見る
As abnormal behaviors such as jumping and falling from balcony were reported in patients aged 10 to 19 years who administrated oseltamivir phosphate (Tamiflu) for treatment influenza infection, the Ministry of Health, Labor and Welfare in Japan notified that, as a rule, Tamiflu should not be prescribed to patients aged 10 to 19 years. To examine the relationship between Tamiflu and abnormal behaviors, we investigated the effects of Tamiflu and its carboxylic acid metabolite, GS4071, on the central nervous system, that is, on 3 neurotransmitters (dopamine, serotonin, and norepinephrine) in presynapses (inhibition of reuptake, promotion of release) and postsynapses (guanosine 5'-triphosphate (GTP) γS binding), using rat brain synaptosomes. Neither Tamiflu nor GS4071 influenced the re-uptake/release of the 3 monoamines or GTP binding in postsynapses.
- 社団法人日本薬学会の論文
- 2007-09-01
著者
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NAKAE Dai
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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SATOH Kanako
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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OGATA Akio
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Ogata Akio
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Ogata Akio
東京都健康安全研究センター
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Ogata Akio
東京都健康安全研究センター 環境保健部
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Kitajima Satoshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Satoh Kanako
東京都健康安全研究センター 環境保健部
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Satoh Kanako
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Nakae Dai
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Shirao Kuniaki
Gastrointestinal Oncology Division National Cancer Center Hospital
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Sai Kimie
Divislon Of Toxicology National Institute Of Health Sciences
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Sai-kato Kimie
Division Of Toxicology
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Sekita Kiyoshi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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Nakae Dai
東京都健康安全研究センター 環境保健部
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NONAKA Ryouichi
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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UEHARA Shin-ichi
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Sakemi Kazue
Division Of Pharmacology And Biological Safety Research Center National Institute Of Health Sciences
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Uehara Shin-ichi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Kitajima S
Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute
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Nonaka Rhouichi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Nonaka Ryouichi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Nakae Dai
Department Of Pharmaceutical Sciences Tokyo Metropolitan Institute Of Public Health
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