Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice
スポンサーリンク
概要
- 論文の詳細を見る
The present study was conducted to assess involvement of oxidative stress in lung adeno-carcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene encoding an enzyme that repairs an oxidative DNA injury 8-oxoguanine (8-oxoG). Furthermore, for comparison with the human case, mutations of mouse epidermal growth factor receptor (Egfr) and K-ras genes were examined. The homo- and heterozygously Ogg1 gene-deficient and wild-type mice (C57BL6/J origin), 6 weeks old, were administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by continuous subcutaneous infusion using an osmotic pump at a total dose of 6 mg/mouse for 1 week, then treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20ppm in diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks. Development of lung adenomas and preneoplastic atypical hypreplasias was significantly enhanced by the homo- and heterozygous Ogg1 gene deficiency only in female mice with intralesion accumulation of 8-oxoG. All antioxidants tended to inhibit enhanced adeno-carcinogenesis. The Egfr and K-ras gene mutations were detected at sites also found in human lung cancers with low incidences, while the Egfr gene mutation was detected for the first time in chemical lung carcinogenesis of animals. It is indicated that the Ogg1 gene deficiency enhances lung adeno-carcinogenesis in mice by virtue of accelerated oxidative stress. The presently utilized Ogg1 gene-deficient mice model may be useful to draw mechanism-based strategies to control human lung adenocarcinomas, especially in women.
- 日本トキシコロジー学会の論文
- 2009-04-01
著者
-
NAKAE Dai
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
-
Nakae Dai
東京都健康安全研究センター
-
Nakae Dai
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health:toky
-
Nakae Dai
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
YOSHIDA Midori
Division of Pathology, National Institute of Health Sciences
-
Yoshida Midori
National Institute of Health Sciences
-
Sugano Sumio
Laboratory Of Functional Genomics Department Of Medical Genome Sciences Graduate School Of Frontier
-
Yoshida Midori
Div. Of Pathology National Inst. Of Health Sciences
-
Yoshida Midori
Division Of Pathology National Institute Of Health Sciences
-
Igarashi Maki
Laboratory of Protection of Body Function, Department of Food and Nutritional Science, Graduate Scho
-
Watanabe Manabu
Laboratory of Functional Genomics, Department of Medical Genome Sciences, Graduate School of Frontie
-
Sugaya Kouichi
Laboratory of Protection of Body Function, Department of Food and Nutritional Science, Graduate Scho
-
Endo Yoshifumi
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, University of T
-
Miyajima Nozomi
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, University of T
-
Abe Masayoshi
Toxicology and Environmental Science Department, Biological Research Laboratories, Nissan Chemical I
-
Igarashi Maki
Laboratory Of Protection Of Body Function Department Of Food And Nutritional Science Graduate School
-
Abe Masayoshi
Department Of Pathology Sasaki Institute
-
Abe Masayoshi
Biological Research Laboratories, Nissan Chemical Industries, Ltd.
-
Abe Masayoshi
Biological Research Laboratories Nissan Chemical Industries Ltd.
-
Sugaya Kouichi
Laboratory Of Protection Of Body Function Department Of Food And Nutritional Science Graduate School
-
Endo Yoshifumi
Laboratory Of Veterinary Surgery Graduate School Of Agricultural And Life Sciences University Of Tok
-
Miyajima Nozomi
Laboratory Of Veterinary Surgery Graduate School Of Agricultural And Life Sciences University Of Tok
-
Nakae Dai
Department Of Pathology Sasaki Institute
-
Watanabe Manabu
Laboratory Of Functional Genomics Department Of Medical Genome Sciences Graduate School Of Frontier
-
ENDO Yoshifumi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069–8501, Japan
-
ENDO Yoshifumi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University
関連論文
- Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals
- Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction
- Collaborative work on evaluation of ovarian toxicity by repeated-dose and fertility studies in female rats
- Ultrasonic-induced tonic convulsion in rats after subchronic exposure to perfluorooctane sulfonate (PFOS)
- α-Naphthylisothiocyanate Induces Intrahepatic Bile Duct with Greater Proliferation in Female Rats than in Males
- Possible Involvement of Adaptation Mechanisms in the Achievement of an Ineffective Dose Range for the Carcinogenicity of Genotoxic Carcinogens
- Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) in rats
- Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet
- Development of Hepatocellular Adenomas and Carcinomas Associated with Fibrosis in C57BL/6J Male Mice Given a Choline-deficient, L-Amino Acid-defined Diet
- Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
- Inhibition of Early-phase Exogenous and Endogenous Liver Carcinogenesis in Transgenic Rats Harboring a Rat Glutathione S-Transferase Placental Form Gene
- Systemic mast cell disease with splenic infarction : A case report
- Promotion of Rat Hepatocarcinogenesis by Dimethylarsinic Acid : Association with Elevated Ornithine Decarboxylase Activity and Formation of 8-Hydroxydeoxyguanosine in the Liver
