Comparison between Immunohistochemistry and Genetic Clonality Analysis for Cellular Lineage Determination in Feline Lymphomas
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概要
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Clinical application of genetic clonality analysis by PCR has been available in feline lymphoma. However, it is in under dispute whether the analysis can be applied for cellular lineage determination. To evaluate utility of the analysis for lineage determination, the results between immunohistochemistry and the genetic analysis were compared. Based on the result with immunohistochemistry, sensitivity of the primer for IgH was 89% and specificity was 75%. Sensitivity of the primer for TCRγ was 25% and specificity was 100%. Cross-lineage IgH rearrangement was found in 25% of T-cell lymphomas. The present study suggests that the genetic analysis had better be applied as not a definite but an adjunctive tool for lineage determination in feline lymphomas.
著者
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Fujino Yasuhito
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
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Ohno Koichi
Department Of Chemical Engineering Faculty Of Engineering Niigata University
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Tsujimoto Hajime
Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi
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Sato Hirofumi
Department Of Applied Chemistry Osaka University
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Uchida Kazuyuki
Department Of Veterinary Pathology Graduated School Of Agricultural And Life Sciences The University
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SATO Hirofumi
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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