Characterization of Monocyte-Derived Dendritic Cells from Cats Infected with Feline Immunodeficiency Virus
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概要
- 論文の詳細を見る
Dendritic cells (DCs) are professional antigen presenting cells (APCs) that possess an extraordinary capacity to stimulate naïve T cells and initiate a primary immune response. To develop a DC-based immunotherapy for feline immunodeficiency virus (FIV) infection, we carried out a study to characterize DCs from FIV-infected cats and compared the observations with those obtained from healthy controls. DCs were derived from adherent peripheral blood mononuclear cells that had been cultivated with recombinant feline interleukin 4, granulocyte macrophage colony-stimulating factor and heat-inactivated autologous plasma. Various parameters, such as cell morphology, surface phenotype, endocytosis and mixed leukocyte reaction (MLR), were analyzed to characterize feline DCs. Monocyte-derived DCs from FIV-infected cats as well as those from healthy controls showed a dendritic appearance and expressed an APC-like phenotype (CD1c+, CD80+ and MHC class II+). However, the expression level of CD1a was variable in the DCs derived from FIV-infected cats, although this was not the case in the DCs derived from the healthy controls. DCs from the FIV-infected cats retained the ability to take up dextran via the mannose receptor and also showed an apparent MLR, indicating that these cells could be useful in immunotherapy. In this study, monocytes obtained from FIV-infected cats could differentiate into functional DCs, suggesting that they might be used in a DC-based immunotherapy against FIV infection.
著者
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TSUJIMOTO Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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FUJINO Yasuhito
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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OHNO Koichi
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Goto-Koshino Yuko
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Mizukoshi Fuminori
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Baba Kenji
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Horiuchi Hiroshi
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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SETOGUCHI-MUKAI Asuka
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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MOORE Peter
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of C
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Fujino Yasuhito
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Baba Kenji
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Ohno Koichi
Department Of Chemical Engineering Faculty Of Engineering Niigata University
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Horiuchi Hiroshi
Department Of Endodontics And Periodontics Tohoku University School Of Dentistry
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Tsujimoto Hajime
Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi
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Mizukoshi Fuminori
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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SETOGUCHI-MUKAI Asuka
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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Baba Kenji
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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Mizukoshi Fuminori
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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MOORE Peter
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California
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SETOGUCHI-MUKAI Asuka
Department of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University
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