- Inhibition by Green Tea Extract of Diethylnitrosamine-initiated but Not Choline-deficient, L-Amino Acid-defined Diet-associated Development of Putative Preneo-plastic, Glutathione S-Transferase Placental Form-positive Lesions in Rat Liver
- Increased Telomerase Activity in Hyperplastic Nodules and Hepatocellular Carcinomas Induced by a Choline-deficient L-Amino Acid-defined Diet in Rats
- Dose-dependent Induction of 8-Hydroxyguanine and Preneoplastic Foci in Rat Liver by a Food-derived Carcinogen, 2-Amino-3, 8-dimethylimidazo [4,5-f] quinoxaline, at Low Dose Levels
- Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline-deficient L-Amino Acid-defined Diet and Ethionine in Rats
- Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection
- Points to consider on the non-clinical safety evaluation of anticancer drugs
- Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice
- Preliminary Evaluation of Toxicologic and Carcinogenic Risks of Copper Gluconate in Rats Given Multiple Carcinogens
- Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma
- Expression of profiles of cytochrome P450 enzymes in the uterus and liver of female rats treated with indole-3-carbinol(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- Exercise Training Enhances Tumor Necrosis Factor-α-Induced Expressions of Anti-Apoptotic Genes without Alterations in Caspase-3 Activity in Rat Epididymal Adipocytes
- α-Smooth Muscle Actin-positive Stromal Cells Reactive to Estrogens Surround Endometrial Glands in Rats but not Mice
- O-11 Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 3
- Effects of Maternal Exposure to Nonylphenol on Growth and Development of the Female Reproductive System and Uterine Carcinogenesis in Rats
- Effect of neonatal exposure of high dose p-tert octylphenol on the ovary in rats (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Carcinogenic risks in the high-risk groups (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- Molecular analysis of rat mammary carcinogenesis : an approach from carcinogenesis research to cancer prevention
- Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats
- A case of early gastric malignanat lymphoma diagnosed and completely resected by strip biopsy
- EI-2346, a Novel Interleukin-1 βConverting Enzyme Inhibitor Produced by Streptomyces sp. E-2346 : II. Structure Elucidation
- EI-2346, a Novel Interleukin-1 β Converting Enzyme Inhibitor Produced by Streptomyces sp. E-2346 : I. Taxonomy of Producing strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties
- EI-1941-1 and -2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941 : II. Taxonomy of Producing Strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties
- RP-1551s, a Family of Azaphilones Produced by Penicillium sp., Inhibit the Binding of PDGF to the Extracellular Domain of Its Receptor
- Effects of Storage Temperature on the Contents of Sugars and Free Amino Acids in Tubers from Different Potato Cultivars and Acrylamide in Chips
- Change in Content of Sugars and Free Amino Acids in Potato Tubers under Short-Term Storage at Low Temperature and the Effect on Acrylamide Level after Frying
- A Review of Nomenclature and Diagnostic Criteria for Proliferative Lesions in the Liver of Rats by a Working Group of the Japanese Society of Toxicologic Pathology
- Long-Term Treatment with Bromocriptine Inhibits Endometrial Adenocarcinoma Development in Rats
- Erratum : Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals
- Effects of Oseltamivir Phosphate (Tamiflu) and Its Metabolite (GS4071) on Monoamine Neurotransmission in the Rat Brain(Communications to the Editor)
- Increase in in utero exposure to a migrant, 4,4'-butylidenebis(6-t-butyl-m-cresol), from nitrile-butadiene rubber gloves on brain aromatase activity in male rats
- Quantification of Light-Induced Glycoalkaloids, α-Solanine and α-Chaconine, in Four Potato Cultivars (Solanum tuberosum L.) Distributed in Japan by LC/MS
- Air purifiers that diffuse reactive oxygen species potentially cause DNA damage in the lung
- Decreased Expression of Bcl-x Protein during Hepatocarcinogenesis Induced Exogenously and Endogenously in Rats
- Neonatal death of mice treated with perfluorooctane sulfonate
- Accumulation of Hydroxycinnamic Acid Amides in Winter Wheat under Snow(Organic Chemistry)
- Accumulation of 3-O-feruloylquinic Acid Induced by Low Temperature in Wheat(平成17年度 第51回低温低物工学会研究報告)
- Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure
- Multi-endpoint genotoxic assay using L5178Y (Tk^ -3.7.2c) cells
- The use of an automated hematology analyzer to observe cell growth in the chromosome aberration test using human lymphocytes
- Endogenous liver carcinogenesis in the rat
- Sebaceous Gland Metaplasia in a Mammary Fibroadenoma Developing in a Female Donryu Rat
- Uterine Adenocarcinoma in N-Ethyl-N'-nitro-N-nitrosoguanidine-treated Rats with High-dose Exposure to p-tert-Octylphenol during Adulthood
- O12-16 Effects of in utero and lactational exposure to low-doses of bisphenol A on the reproductive system in female rats
- 21WA-04-1 Effects on reproductive tract of male Donryu rats by neonatal exposure of p-tert octylphenol
- 21WA-03-5 Persistent effects on the reproductive tract in female rats by neonatal exposure of p-tert-octylphenol.
