Long-Term Effects of Box Isolation on Sympathovagal Balance in Atrial Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
Background: Complete isolation of the posterior left atrium, including all pulmonary veins (box isolation), is a feasible and safe atrial fibrillation (AF) treatment method. Data on long-term effects of box isolation on autonomic function, however, remain limited. Methods and Results: A total of 92 patients (paroxysmal AF, n=76; persistent AF, n=16) undergoing box isolation with non-contact mapping were studied. Twenty-four-hours ambulatory electrocardiograms and transthoracic echocardiography were done at baseline and after 2 days, and at 3, 6 and 12 months. Autonomic functions were evaluated by means of heart rate variability (HRV). During a mean follow up of 16±5 months, no AF episodes were detected in 76 patients while AF recurred in 16. Significant long-term HRV attenuations were observed in all patients without AF recurrence, but not in those with AF recurrence. In patients without AF recurrence, the natural logarithm (Ln) high-frequency (HF) decreased significantly from 5.5±1.3 ms2 (before) to 4.2±0.9 ms2 (after 12 months, P<0.001) and the ratio of the low-frequency to HF power increased significantly from 2.4±2.0 ms2 (before) to 3.4±2.3 ms2 (after 12 months, P=0.05). LnHF was significantly lower in patients without than in those with AF recurrence during the 12-month period after ablation. Cardiac function improved significantly in patients without AF recurrence after box isolation. Conclusions: Changes in the sympathovagal balance with box isolation may contribute to AF prevention.
- 2010-05-25
著者
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SAKU Keijiro
Department of Cardiology, Fukuoka University Hospital
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Suyama Kazuhiro
福岡大学 2内
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Kuroki Syoji
福岡大学 医学部循環器科
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Kumagai Koichiro
Department Of Laboratory Medicine Fukuoka University Hospital
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Saku Keijiro
Department Of Cardiology Fukuoka University Faculty Of Medicine
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Saku Keijiro
福岡大学 医学研究科臨床研究科学
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YAMAGUCHI Yoshio
Department of Cardiology, Fukuoka University School of Medicine
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KUMAGAI Koichiro
Heart Rhythm Center, Fukuoka Sanno Hospital
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NAKASHIMA Hideko
Heart Rhythm Center, Fukuoka Sanno Hospital
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Kumagai Koichiro
Heart Rhythm Center Fukuoka Sanno Hospital
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Saku Keijiro
Department Of Cardiology Fukuoka University Hospital School Of Medicine
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Yamanouchi Yoshio
Department Of Cardiology Fukuoka University School Of Medicine
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Kumagai Koichiro
Department Of Cardiology Fukuoka University Hospital School Of Medicine
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Nakashima Hideko
Heart Rhythm Center Fukuoka Sanno Hospital
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Kumagai Koichiro
The Second Department Of Internal Medicine School Of Medicine Fukuoka University
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Yamaguchi Yoshio
Department Of Cardiology Kanazawa Medical University School Of Medicine
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Saku Keijiro
Department Of Cardiology Fukuoka University School Of Medicine Fukuoka University
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Kumagai Koichiro
Department Of 2nd Internal Medicine Fukuoka University
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Nakajima Hideko
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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Saku Keijiro
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Yamaguchi Yoshio
Department Of Cardiology Fukuoka University School Of Medicine
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Nakajima Hideko
The Second Department Of Internal Medicine School Of Medicine Fukuoka University
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Niimura Hideya
Department Of Cardiovascular Diseases Fukuoka University Chikushi Hospital
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Saku Keijiro
Department Of Internal Medicine Fukuoka University School Of Medicine
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Saku Keijiro
Department Of Internal Medicine School Of Medicine Fukuoka Universityr
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Yamaguchi Yoshio
Department of Applied Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
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