Adhesional Function of Canine Mammary Gland Tumor Cells Expressing Sialyl Lewis X
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概要
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The adhesional function to blood vessel endothelial cells was evaluated in 2 cultured canine mammary gland tumor cells, CHMp and CHMm, derived from the primary and the metastatic lesion of the same patient. They exhibited negative (CHMp) and positive (CHMm) expression of sialyl Lewis X [sLe(x)], respectively. In the cell adhesion assay, the number of attached CHMm cells to human umbilical vein endothelial cells which expressed activated E-selectin was significantly increased. The process of cell-cell adhesion under flow conditions was observed only in CHMm cells. CHMm cells were revealed to have the adhesional ability to blood vessel endothelial cells and this adhesional ability was thought to be induced by the sLe(x)-E-selectin binding.
著者
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Sugano Sumio
Laboratory Of Functional Genomics Department Of Medical Genome Sciences Graduate School Of Frontier
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MOCHIZUKI Manabu
Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, Tokyo University of
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Nakagawa Takayuki
Laboratory Of Developmental Immunology And Crest Program Of Japan Science And Technology Agency Grad
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Watanabe Manabu
Laboratory Of Functional Genomics Department Of Medical Genome Sciences Graduate School Of Frontier
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ENDO Yoshifumi
Laboratory of Veterinary Clinical Oncology, Small Animal Clinical Sciences, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069–8501, Japan
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SUGANO Sumio
Laboratory of Functional Genomics, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo
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NISHIMURA Ryohei
Laboratory of Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SASAKI Nobuo
Laboratories of Veterinary Surgery, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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