S100A1 and S100B are dispensable for endochondral ossification during skeletal development
スポンサーリンク
概要
- 論文の詳細を見る
S100A1 and S100B are induced by the SOX trio transcription factors (SOX9, SOX5, and SOX6) in chondrocytes, and inhibit their hypertrophic differentiation in culture. However, functional roles of S100A1 and S100B during in vivo skeletal development are yet to be determined. Here we show that mice deficient of both the S100a1 and S100b genes displayed normal skeletal growth from embryonic stage to adulthood. Although no compensatory upregulation of other S100 family members was observed in S100a1/S100b double mutants, the related S100a2, S100a4, S100a10, and S100a11 were expressed at similarly high levels to S100a1 and S100b in mouse primary chondrocytes. Furthermore, overexpression of these other S100 members suppressed the hypertrophic differentiation of chondrocytes in vitro as efficiently as S100A1 and S100B. Taken together, the present study demonstrates that S100A1 and S100B are dispensable for endochondral ossification during skeletal development, most likely because their deficiency may be masked by other S100 proteins which have similar functions to those of S100A1 and S100B.
- バイオメディカルリサーチプレスの論文
著者
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Chung Ung-il
Center For Disease Biology And Integrated Medicine School Of Medicine University Of Tokyo:department
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Kawaguchi Hiroshi
Sensory And Motor System Medicine Faculty Of Medicine University Of Tokyo
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CHUNG Ung-il
Center for Disease Biology and Integrative Medicine,Faculty of Medicine, University of Tokyo
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MORI Yoshifumi
Sensory & Motor System Medicine, Faculty of Medicine, University of Tokyo
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MORI Daisuke
Bone and Cartilage Regenerative Medicine, Faculty of Medicine, University of Tokyo
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TANAKA Sakae
Sensory & Motor System Medicine, Faculty of Medicine, University of Tokyo
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HEIERHORST Jörg
St. Vincent's Institute of MedicalResearch, and Department of Medicine, St. Vincent's Hospital, The University of Melbourne
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BUCHOU Thierry
Inserm, U823, Université Joseph Fourier-Grenoble 1, Institut Albert Bonniot, faculté de Médecine, La tronche, France
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BAUDIER Jacques
Inserm, U823, Université Joseph Fourier-Grenoble 1, Institut Albert Bonniot, faculté de Médecine, La tronche, France
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SAITO Taku
Sensory & Motor System Medicine, Faculty of Medicine, University of Tokyo
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- S100A1 and S100B are dispensable for endochondral ossification during skeletal development