Canine DNA Array as a Potential Tool for Combining Physiology and Molecular Biology : An Application for the Gene Expression Profile of Regional Ischemic Myocardium

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概要

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• The combining of molecular biology and physiology is essential for the further development of cardiovascular medicine, and DNA microarray is a useful tool for assessing multiple gene expressions. A canine DNA microarray has been designed and tested. Approximately 60 cardiovascular-related genes were cloned from newly developed canine cDNA libraries and spotted on slides. Using the arrays, the gene expression profiles of canine myocardium in were analyzed 2 protocols: (1) ischemic myocardium by 50% reduction of the coronary blood flow, and (2) necrotic myocardium caused by coronary artery ligation. Three hours after 50% flow reduction, cardio-vascular-related genes, including ecto-5'-nucleotidase, endothelin-1, PAI-1, and AT receptors, exhibited rapid alteration and there were many more altered genes than with the complete coronary occlusion. Irreversible ischemic damage without necrosis more strongly affected gene expressions in surviving myocardium than in fatally damaged myocardium. The canine DNA microarray is a useful tool for assessing the precise molecular events following changes in the pathophysiological conditions of the heart. (Circ J 2003; 67: 788-792)

• 社団法人日本循環器学会の論文
• 2003-08-20

著者

• HORI Masatsugu

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• TAKASHIMA Seiji

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Satomi Kazuhiro

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Node Koichi

  Department Of Cardiovascular And Renal Medicine Saga University

• Node Koichi

  Department Of Cardiovascular&renal Medicine Saga University Faculty Of Medicine

• Kitakaze Masafumi

  Cardiovascular Div. Of Medicine National Cardiovascular Center

• ASAKURA Masanori

  Department of Research and Development of Clinical Research, National Cardiovascular Center

• MINAMINO Tetsuo

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Asanuma Hiroshi

  Department of Cardiology, National Cardiovascular Center

• ASANO Yoshihiro

  Cardiovascular Division of the Department of Medicine, National Cardiovascular Center

• KIM Jiyoong

  Cardiovascular Division of the Department of Medicine, National Cardiovascular Center

• TOMOIKE Hitonobu

  Cardiovascular Division of Medicine, National Cardiovascular Center

• Shimazu Takashi

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Liao Yulin

  Cardiovascular Division Of Medicine National Cardiovascular Center

• Kim Jyonjoon

  Cardiovascular Division Of Medicine National Cardiovascular Center

• Kim Jiyoong

  Department Of Cardiology National Cardiovascular Center

• Minamino Tetsuo

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Asano Yoshihiro

  Cardiovascular Division Of The Department Of Medicine National Cardiovascular Center

• SANADA Shoji

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• LIAO Yulin

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• Sanada Shoji

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Kitamura Soichiro

  Cardiovascular Surgery, National Cardiovascular Center

• Shintani Yasunori

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• Shintani Yasunori

  Osaka University

• Kimu Jiyoong

  国立循環器病センター

• Asanuma Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Ogita Hisakazu

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• Takashima Seiji

  Department Of Cardiology Osaka University Graduate School Of Medicine

• Asano Yoshihiro

  Department Of Immunology And Host Defenses Ehime University Graduate School Of Medicine

• Takashima Seiji

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Shimazu Takashi

  The First Department Of Medicine Osaka University School Of Medicine

• Honma Tsuyoshi

  Phar-macology & Molecular Biology Research Laboratories, Sankyo CoLtd,

• Yorikane Ryosuke

  Phar-macology & Molecular Biology Research Laboratories, Sankyo CoLtd,

• Agai Akiko

  Cardiovascular Division of In-ternal Medicine, National Cardiovascular Center

• Ogida Hisakazu

  Department Of Internal Medicine And Therapeutics Osaka University

• Honma Tsuyoshi

  Phar-macology & Molecular Biology Research Laboratories Sankyo Coltd

• Asano Yoshihiro

  Department Of Cardiology Osaka University Graduate School Of Medicine

• Agai Akiko

  Cardiovascular Division Of In-ternal Medicine National Cardiovascular Center

• Tomoike Hitonobu

  Cardiology And Emergency Medicine National Cardiovascular Center

• Kitamura Soichiro

  Cardiovascular Division Of In-ternal Medicine National Cardiovascular Center

• Hori Masatsugu

  Department Of Cardiology Ehime Prefectural Imabari Hospital

• Shimazu Takashi

  Dep. Of 1st Med. Osaka University Medical School

• Shimazu Takashi

  Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine

• Yorikane Ryosuke

  Phar-macology & Molecular Biology Research Laboratories Sankyo Coltd

• Asakura Masanori

  Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center

• Node Koichi

  Department Of Cardiovascular & Renal Disease Medicine Saga University

• Hori Masatsugu

  Department Of Radiology National Center Hospital For Mental Nervous And Muscular Disorders National

• Node Kouichi

  Department Of Internal Medicine Aand Therapeutics Osaka University Graduate School Of Medicine

• KITAMURA Soichiro

  Cardiovascular and Transplant Surgery, National Cerebral and Cardiovascular Center

• Kim Jiyoong

  Cardiovascular Division of Medicine, National Cardiovascular Center

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