Effects of T-2 Toxin on the Expression of Connexin 32 in the Mouse Liver
スポンサーリンク
概要
- 論文の詳細を見る
In this study we investigated the effect of T-2 toxin (4 or 8 mg/kg/b.w.), a kind of trichothecene mycotoxins produced by the genus Fusalium, on the expression of connexin 32 (Cx32), a major protein of gap-junction, in mice. The area of total Cx32-positive spots on the immunostained section showed a tendency to be reduced from 6 to 36 hours after T-2 toxin inoculation (HAI), and it was significantly reduced at 36 HAI, irrespective of the dose of T-2 toxin. The value of Cx32 protein detected by Western blot analysis showed a tendency to be reduced from 3 to 48 HAI except at 6 HAI, and it was significantly reduced at 12 HAI, irrespective of the dose of T-2 toxin. Such reduction in Cx32 protein expression may be related to the depression of protein synthesis and induction of free radicals by T-2 toxin.
- 日本毒性病理学会の論文
- 2002-12-25
著者
-
鈴木 雅実
Safety Assessment Dep. Fuji Gotemba Res. Laboratories Chugai Pharmaceutical Co. Ltd.
-
Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
-
土井 邦雄
産業医総研
-
土井 邦雄
残留農薬研究所
-
鈴木 雅実
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
-
Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
-
KATAYAMA Kei-ichi
Dep. of Vet. Pathol., Grad. Sch. Agr. Life Sci., Univ. Tokyo
-
KATAYAMA Kei-ichi
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
-
MUTO Yukiko
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
-
SUZUKI Michio
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
-
TANI Yoshiro
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
-
Tani Yoshiro
東京大学 農学生命科研究科
-
谷 吉朗
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Tani Yoshiro
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Tani Yoshiro
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Muto Yukiko
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
-
谷 吉朗
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Doi Kunio
日本生物科学研究所
-
土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
-
Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
-
鈴木 雅実
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
Doi Kunio
Faculty Of Agriculture The University Of Tokyo
-
Katayama Kei-ichi
Dpt. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University Of Tok
-
Katayama Kei-ichi
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
-
Suzuki Masami
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
-
Doi K
Nippon Inst. For Biological Sci.
-
Suzuki Michio
Department Of Electronics Faculty Of Engineering Hokkaido University
-
Suzuki Michio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
関連論文
- A method for sampling and tissue preparation of the parathyroid glands in miniature pigs for toxicity studies
- Differences in bone responses to recombinant human granulocyte colony-stimulating factor between mice and rats
- Effects of a Single Injection of Recombinant Human Granulocyte Colony-stimulating Factor on Bone in Rats
- Relation between Marrow Hematopoietic Activity and Development of Bone Changes Induced in Rats by Recombinant Human Granulocyte Colony-stimulating Factor
- Involvement of Sex, Strain and Age Factors in High Fat Diet-Induced Obesity in C57BL/6J and BALB/cA Mice
- Depressive effects of immunosuppressant and anti-inflammatory drugs on HgCl_2-induced inflammatory lesions in Brown Norway rat(Immune system, Allergy, Proceedings of the 32nd Annual Meeting)
