Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats
スポンサーリンク
概要
- 論文の詳細を見る
The present study assessed a carcinogenic hazard of multi-wall carbon nanotube (MWCNT) in intact (not genetically modified) rodents. MWCNT (1mg/kg body weight, 7 animals), crocidolite (2mg/kg body weight, 10 animals) or vehicle (2% carboxymethyl cellulose, 5 animals) was administered to male Fischer 344 rats (12 weeks old) by a single intrascrotal injection. Rats were autopsied immediately after death, when becoming moribund or at the end of the maximal observation period scheduled to be 52 weeks. After 37-40 weeks, however, 6 MWCNT treated animals died or became moribund due to intraperitoneally disseminated mesothelioma (6/7, 85.7%) with bloody ascites. Peritoneal mesothelium was generally hypertrophic, and numerous nodular or papillary lesions of mesothelioma and mesothelial hyperplasia were developed. While mesothelioid cells were predominant in relatively early stage tumors, advanced stage mesotheliomas were constituted by 2 portions occupied by mesothelioid cells on the surface and spindle-shaped sarcomatous cells in the depth. In the latter, the histological transition was apparently observed between these 2 portions. Mesotheliomas were invasive to adjacent organs and tissues, and frequently metastasized into the pleura. Only 1 rat survived for 52 weeks in the MWCNT-treated group, and similar findings except mesothelioma were observed. All 10 crocidolite-treated and 5 vehicle-treated rats survived for 52 weeks without any particular changes except deposition of asbestos in the former case. It is thus indicated that MWCNT possesses carcinogenicity causing mesothelioma at a high rate in intact male rats under the present experimental conditions. The present data identifies a carcinogenic hazard of MWCNT and will serve as one of the indispensable evidences to be used for the risk assessment crucial for not only protection and improvement of human health and welfare, but also safe and acceptable development and prevalence of this and similar upcoming materials.
- 日本トキシコロジー学会の論文
- 2009-02-01
著者
-
Hirose Akihiko
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science
-
SAKAMOTO Yoshimitsu
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
-
NAKAE Dai
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
-
OHASHI Norio
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
-
OGATA Akio
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
-
Ogata Akio
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Ogata Akio
東京都健康安全研究センター
-
Ogata Akio
東京都健康安全研究センター 環境保健部
-
Hirose Akihiko
National Inst. Of Health Sciences
-
Nishimura Tetsuji
Environmental Chemistry National Institute Of Health Sciences
-
Ohashi Norio
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Ohashi Norio
東京都健康安全研究センター
-
Sakamoto Yoshimitou
東京都公害研
-
Sakamoto Yoshimitsu
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Nakae Dai
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
NISHIMURA Tetsuji
Division of Environmental Health, National Institute of Health Sciences
-
Hirose Akihiko
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
-
Nakae Dai
東京都健康安全研究センター 環境保健部
-
Hirose Akihiko
Division Of Risk Assessment National Institute Of Health Sciences
-
Nishimura Tetsuji
Division Of Environmental Chemistry
-
Fukumori Nobutaka
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
-
Tayama Kuniaki
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
-
Maekawa Akihiko
Tokyo University of Agriculture
-
Imai Kiyoshi
Biosafety Research Center Foods, Drugs and Pesticides
-
Hirose Akihiko
Division Of Toxicology National Institute Of Health Sciences
-
Imai Kiyoshi
Biosafety Research Center Foods Drugs And Pesticides
-
Tayama Kuniaki
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Ohashi Norio
Department Of Dermatology Saitama Medical Center Saitama Medical School
-
Hirose Akihiko
National Inst. Of Health Sciences (nihs)
-
Maekawa Akihiko
Tokyo University Of Agriculture:safety Assessment Division Chemical Management Center National Insti
-
Fukumori Nobutaka
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Ando Hiroshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Hirose Akihiko
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
-
Nakae Dai
Department Of Pharmaceutical Sciences Tokyo Metropolitan Institute Of Public Health
関連論文
- Effects of preparation methods for multi-wall carbon nanotube (MWCNT) suspensions on MWCNT induced rat pulmonary toxicity
- Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
- Relation between statistics and treatment-related changes obtained from toxicity studies in rats : if detected a significant difference in low or middle dose for quantitative values, this change is considered as incidental change?
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
- Evaluation of developmental toxicity of UV stabilizer 2-(3', 5'-di-tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole in rats(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Effects of progesterone on implantation failure induced by dibutyltin dichloride in rats (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 3A-11 Effects of a peroxisome proliferator on DNA damage inducible-gene products induced by methyl methane sulfonate (MMS) in the primary hepatocytes culture of the rat
- 3A-08 A Chronic Inhalation Study of p-Dichlorobenzene in the F344 Rat
- "C-1 Reproductive and Developmental Toxicity Studies of Toluene. : II. Effects of inhalation exposure on fertility in rats.
