Abnormal Myocardial Free Fatty Acid Utilization Deteriorates With Morphological Changes in the Hypertensive Heart
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概要
- 論文の詳細を見る
The left ventricle's morphological adaptation to high blood pressure is classified into 4 patterns based on mass and wall thickness. The geometric changes caused by maladaptation to pressure overload possibly relate to progression of contractile dysfunction with abnormal energy metabolism. The present study assessed whether the geometric adaptation of the left ventricle(LV)to high blood pressure relates to changes in myocardial energy metabolism, especially free fatty acid(FFA)utilization. Thirty-five patients with essential hypertension underwent echocardiography and dual isotopes myocardial scintigraphy using iodine-123 labeled 15-p-iodophenyl-3-(R, S)-methylpentadecanoic acid(BMIPP, an analogue of a FFA)and thallium-201(Tl-201). Systolic(endocardial fractional shortening ; %FS)and diastolic indices(the ratio of early to atrial filling waves ; E/A)of LV function were also assessed. Quantitative myocardial BMIPP uptake was evaluated by the BMIPP/Tl-201 myocardial uptake ratio(B/T). The subjects were divided into 4 groups based on LV mass and wall thickness : (1)concentric hypertrophy(CH), (2)eccentric hypertrophy(EH), (3)concentric remodeling(CR), and(4)normal geometry(N). The %FS was lower in the EH group than in the other groups. The mitral E/A ratio in the CH group was lowest. B/T was significantly decreased in the EH group compared with the N group(p<0.05). B/T correlated with the mitral E/A ratio significantly(p<0.05, r=0.42), whereas there was no relationship between %FS and B/T. These results indicate that the geometric changes occurring in hypertensive hearts strongly correlate with alternations in cardiac function and with abnormal myocardial FFA metabolism, and that the latter is associated with diastolic abnormality, but not with systolic function.
- 社団法人日本循環器学会の論文
- 2001-08-20
著者
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HORI Masatsugu
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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Horio Masaru
Ehime University
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NISHIO Mayu
Cardiovascular Division, Osaka Police Hospital
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Nanto Shinsuke
Cardiovascular Division, Kansai Rosai Hospital
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Nanto Shinsuke
Osaka Acute Coronary Insufficiency Study (OACIS) Group
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Nakano Susumu
Department Of Advanced Cardiovascular Therapeutics Osaka University Graduate School Of Medicine
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Nishio Mayu
Cardiovascular Division Of Kansai Rosai Hospital
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Fujita Masashi
Cardiovascular medicine, Osaka University
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Fujita Masashi
Cardiovascular Center Kansai Rosai Hospital
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Nagata Seiki
Cardiovascular Division, Kansai Rosai Hospital
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Kotani Junichi
Cardiovascular Division Of The Kansai Rosai Hospital
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Watanabe Tetsuya
Cardiovascular Division, Kansai Rosai Hospital
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Morozumi Takakazu
Cardiovascular Division, Kansai Rosai Hospital
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Watanabe Tetsuya
Cardiovascular Division Kansai Rosai Hospital
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Kusuoka H
Osaka National Hospital
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Kusuoka Hideo
大阪大学 医系研究 核医画像診断
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Kusuoka Hideo
Division Of Cardiology National Hospital Organization Osaka National Hospital
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Kusuoka Hideo
Institution For Clinical Research Osaka National Hospital
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Hori Masatsugu
Department Of Cardiology Osaka University Graduate School Of Medicine
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Nakayama Hiroyuki
Cardiovascular Division, Kansai Rosai Hospital
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Shimonagata Tsuyoshi
Cardiovascular Division, Osaka Prefectural Hospital
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Ohara Tomoki
Cardiovascular Division, Kansai Rosai Hospital
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Takano Yuzuru
Second Department of Internal Medicine, Kagawa University Medical School
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Shimonagata Tsuyoshi
Cardiovascular Division Osaka Prefectural Hospital
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Morozumi Takakazu
Cardiovascular Division Kansai Rosai Hospital
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Takano Yuzuru
Second Department Of Internal Medicine Kagawa University Medical School
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Ohara Tomoki
Kansai Rosai Hospital
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Ohara Tomoki
Osaka Police Hospital
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Nagata Seiki
Cardiology National Cardiovascular Center
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Ohara Tomoki
Center For Advanced Medical Engineering And Informatics Osaka University
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Nanto Shinsuke
Cardiovascular Division
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Nanto Shinsuke
Cardiac Intensive Care Unit Of Osaka Police Hospital
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Kataiwa Hideaki
Department Of Cardiology National Hospital Organization Osaka National Hospital
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Kusuoka Hideo
Division Of Tracer Kinetics Biomedical Research Canter Osaka University Medical School
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Kusuoka Hideo
First Dept. Of Midicine Osaka Univ. Medical School
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Nakayama Hiroyuki
Department Of Internal Medicine Osaka University Graduate School Of Medicine
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Matsuda Hikaru
Department Of Cardiology Osaka University Graduate School Of Medicine
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Kusuoka Hideo
National Hospital Organization Osaka National Hospital
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Kusuoka Hideo
Institute For Clinical Research Osaka National Hospital
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Horio Masaru
Division Of Health Sciences Department Of Functional Diagnostic Science Osaka University Graduate Sc
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Hori Masatsugu
Department Of Cardiology Ehime Prefectural Imabari Hospital
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Nishio Mayu
Cardiovascular Division Kansai Rosai Hospital
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Kusuoka Hideo
First Dept. Of Medicine Osaka University Medical School
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