Anti-Tumor Effect of Adenoviral Vector-Mediated p53 Gene Transfer on the Growth of Canine Osteosarcoma Xenografts in Nude Mice
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概要
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We evaluated the anti-tumor effect of adenoviral vector-mediated p53 gene therapy on the growth of canine osteosarcoma xenografts formed in nude mice. Nude mice were subcutaneously transplanted with cells of two P53 mutant canine osteosarcoma cell lines, POS and CHOS. The osteosarcoma xenografts were injected with either an adenoviral vector that expresses canine wild-type P53 (AxCA-cp53) or LacZ (AxCA-LacZ). Tumor growth was significantly inhibited in the xenografts injected with AxCA-cp53 in comparison to those injected with AxCA-LacZ or PBS during the observation period of 27 days. An increase of the amount of p21WAF1/CDKN1A mRNA, and the number of apoptotic cells was shown in the tumors injected with AxCA-cp53 in comparison to those injected with AxCA-LacZ or PBS. The present study revealed that the adenoviral vector-mediated p53 gene transfer had an anti-tumor effect in canine osteosarcoma xenografts formed in nude mice.
著者
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Goto-Koshino Yuko
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Ohno Koichi
Department Of Chemical Engineering Faculty Of Engineering Niigata University
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Tsujimoto Hajime
Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi
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Sasaki Nobuo
Department Of Pharmacology Faculty Of Veterinary Medicine Hokkaido University
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Mochizuki Manabu
Department Of Electronics Faculty Of Engineering Yamanashi University:(present Address)sony
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NISHIMURA Ryohei
Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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KANAYA Noriko
Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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YAZAWA Mitsuhiro
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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Sasaki Nobuo
Department of Biological Science and Technology, Tokyo University of Science
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