Reduced Coronary Vasodilation in Patients With Familial Hypercholesterolemia Following Intracoronary Injection of Isosorbide Dinitrate
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the relationship between the dilatation of angiographically non-steno-tic coronary artery segments in response to isosorbide dinitrate (ISDN), and serum lipids, 5 coronary segments in 7 patients with familial hypercholesterolemia (FH) and 43 patients with non-familial hypercholesterolemia (non-FH), who had either 1-or 2-vessel coronary heart disease, were investigated. The serum total cholesterol level was significantly greater in FH than in non-FH. Before and after the direct intracoronary injection of ISDN, coronary diameter was measured by a computer-assisted coronary angiography analysis system. The order of the dilative responses in coronary segments in non-FH patients (segments: #5> #11> #6> #13> #7) was exactly the same as the order of their original diameters, while the ratio of the increase in diameter (after/before ISDN injection) did not differ among any of the segments (mean: 1.08-fold increase). In the non-FH group, no correlation was found between the serum total cholesterol, triglyceride, low-density lipoprotein-cholesterol, or high-densi-ty lipoprotein-cholesterol, and the ratio of the coronary diameter after and before injection of ISDN. Moreover, hypercholesterolemia in non-FH did not affect the coronary dilative response to ISDN injection. In the FH group, although the original diameter of each segment did not differ from that in the non-FH group, the ratio of the diameter after and before injection of ISDN was significantly smaller in FH than in non-FH (p<0.01). These results suggest that a non-stenotic coronary artery in FH has a lower capacity for vasodilation in response to ISDN. Although hypercholesterolemia was excluded as a factor which may suppress the capacity for coronary dilation in non-FH, spontaneous hypercholesterolemia in FH may affect medial smooth muscle functions of the coronary artery.
- 社団法人日本循環器学会の論文
- 1995-11-20
著者
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SHIRAI Kazuyuki
Department of Cardiology, Fukuoka University Hospital
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SAKU Keijiro
Department of Cardiology, Fukuoka University Hospital
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Arakawa K
Fukuoka Univ.
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Arakawa Kikuo
Department Of Cardiology Fukuoka University School Of Medicine
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Arakawa Kikuo
2nd Dept. Of Int. Med. Fukuoka University School
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Arakawa K
Department Of Cardiology Fukuoka University School Of Medicine
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Arakawa Kikuo
Department Of Internal Medicine Fukuoka University. School Of Medicine
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Saku Keijiro
Department Of Cardiology Fukuoka University Faculty Of Medicine
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Arakawa Kikuo
福岡大学 内科
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NII Takanobu
Department of Internal Medicine, Karatsu Red Cross Hospital
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NII Takanobu
Second Department of Internal Medicine, School of Medicine, Fukuoka University
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Jimi Shiro
Pathology Fukuoka University School Of Medicine
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Shirai Kazuyuki
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Nii Takanobu
Second Department Of Internal Medicine School Of Medicine Fukuoka University
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Nii Takanobu
Department Of Internal Medicine Karatsu Red Cross Hospital
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Sasaki Nobuo
Departments of Internal Medicine, Fukuoka University School of Medicine
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Koga Nobuhiko
Department of Cardiology, Koga Hospital
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Shirai Kazuyuki
Department Of Cardiology Fukuoka University Hospital
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Arakawa Kikuo
Second Department Of Internal Medicine
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Arakawa Kikuo
Department Of 2nd Internal Medicine Fukuoka University
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Koga Nobuhiko
Department Of Cardiology Koga Hospital
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Sasaki Nobuo
Department Of Veterinary Surgery And Obstetrics Faculty Of Agriculture University Of Tokyo
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Sasaki Nobuo
Departments Of Internal Medicine Fukuoka University School Of Medicine
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Sasaki Nobuo
Department Of Pharmacology Faculty Of Veterinary Medicine Hokkaido University
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Saku Keijiro
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Arakawa Kikuo
The Second Department Of Internal Medicine Fuklloka University School Of Medicine
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Arakawa Kikuo
Second Department Of Internal Medicine Fukuoka University Hospital
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Sasaki Nobuo
Department of Biological Science and Technology, Tokyo University of Science
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