Lyophilized Aspirin with Trehalose May Decrease the Incidence of Gastric Injuries in Healthy Dogs

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概要

• 論文の詳細を見る

• Trehalose has several novel anti-inflammatory and cell-protective functions. We hypothesized that lyophilized aspirin/trehalose could decrease the severity of aspirin-induced gastropathy. Thirteen dogs were assigned into aspirin, lyophilized aspirin/trehalose, and control groups, and the gastric lesions were assessed on gastroscopy with the modified Lanza scale. Another 6 dogs were used to measure the plasma aspirin concentration by high-performance liquid chromatography after aspirin or lyophilized aspirin/trehalose administration. The results indicated that lyophilized aspirin/trehalose induced less gastric ulceration than aspirin despite maintaining therapeutic concentrations of plasma aspirin in both the groups. Lyophilized aspirin/trehalose might be a solution to decrease aspirin-induced gastropathy.

• 日本獣医学会の論文

著者

• SUZUKI Shigeki

  NEXT21

• Kayasuga Yuko

  Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo

• Sasaki Nobuo

  Department Of Pharmacology Faculty Of Veterinary Medicine Hokkaido University

• Mochizuki Manabu

  Department Of Electronics Faculty Of Engineering Yamanashi University:(present Address)sony

• CHUNG Ung-Il

  Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

• LIN Lee-Shuan

  Department of Veterinary Surgery, Graduate School of Agriculture and Life Science, The University of Tokyo

• SHIMOHATA Nobuyuki

  Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo

• KAMATA Hiroyuki

  NEXT21 K.K.

• ECHIGO Ryosuke

  Department of Veterinary Surgery, Graduate School of Agriculture and Life Science, The University of Tokyo

• MOCHIZUKI Manabu

  Department of Veterinary Surgery, Graduate School of Agriculture and Life Science, The University of Tokyo

• SASAKI Nobuo

  Department of Veterinary Surgery, Graduate School of Agriculture and Life Science, The University of Tokyo

• KAYASUGA Yuko

  Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

• Sasaki Nobuo

  Department of Biological Science and Technology, Tokyo University of Science

• SHIMOHATA Nobuyuki

  Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113–8655, Japan

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