Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model
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概要
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We investigated biodegradability and new bone formation after implantation of tetrapod-shaped granular artificial bone (Tetrabone®) or β-tricalcium phosphate granules (β-TCP) in experimental critical-size defects in dogs, which were created through medial and lateral femoral condyles. The defect was packed with Tetrabone® (Tetrabone group) or β-TCP (β-TCP group) or received no implant (control group). Computed tomography (CT) was performed at 0, 4 and 8 weeks after implantation. Micro-CT and histological analysis were conducted to measure the non-osseous tissue rate and the area and distribution of new bone tissue in the defect at 8 weeks after implantation. On CT, β-TCP was gradually resorbed, while Tetrabone® showed minimal resorption at 8 weeks after implantation. On micro-CT, non-osseous tissue rate of the control group was significantly higher compared with the β-TCP and Tetrabone groups (P<0.01), and that of the β-TCP group was significantly higher compared with the Tetrabone group (P<0.05). On histology, area of new bone tissue of the β-TCP group was significantly greater than those of the Tetrabone and control groups (P<0.05), and new bone distribution of the Tetrabone group was significantly greater than those of the β-TCP and control groups (P<0.05). These results indicate differences in biodegradability and connectivity of intergranule pore structure between study samples. In conclusion, Tetrabone® may be superior for the repair of large bone defects in dogs.
- 公益社団法人 日本獣医学会の論文
著者
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Chung Ung-il
Center For Disease Biology And Integrated Medicine School Of Medicine University Of Tokyo:department
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MOCHIZUKI Manabu
Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, Tokyo University of
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SUZUKI Shigeki
NEXT21
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Ohba Shinsuke
Center For Disease Biology And Integrated Medicine School Of Medicine University Of Tokyo
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Sakai Takamasa
Department Of Electrical Engineering The Faculty Of Engineering Hokkaido University:clarion Corp.
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Nishimura Ryouhei
Laboratory Of Veterinary Emergency Medicine Graduate School Of Agricultural And Life Sciences The Un
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MOCHIZUKI Manabu
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SASAKI Nobuo
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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SASAKI Nobuo
Laboratory of Surgery, Veterinary Medical Science, The University of Tokyo
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CHUNG Ung-Il
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
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CHOI Sungjin
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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LIU I-Li
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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YAMAMOTO Kenichi
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
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HONNAMI Muneki
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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ECHIGO Ryosuke
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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OHBA Shinsuke
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
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SAKAI Takamasa
Department of Bioengineering, School of Engineering, The University of Tokyo
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