- MMP/TIMP activities in DMBA-induced rat mammary gland tumors(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Induction of Cytochrome P450 isozymes by phenobarbital in pregnant rat and fetal livers and placenta(Drug metabolism, Proceedings of the 32nd Annual Meeting)
- Recovery from pregnancy-induced down-regulation of cytochrome P450 isozymes (CYPs) protein levels in postpartum rat liver(Proceedings of the 32nd Annual Meeting)
- Histopathological changes in the brain of mouse fetuses by etoposide-administration(Proceedings of the 32nd Annual Meeting)
- DNA damage-induced toxicity and repair system in the developing fetal brain(Analysis of Toxicological Mechanisms : A Toxicogenomics Approach, Proceedings of the 32nd Annual Meeting)
- Age-Dependent Susceptibility to MPTP Neurotoxicity in C57BL Mice : A Tyrosine Hydroxylase-Immunohistochemical Evaluation
- The Susceptibility of Pregnant Mice to Encephalomyocarditis (EMC) Virus Infection on Different Days of Gestation
- 1-β-D-Arabinofuranosylcytosine (Ara-C)-induced Apoptosis in the Rat Fetal Tissues and Placenta
- Gene Expression Profiles in the Liver, Placenta and Fetal Liver in Pregnant Rats Treated with T-2 Toxin (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- DNA Damages and Changes in Proliferating Activity in the Dorsal Epidermis of UVB-Irradiated WBN/ILA-Ht Rats
- T-2 Toxin-Induced Morphological Changes in Pregnant Rats
- Effects of Exogenous Growth Hormone (GH)-Treatment on Carbon Tetrachloride (CCl_4)-Induced Acute Liver Injury in GH-Deficient Mini Rats
- Effects of T-2 Toxin on the Expression of Connexin 32 in the Mouse Liver
- Effects of T-2 Toxin Treatment on CCl_4-Induced Hepatic Necrosis in Mice
- Liver Responses to Repeated Doses of Carbon Tetrachloride in Mini and Wistar Rats
- O11-07 The Effects of Formaldehyde Inhalation on the Responses to Allergen Challenge in Brown Norway and Fischer 344 Rats
- P-49 Nivalenol-Induced Apoptosis in Lymphoid Organs of Mice.(Proceedings of the 27th Annual Meeting)
- P-48 Regulation of contact hypersensitivity in BALB/c mice repeatedly elicited with picryl-chloride.(Proceedings of the 27th Annual Meeting)
- Cell proliferative activity in the kidney of young growing rat analyzed using flash and cumulative labeling with bromodeoxyuridine
- Granulocyte Colony-Stimulating Factor Has No Adverse Effects on Atherosclerotic Lesions in High Cholesterol-Fed Miniature Swine(Pathology)
- Analysis by lectin histochemistry of kidney in Gottingen origin miniature pigs(Kidney, Urinary system, Proceedings of the 32nd Annual Meeting)
- Immunohistochemical detection of PTHrP and PTH/PTHrP receptor 1 on the odontoblastic reparative process after actinomycin D treatment in rats(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- A Decalcifying and Paraffin-embedding Method for Enzyme Histochemical and Immunohistochemical Studies of Bone(Proceedings of the 32nd Annual Meeting)
- COMBINATION OF FIXATION USING PLP FIXATIVE AND EMBEDDING IN PARAFFIN BY THE AMeX METHOD IS USEFUL FOR HISTOCHEMICAL STUDIES IN ASSESSMENT OF IMMUNOTOXICITY
- P12-11 The Combination of Fixation Using PLP Fixative and Embedding in Paraffin by the AMeX Method is Useful for Histopathological Studies in Assessment of Immunotoxicity.
