Quantitative Analysis of mRNA for 10 Different Drug Resistance Factors in Dogs with Lymphoma
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概要
- 論文の詳細を見る
Expression levels of ABCB1, ABCC1, Lung resistance-associated protein (LRP), ABCG2, p53, p21waf1, Bcl-2, CD40L, glutathione S-transferase alpha (GSTα), and O6-methylguanine-DNA-methyltransferase (MGMT) genes, and mutation of p53 gene were examined in 23 dogs with multicentric high-grade lymphoma to explore their association with drug resistance of the tumor cells. Dogs were divided into chemotherapy-sensitive (n=13) and -resistant (n=10) groups according to the response to a 6-month modified version of the University of Wisconsin (UW)-Madison chemotherapy protocol (UW-25), and expression levels of these factors and frequency of p53 gene mutation were compared between groups. No significant differences were observed in expression levels of each factor between groups. However, 4 dogs in the chemotherapy-resistant group showed high expression of ABCB1. No significant difference was observed in the frequency of p53 mutation between groups. A possible association of ABCB1 with resistance to UW-25 was shown, but no uniform mechanism associated with drug resistance could be identified in dogs with lymphoma.
著者
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TSUJIMOTO Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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TOMIYASU Hirotaka
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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TAKAHASHI Masashi
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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FUJINO Yasuhito
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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OHNO Koichi
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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束村 博子
名古屋大学 大学院生命農学研究科生殖科学研究分野
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束村 博子
名古屋大院生命農学
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束村 博子
名古屋大学大学院生命農学研究科生命技術科学専攻
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Goto-Koshino Yuko
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Fujino Yasuhito
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Tamamura H
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Tamamura Hirokazu
Dept. Of Molecular Recognition Inst. Of Biomaterials And Bioengineering Tokyo Medical And Dental Uni
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Ohno Koichi
Department Of Chemical Engineering Faculty Of Engineering Niigata University
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Takahashi Masashi
Department Of Chemistry Faculty Of Science Toho University
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Tsujimoto Hajime
Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi
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Tamamura H
Graduate School Of Pharmaceutical Sciences Kyoto University
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Takahashi Masashi
Department Of Animal And Grassland Research National Agricultural Center For Kyushu Okinawa Region
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Goto-Koshino Yuko
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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TOMIYASU Hirotaka
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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