Prokinetic Effect of the 5-HT4R Agonist Mosapride on Canine Gastric Motility
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概要
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We assessed prokinetic action of gastroprokinetic agent, mosapride in dogs. Open-label cross-over study. Six healthy beagles were administered single oral mosapride at doses of 0.5, 0.75, 1, and 2 mg/kg 30 min prior to feeding, followed by 1-week interval. The motility index (MI) of gastric contraction was ultrasonographically evaluated by change rate of antral area and contraction number. Significant increases in MI were observed at doses of 0.75 mg/kg (mean ± SEM, 11.11 ± 0.19), 1 mg/kg (11.65 ± 0.34), and 2 mg/kg (12.04 ± 0.34), compared with that of the control (9.37 ± 0.51). Mosapride administration (2.0 mg/kg, BID) for 1 week had no adverse effects on blood tests or health of the animals. In conclusion, 0.75 to 2 mg/kg of mosapride produces gastric prokinetic actions without adverse effects.
著者
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Fujino Yasuhito
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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FUKUSHIMA Kenjiro
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The U
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Matsuura Shinobu
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Tsukamoto Atsushi
Department Of Veterinary Internal Medicine The University Of Tokyo
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Ohno Koichi
Department Of Chemical Engineering Faculty Of Engineering Niigata University
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Tsujimoto Hajime
Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi
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Maeda Shingo
Department Of Biochemistry The Cancer Institute Of The Japanese Foundation For Cancer Research
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MAEDA Shingo
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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NAKASHIMA Ko
Department of Veterinary Internal Medicine Graduate School of Agricultural and Life Sciences, The University of Tokyo
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FUKUSHIMA Kenjiro
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
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