Trehalose May Prevent Postsurgical Adhesions in a Rabbit Model of Hysterotomy
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概要
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The adhesion-preventing effect of trehalose in visceral organs was evaluated in a rabbit model. All rabbits underwent a hysterotomy, during which mild abrasion and desiccation was induced on the surfaces of visceral organs. In the control group, the intestines were kept dry during hysterotomy. In the saline and trehalose groups, saline solution and 7% trehalose solution, respectively, were sprayed on the organ surfaces. Adhesion formation on organ surfaces on which abrasion and desiccation were induced declined significantly in the trehalose group compared with the other groups. In contrast, at the hysterotomy site, there was no significant difference in adhesions between groups, suggesting that trehalose prevents adhesions in organs that have developed minor inflammation by abrasion and desiccation.
著者
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NISHIMURA Ryohei
Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The
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SASAKI Nobuo
Laboratory of Veterinary Surgery, Faculty of Agriculture, University of Tokyo
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MOCHIZUKI Manabu
Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, Tokyo University of
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FUJINO Hiroko
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University
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LEE Soojung
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University
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SUZUKI Shigeki
NEXT21
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CHUNG Ung-Il
Department of Bioengineering, School of Engineering, The University of Tokyo
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CHUNG Ung-Il
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
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SASAKI Nobuo
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SASAKI Nobuo
Laboratory of Surgery, Veterinary Medical Science, The University of Tokyo
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FUJINO Hiroko
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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NISHIMURA Ryohei
Laboratory of Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SASAKI Nobuo
Laboratories of Veterinary Surgery, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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