Morphological and Biochemical Changes During Aging and Photoaging of the Skin of C57BL/6J Mice
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概要
- 論文の詳細を見る
The differences between the dorsal skin of 11- and 16-week-old C57BL/6J mice were examined morphologically and biochemically. The dermis of the 16-week-old mice was thinner than that of the 11-week-old mice due to decreases in the amounts of soluble collagen and elastin. Next, the changes in dorsal skin exposed to UVA irradiation for 8 weeks (576 J/cm2) were examined in 3 (younger)- and 8 (older)-week-old C57BL/6J mice. The thickness of the dermis was not significantly different between the UVA-irradiated and control mice in either the younger or older group. The increase in the amount of collagen was related to the increase in the level of soluble collagen in the younger mice. In contrast, it was related to the increase in the level of insoluble collagen in the older mice. In the UVA-irradiated older mice, the activity of the latent form of MMP-13 was significantly higher than that in the control mice. These results suggest that aging and UVA-induced photoaging in the skin are histologically and biochemically different phenomena.
- 日本毒性病理学会の論文
著者
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Okada Taro
Department Of Marine Biotechnology Faculty Of Engineering Fukuyama University
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Sayama Ayako
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Soushin Tomomi
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Sayama Ayako
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Sayama Ayako
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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