- Teratologic Studies on Rat Perinates and Offspring from Dams Treated with Ethylnitrosourea (ENU)
- Histopathological Characteristics of Calcified Lesions of the Aortic Orifice (Ostium Aortae) in Dogs
- Tissue Distribution and Sequence of T-2 Toxin Induced-Apoptosis
- Changes in Location and Number of Tartrate-Resistant Acid Phosphatase (TRAP)-Positive Cells During the Development of Type II Collagen-Induced Arthritis in DBA/1J Mice
- Application of Flash and Cumulative Labeling with Bromodeoxyuridine for Analysis of Cell Kinetics of Bone Cells and Chondrocytes in Young Growing Rats
- Immunohistochemical Study on Type II Collagen-Induced Arthritis in DBA/1J Mice
- Immunohistochemical Study on Galactosamine-Induced Subacute Hepatitis in Rats of JCL: Wistar-TGN (ARGHGEN) 1Nts Strain (Mini rats)
- シカゴ大学短期留学10年をふりかえって
- Nuclearity and BrdU Labeling of Rat Hepatocytes in Cytocentrifuge Preparations of Freshly Isolated Hepatocytes with Cumulative Labeling of Bromodeoxyuridine
- D-Galactosamine Induced Hepatocyte Apoptosis is Inhabited in vivo and in Cell Culture by a Calcium Calmodulin Antagonist, Chlorpromazine, and a Calcium Channel Blocker, Verapamil
- Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies
- Development of a Novel Model for Streptozotocin-induced Renal Cell Tumors and Chronic Diabetes in Gottingen Minipigs
- Lobular Difference in Fibrotic Changes in Rat Cirrhosis Model Induced by Carbon Tetrachloride
- PLP-AMeX Method, Fixation Using PLP Fixative and Embedding in Paraffin by the AMeX Method, is Useful not only for Histochemistry but also In Situ Hybridization
- Immunohistochemical Identification of T- and B-Lymphocytes in Formalin-Fixed, Paraffin-Embedded Rat Sections
- Immunohistochemical Study on the Deposition of Apolipoprotein E in Cerebral and Islet Amyloidoses in Cynomolgus Monkeys (Macaca fascicularis)
- Immunohistochemical detection of anti-oxidative stress enzymes in the dog brain
- Immunohistochemical detection of tau protein in various non-human animal brains
- テオフィリンを反復投与したF344ラットにおける顎下腺の遺伝子発現の変化
- Changes in Salivary Gene Expression in F344 Rats Exposed to Theophylline
- Gene expression changes induced by theophylline in the salivary glands of rats(Proceedings of the 32nd Annual Meeting)
- Nitrofurazone-induced changes in the rat liver(Proceedings of the 32nd Annual Meeting)
- Immunohistochemical Detection of PTHrP and PTH/PTHrP Receptor 1 on the Odontoblastic Reparative Process after Actinomycin D Treatment in Rats
- Morphological Changes in Salivary Glands Induced by Theophylline in Rats
- Endothelial Hypertrophy in Acute Phase of Arteritis Induced by Fenoldopam, a Vasodilator, in Rats
- RESTITUTIVE RESPONSE OF MINI RAT LIVER TO INJURY INDUCED BY A SINGLE ORAL ADMINISTRATION OF THIOACETAMIDE
- 21C-02-1 Hepatic microsomal drug-metabolizing enzymes in male Nts:Minirats: cytochrome P450s and flavin-containing monooxygenase 1 (FMO1).
- Acetaminophen-Induced Hepatorenal Toxicity in High Fructose Diet-Fed Rats Is Sex-Dependent
- Age-Related Changes in Susceptibility of Mice to Low-Virulent Mouse Hepatitis Virus (MHV-2-CC) Infection
- HEMODYNAMIC AND ELECTROPHYSIOLOGICAL EFFECTS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN IN A HALOTHANE-ANESTHETIZED CANINE MODEL
- PRECLINICAL ELECTROPHYSIOLOGY ASSAYS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN
- 胸部CR画像における経時的差分画像法を用いたびまん性肺疾患の評価 : 模擬病変を用いた検出能と認識能の比較
- 507 びまん性肺疾患における経時的差分画像を用いた診断支援システムの研究 : 第2報 : 画像間の濃度差が差分画像に及ぼす影響とヒストグラム解析
- 506 びまん性肺疾患における経時的差分画像を用いた診断支援システムの研究 : 第1報 : サブトラクションシステムの構築と模擬病変による基礎実験
- Electron Microscopic Study of Subcapsular Cell Hyperplasia in the Adrenal Glands of IQI/Jic Mice
- Rapid Induction of Liver Cirrhosis in Mini Rats by Thioacetamide
- HISTOPATHOLOGICAL STUDY OF THE EFFECTS OF A SINGLE INTRATRACHEAL INSTILLATION OF SURFACE ACTIVE AGENTS ON LUNG IN RATS
- A Further Comparative Study on Early Histological Changes in Respiratory Tract of Brown Norway and Fischer 344 Rats after Short-Term Inhalation of Formaldehyde Aerosol
- Comparative Study on Picryl Chloride (PCL)-Induced Contact Dermatitis in Female IQI/Jic and BALB/c Mice
- The Role of CD4^+ T Cells in Biphasic Hind Limb Paralysis Induced by the D Variant of Encephalomyocarditis Virus (EMC-D) in DBA/2 Mice
- Nitrofurazone at a High Dose Induces Hepatocyte and Adrenal Necrosis in Rats
- Variation in Serum Creatine Phosphokinase Activity as Indicated in Two-Phase EMC-D Virus-Induced Myocarditis
- Development of Apoptosis and Changes in Apoptosis-related Genes Expression in the Mouse Thymus Following T-2 Toxin-inoculation
- T-2 Toxin Induced Skin Lesions in Hipotrichosis (Ht) Rats
- 5-Azacytidine-induced Apoptosis in the Central Nervous System of Developing Rat Fetuses
- "A-6 Immunohistochemical study on the component cells and extracellular matrix in galactosamine- induced acute hepatitis in rats.