- High Yield Selective Induction of Uterine Endometrial Adenocarcinomas in CD-1 Mice by N-Ethyl-N'-nitro-N-nitrosoguanidine Combined with 17β-Estradiol
- Establishment of Two-stage Rat Uterine Carcinogenicity Model
- Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat
- EI-2128-1, a Novel Interleukin-1βConverting Enzyme Inhibitor Produced by Penicillium sp. E-2128
- EI-1941-1 and -2, Novel Interleukin-1 β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941 I. Biochemical Characterization of EI-1941-1 and -2
- RP-1776, a Novel Cyclic Peptide Produced by Streptomyces sp., Inhibits the Binding of PDGF to the Extracellular Domain of Its Receptor
- Tumor Cell Growth Inhibition and Cell Differentiation Analysis in a Canine Mammary Tumor Cell Line (MCM-B2) Treated with Four Chemical Reagents
- Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay
- Reduction of Primordial Follicles Caused by Maternal Treatment with Busulfan Promotes Endometrial Adenocarcinoma Development in Donryu Rats
- Maternal Exposure to Low Doses of Bisphenol A Has No Effects on Development of Female Reproductive Tract and Uterine Carcinogenesis in Donryu Rats
- Air purifiers that diffuse reactive oxygen species potentially cause DNA damage in the lung
- Histopathological Effect of Ketoconazole on Rat Placenta(Pathology)
- Histological expression of metallothionein in the developing rat placenta
- Study on the in vivo Comet Assay Using Rat Uteri
- Ultrasonic-induced tonic convulsion in rats after subchronic exposure to perfluorooctane sulfonate (PFOS)
- Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats
- Oxidation of Bisphenol A and Related Compounds
- Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
- Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
- Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats
- Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats : Evidence for the existence of no-effect levels and a mechanism involving p21^
- Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
- Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
- Adhesional Function of Canine Mammary Gland Tumor Cells Expressing Sialyl Lewis X
- Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats
- Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice
- Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
- Delayed effects of single neonatal subcutaneous exposure of low-dose 17α-ethynylestradiol on reproductive function in female rats
- Carcinogen-induced Thyroid Proliferative Lesions in Wistar Hannover GALAS Rats with Thyroid Dysplasia
- Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
- Rhabdomyosarcoma in the Abdominal Cavity of a 12-Month-Old Female Donryu Rat
- Involvements of Estrogen Receptor, Proliferating Cell Nuclear Antigen and p53 in Endometrial Adenocarcinoma Development in Donryu Rats
- Acute Phase Pulmonary Responses to a Single Intratracheal Spray Instillation of Magnetite (Fe3O4) Nanoparticles in Fischer 344 Rats
- Long-term Pulmonary Responses to Quadweekly Intermittent Intratracheal Spray Instillations of Magnetite (Fe3O4) Nanoparticles for 52 Weeks in Fischer 344 Rats
- The Kidneys of Infant Mice are not Sensitive to the Food Mycotoxin Contaminant Nivalenol
- Increase in in Utero Exposure to a Migrant, 4,4'-Butylidenebis(6-t-butyl-m-cresol), from Nitrile-Butadiene Rubber Gloves on Brain Aromatase Activity in Male Rats
- Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat
- Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver
- Neonatal Exposure to 17α-Ethinyl Estradiol Affects Kisspeptin Expression and LH-Surge Level in Female Rats
- A 13-week subchronic toxicity study of grape skin extract in F344 rats