Clinical Significance of the Coronary Calcification Score by Multidetector Row Computed Tomography for the Evaluation of Coronary Stenosis in Japanese Patients

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概要

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• Background The coronary artery calcification (CAC) score measured by multidetector row computed tomography (MDCT) has emerged as a marker for predicting coronary artery disease (CAD). To evaluate the clinical significance of the CAC score, coronary artery stenosis as assessed by coronary angiography (CAG) was compared with the CAC score determined by MDCT, risk factors and medications. Methods and Results Subjects included 374 consecutive patients who underwent ECG-gate CT angiography using MDCT. The accuracy in patients with a CAC score ≥400 was 84%, and significantly lower than that in patients with a CAC score=0. In addition 92 patients (68 males, 24 females; mean age, 63±11 years) who underwent both MDCT and CAG within a 1-month period were selected for further investigation. Patients with significant coronary stenosis had a significantly higher CAC score than those without stenosis. In addition, a higher number of stenosed vessels was associated with a higher CAC score. The subjects were divided into 3 groups according to the CAC score: low (0-12), intermediate (13-444) and high (≥445). The CAC score was significantly associated with age, and plasma levels of total cholesterol and hemoglobinAlc, and logistic regression analysis revealed that significant coronary stenosis as assessed by CAG was most closely correlated with the CAC score (p=0.03). Conclusions The CAC score determined by MDCT can predict CAD independent of other factors, such as age, metabolic diseases and medications, when coronary stenosis can not be diagnosed because of severe calcification.

• 2006-08-20

著者

• SHIRAI Kazuyuki

  Department of Cardiology, Fukuoka University Hospital

• NISHIKAWA Hiroaki

  Department of Cardiology, Fukuoka University Hospital

• ZHANG Bo

  Department of Cardiology, Fukuoka University Hospital

• SAKU Keijiro

  Department of Cardiology, Fukuoka University Hospital

• Iwata Atsushi

  Department of Cardiology, Faculty of medicine, Fukuoka University

• Kawamura Akira

  Department of Cardiology, Faculty of medicine, Fukuoka University

• Miura Shin-ichiro

  Department of Cardiology, Faculty of medicine, Fukuoka University

• Mitsutake Ryoko

  Department of Cardiology, Fukuoka University School of Medicine

• Zhang Bo

  Department Of Cardiology Faculty Of Medicine Fukuoka University

• Iwata Atsushi

  Department Of Cardiology Faculty Of Medicine Fukuoka University

• Nishikawa Hiroaki

  Department Of Cardiology Faculty Of Medicine Fukuoka University

• Kumagai Koichiro

  Department of Cardiology, Fukuoka University School of Medicine

• Saku Keijiro

  Department Of Cardiology Fukuoka University Faculty Of Medicine

• Miura Shin-ichiro

  Department Of Cardiology Fukuoka University Faculty Of Medicine

• Matsunaga Akira

  Department Of Cardiology Fukuoka University

• Matsunaga Akira

  Department Of Anesthesiology And Critical Care Medicine Kagoshima University Graduate School Of Medi

• Kawamura Akira

  Department Of Cardiology Fukuoka University Faculty Of Medicine

• Niimura Hideya

  Department of Cardiology, Fukuoka University School of Medicine

• Nakashima Hideko

  Heart Rhythm Center Fukuoka Sanno Hospital

• Shirai Kazuyuki

  Department Of Cardiology Faculty Of Medicine Fukuoka University

• Matsumori Akira

  Department Of Cardiovascular Medicine Kyoto University Graduate Shool Of Medicine

• Shirai Kazuyuki

  Department Of Cardiology Fukuoka University Hospital

• Kumagai Koichiro

  Department Of 2nd Internal Medicine Fukuoka University

• Nakajima Hideko

  Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital

• Mitsutake Ryoko

  Department Of Cardiology Fukuoka University School Of Medicine

• Kawamura Akira

  Department Of Applied Electronics Faculty Of Electro-communications University Of Electro-communicat

• Saku Keijiro

  Department Of Cardiology Faculty Of Medicine Fukuoka University

• Miura Shin-ichiro

  Department Of Cardiology Faculty Of Medicine Fukuoka University

• Iwata Atsushi

  Department Of Biological Sciences Stanford University

• Zhang Bo

  Department Of Biochemistry Fukuoka University School Of Medicine

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