- Changes in serum α1-acid glycoprotein and interleukin-8 in experimental lung injury in rats
- Glycoconjugate Expression in Follicle-Associated Epithelium (FAE) Covering the Nasal-Associated Lymphoid Tissue (NALT) in Specific Pathogen-Free and Conventional Rats
- Renal Tubulointerstitial Lesions in Mercuric Chloride-Treated Brown Norway Rats
- DORSAL SKIN LESIONS IN WBN/Kob-Ht RATS TOPICALLY TREATED WITH H_2O_2
- Lectinhistochemistry of Dorsal Skin of Wistar-derived Hypotrichotic WBN/Ila-Ht Rats
- Effects of Tacrolimus (FK506) on Encephalomyocarditic Virus-Induced Diabetes in Mice
- O-31 KINETICS OF MMPS AND THEIR REGULATORY FACTORS IN MERCURIC CHLORIDE-INDUCED TUBULOINTERSTITIAL LESIONS IN BROWN NORWAY RATS(Proceedings of the 27th Annual Meeting)
- 317.診断放射線における片面増感紙一片面乳剤フィルムの画像特性の評価(第40回総会会員研究発表)(片面システム・電子写真)
- Establishment and characterization of in vivo human tumor models in the NOD/SCID/γ_c^ mouse
- "P-40 The Age-related Difference in Bone Changes in Rats induced by Recombinant Granulocyte Colony-Stimulating Factor
- The Combination of Fixation Using PLP Fixative and Embedding in Paraffin by the AMeX Method is Useful for Immunohistochemical and Enzyme Histochemical Studies of the Lung
- T-2 Toxin-Induced Apoptosis and c-fos mRNA Expression in Con A-Stimulated Mouse Thymocyte Primary Cultures
- Picryl Chloride-Induced Contact Dermatitis in IQI/Jic Male Mice
- 5-Azacytidine-induced Apoptosis in Lymphoid and Hematopoietic Organs of Adult Mice
- Effects of Granulocyte Colony-Stimulating Factor on the Development of Inflammation in Bleomycin-Induced Lung Injury
- Morphological and Biochemical Changes During Aging and Photoaging of the Skin of C57BL/6J Mice
- Development of Apoptosis and Changes in Apoptosis-Related Genes Expression in the Thymus of Nivalenol-Treated Mice
- Early Ultrastructural Changes in the Dorsal Skin Epidermis of Wistar-Derived Hypotrichotic WBN/ILA-Ht Rats after UVB-Irradiation
- Renal Tubulointerstitial Lesions in Mercuric Chloride-Treated F344 Rats
- Comparison of Responses of Respiratory System to Cigarette Smoke Inhalation between Brown Norway and Fischer 344 Rats
- Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse
- Emphysematous Cystitis in a Chemically-Induced Diabetic Dog
- W2-3 USE OF PRIMARY CULTURED HEPATOCYTES FOR TOXICOLOGY