- Reproductive and Developmental Toxicity Studies of Toluene.I.Teratogenicity Study of Inhalation Exposure in Pregnant Rats.
- REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF TOLUENE I. TERATOGENICITY STUDY OF INHALATION EXPOSURE IN PREGNANT RATS
- THE TOXICITY STUDY OF BIODEGRADABLE PLASTIC IN RATS BY DIETARY ADMINISTRATION
- TWENTY-EIGHT-DAY REPEATED DOSE TOXICITY TESTS OF O-NITROTOLUENE IN WISTAR RATS
- ACUTE INHALATION TOXICITY TESTS OF DICHLOROSILANE AND TETRAFLUOROSILANE(THE SPECIALTY GASES)
- 306 A 28-DAY REPEATED DOSE TOXICITY TEST OF EUROPIUM AND GADORINIUM IN WISTAR RAT IN COMPARISON WITH LANTHANUM AND YTTRIUM
- 407 A 28-DAY REPEATED DOSE TOXICITY TEST OF LANTHANUM AND YTTRIUM IN WISTAR RAT
- 206 A 28-DAY REPEATED INHALATION TOXICITY TEST OF 2,2,3,3,3-PENTAFLUOROPROPANOL IN F344 RAT
- Effects of preparation methods for multi-wall carbon nanotube (MWCNT) suspensions on MWCNT induced rat pulmonary toxicity
- α-Naphthylisothiocyanate Induces Intrahepatic Bile Duct with Greater Proliferation in Female Rats than in Males
- Study of 1, 4-Dioxane Intake in the Total Diet
- Study of 1,4-Dioxane Intake in the Total Diet Using the Market-Basket Method
- Peroxisome Proliferators Attenuate Free Arachidonic Acid Pool in the Kidney Through Inducing Lysophospholipid Acyltransferases
- Possible Involvement of Adaptation Mechanisms in the Achievement of an Ineffective Dose Range for the Carcinogenicity of Genotoxic Carcinogens
- Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) in rats
- Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet
- Development of Hepatocellular Adenomas and Carcinomas Associated with Fibrosis in C57BL/6J Male Mice Given a Choline-deficient, L-Amino Acid-defined Diet
- Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
- Inhibition of Early-phase Exogenous and Endogenous Liver Carcinogenesis in Transgenic Rats Harboring a Rat Glutathione S-Transferase Placental Form Gene
- Systemic mast cell disease with splenic infarction : A case report
- Promotion of Rat Hepatocarcinogenesis by Dimethylarsinic Acid : Association with Elevated Ornithine Decarboxylase Activity and Formation of 8-Hydroxydeoxyguanosine in the Liver
- Inhibition by Green Tea Extract of Diethylnitrosamine-initiated but Not Choline-deficient, L-Amino Acid-defined Diet-associated Development of Putative Preneo-plastic, Glutathione S-Transferase Placental Form-positive Lesions in Rat Liver
- Increased Telomerase Activity in Hyperplastic Nodules and Hepatocellular Carcinomas Induced by a Choline-deficient L-Amino Acid-defined Diet in Rats
- Dose-dependent Induction of 8-Hydroxyguanine and Preneoplastic Foci in Rat Liver by a Food-derived Carcinogen, 2-Amino-3, 8-dimethylimidazo [4,5-f] quinoxaline, at Low Dose Levels
- Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline-deficient L-Amino Acid-defined Diet and Ethionine in Rats
- Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice
- Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma
- Exercise Training Enhances Tumor Necrosis Factor-α-Induced Expressions of Anti-Apoptotic Genes without Alterations in Caspase-3 Activity in Rat Epididymal Adipocytes
- α-Smooth Muscle Actin-positive Stromal Cells Reactive to Estrogens Surround Endometrial Glands in Rats but not Mice
- O-11 Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 3
- Effects of Maternal Exposure to Nonylphenol on Growth and Development of the Female Reproductive System and Uterine Carcinogenesis in Rats
- Effect of neonatal exposure of high dose p-tert octylphenol on the ovary in rats (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Carcinogenic risks in the high-risk groups (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats
- A case of early gastric malignanat lymphoma diagnosed and completely resected by strip biopsy
- REVISION AND ESTABLISHMENT OF JAPANESE DRINKING WATER QUALITY GUIDELINES FOR DI(2-ETHYLHEXYL) PHTHALATE, TOLUENE AND VINYL CHLORIDE : DIFFERENCES FROM THE LATEST WHO GUIDELINE DRAFTS
- A Review of Nomenclature and Diagnostic Criteria for Proliferative Lesions in the Liver of Rats by a Working Group of the Japanese Society of Toxicologic Pathology
- Letter to the Editor
- Response to Letter to the Editor(2)
- Response to Letter to the Editor(1)
- Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
- Effects of Oseltamivir Phosphate (Tamiflu) and Its Metabolite (GS4071) on Monoamine Neurotransmission in the Rat Brain(Communications to the Editor)
- Increase in in utero exposure to a migrant, 4,4'-butylidenebis(6-t-butyl-m-cresol), from nitrile-butadiene rubber gloves on brain aromatase activity in male rats
- Endocrine Disruptive Effects of Chemicals Eluted from Nitrile-Butadiene Rubber Gloves Using Reporter Gene Assay Systems(Molecular and Cell Biology)
- In Vitro Screening Assay for Detecting Aromatase Activity Using Rat Ovarian Microsomes and Estrone ELISA(Biochemistry)
- In Vitro Screening of Psychoactive Drugs by [^S]GTPγS Binding in Rat Brain Membranes(Pharmacology)
- Decreased Expression of Bcl-x Protein during Hepatocarcinogenesis Induced Exogenously and Endogenously in Rats
- 2A-13 Reproductive and Developmental Toxicity Studies of Toluene. III. Prenatal and postnatal study by inhalation exposure in rats.
