Hydrogen Peroxide-Induced Dermatitis in WBN/Kob-Ht Rats
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概要
- 論文の詳細を見る
Light and electron microscopic examinations were carried out on the dorsal skin to which hydrogen peroxide (HPO) (3, 6, and 10%) was topically applied for 7 consecutive days in Wistar rat-derived inbred WBN/Kob-Ht rats which have an autosomal dominant gene responsible for their characteristics of hypotrichosis. In addition to focal epidermal thickening, keratinocyte necrosis, dermal mononuclear cell infiltration and focal detachment of the epidermis from the dermis by fluid-filled spaces were detected. This is thought to be brought about by edema due to prominent capillary endothelial damage in the superficial dermis. The damage to keratinocytes and capillary endothelial cells was thought to be induced by HPO itself and free radicals generated by HPO. In addition, these changes were apparently more severe in WBN/Kob-Ht rats than in Wistar rats used as controls.
- 社団法人 日本実験動物学会の論文
著者
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Yasoshima A
Pharmaceutical Development Research Laboratory Tanabe Seiyaku Co. Ltd.
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Yasoshima Akira
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Yasoshima Akira
田辺製薬
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Yasoshima Akira
Lead Optimization Researh Laboratory Tanabe Seiyaku Co. Ltd.
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Doi Kunio
日本生物科学研究所
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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IWAMOTO Shoko
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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Iwamoto Shoko
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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