- LIMB DEFORMITY INDUCED IN CHICK EMBRYO BY HYDROXYUREA
- The Effects of in Utero Exposure to a Migrant, 4,4'-Butylidenebis(6-t-butyl-m-cresol), from Nitrile-Butadiene Rubber Gloves on Monoamine Neurotransmitter in Rats(Biochemistry)
- Letter to the Editor(1)
- Characteristic expression of connective tissue components and matrix metalloproteinases (MMPs) during the development of pressure ulcerations
- Metabolism of 2,2,3,3,3-Pentafluoropropanol (5-FP) in Rats (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Demonstration of Antigenic and Genotypic Variation in Orientia tsutsugamushi Which Were Isolated in Japan, and Their Classification into Type and Subtype
- ANALYSIS OF CONSTITUTIONAL PROTEINS AND ANTIGENIC COMPONENTS IN RICKETTSIA TSUTSUGAMUSHI
- SEMI-QUANTITATIVE IMMUNOHISTOCHEMICAL ANALYSIS OF MALE RAT-SPECIFIC α_2u-GLOBULIN ACCUMULATION FOR CHEMICAL TOXICITY EVALUATION
- Risk assessment for the endocrine distruption effects by bisphenol A (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P10-17 Risk assessment for formaldehyde in drinking water via oral and inhalation exposure.
- P-75 Toxicity evaluation of a strong mutagen MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) in drinking water.(Proceedings of the 27th Annual Meeting)
- Endogenous liver carcinogenesis in the rat
- Subcellular Distribution of Rat Liver NADPH-2,4-Dienoyl-CoA Reductase
- Paraneoplastic Pemphigus : Report of a Case
- Oscillation theory for a class of second order quasilinear ordinary differential equations with application to partial differential equations
- On Certain Representations for the Solution of the Vector Helmholtz Equation
- Principles of risk assessment for determining the safety of chemicals : Recent assessment of residual solvents in drugs and di(2-ethylhexyl) phthalate
- Disappearance of gender-related difference in the toxicity of benzotriazole ultraviolet absorber in juvenile rats
- Placental-transfer of tetrabromobisphenol A in mice(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- On Bounded Solutions for Elliptic Equations with Coefficients Singular at the Boundary in an Unbounded Domain
- Influence of coefficient of variation in determining significant difference of quantitative values obtained from 28-day repeated-dose toxicity studies in rats
- Fullerene (C_) Is Negative in the In Vivo Pig-A Gene Mutation Assay
- Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats
- Toxicological bases for micro-dose study(Toxicological Bases for Micro-dose Study, Proceedings of the 32nd Annual Meeting)
- Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats : Evidence for the existence of no-effect levels and a mechanism involving p21^
- Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats
- Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice
- Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice
- Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
- Determination of dose dependence in repeated dose toxicity studies when mid-dose alone is insignificant
- Repeated dose and reproductive/developmental toxicity of perfluorooctadecanoic acid in rats
- No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats
- Sub-acute oral toxicity study with fullerene C60 in rats
- Carcinogen-induced Thyroid Proliferative Lesions in Wistar Hannover GALAS Rats with Thyroid Dysplasia
- A 90-day Feeding Toxicity Study of L-Serine in Male and Female Fischer 344 Rats
- Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
- Response to Letter to the Editor(2)
- Acute Phase Pulmonary Responses to a Single Intratracheal Spray Instillation of Magnetite (Fe3O4) Nanoparticles in Fischer 344 Rats
- Long-term Pulmonary Responses to Quadweekly Intermittent Intratracheal Spray Instillations of Magnetite (Fe3O4) Nanoparticles for 52 Weeks in Fischer 344 Rats
- Increase in in Utero Exposure to a Migrant, 4,4'-Butylidenebis(6-t-butyl-m-cresol), from Nitrile-Butadiene Rubber Gloves on Brain Aromatase Activity in Male Rats
- P-061(O-9) Using Existing In Vitro Structural Alters For Chromosome Damage To Predict In Vivo Activity And Direct Future Testing(Poster presentation)
- Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat