RESTITUTIVE RESPONSE OF MINI RAT LIVER TO INJURY INDUCED BY A SINGLE ORAL ADMINISTRATION OF THIOACETAMIDE
スポンサーリンク
概要
- 論文の詳細を見る
Mini rats are a transgenic rat strain carrying antisense gene for rat growth hormone (GH), resulting in retarded growth and a lower blood GH lavel (136±42.0 ng/mL) compared with that of age-matched parental strain Wistar rats (329±337 ng/mL). Mini rats have been used by several investigators as a GH deficiency model. In this work, we gave a single oral administration of thioacetamide (TAA), a hepatotoxicant, to both Mini rats and Wistar rats to ascertain the influence of GH deficiency on liver response to chemically induced injury and subsequent regeneration. TAA administration caused liver injury in both strains, with a greater extent of injury in Mini rats. Proliferation of bile epithelial cells and so-called oval cells was prominent at Day 3 in Mini rats only, and this change correlated well with serum total bilirubin concentrations. Antibody against Ki-67 antigen revealed that cellular proliferation after TAA-induced liver injury was suppressed but prolonged in the Mini rat liver. Although hepatic stellate cells and Kupffer cells/macrophages were more abundant in the livers of TAA-treated Mini rats, the hepatic expression patterns of hepatocyte growth factor and transforming growth factor β_1 were comparable to those of Wistar rats. Insulin-like growth factor-I gene expression was significantly reduced in the Mini rat liver. Our results imply that a lower GH level may exacerbate chemically induced liver injury, enhance infiltration/proliferation of non-parenchymal cells, suppress regeneration of hepatocytes, and induce proliferation of bile epithelial cells and oval cells when the liver is injured by TAA.
- 日本トキシコロジー学会の論文
- 2001-02-20
著者
-
Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
-
土井 邦雄
産業医総研
-
土井 邦雄
残留農薬研究所
-
Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
-
Tani Yoshiro
東京大学 農学生命科研究科
-
谷 吉朗
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Tani Yoshiro
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Tani Yoshiro
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
谷 吉朗
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Tani Yoshiro
Medical Safety Research Laboratories Sankyo Co. Ltd
-
Doi Kunio
日本生物科学研究所
-
Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
-
TANI Yshiro
Medicinal Safety Research Laboratories
-
KAMAI Yoko
Medicinal Safety Research Laboratories
-
YAMATE Koji
Biological Research Laboratories, Sankyo Co., Ltd.
-
MIZUNO Hatsue
Medicinal Safety Research Laboratories
-
YAMAMOTO Hideki
Medicinal Safety Research Laboratories
-
HOSOKAWA Tsunemichi
Medicinal Safety Research Laboratories
-
Yamamoto H
Medicinal Safety Research Laboratories
-
Kamai Yoko
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Yamate Koji
Biological Research Laboratories Sankyo Co. Ltd.
-
水野 初枝
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Yamamoto Hideki
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
細川 常通
Medicinal Safety Research Laboratories
-
谷 吉朗
三共
-
Doi K
Nippon Inst. For Biological Sci.
関連論文
- Differences in bone responses to recombinant human granulocyte colony-stimulating factor between mice and rats
- Involvement of Sex, Strain and Age Factors in High Fat Diet-Induced Obesity in C57BL/6J and BALB/cA Mice
- Depressive effects of immunosuppressant and anti-inflammatory drugs on HgCl_2-induced inflammatory lesions in Brown Norway rat(Immune system, Allergy, Proceedings of the 32nd Annual Meeting)
- MMP/TIMP activities in DMBA-induced rat mammary gland tumors(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Induction of Cytochrome P450 isozymes by phenobarbital in pregnant rat and fetal livers and placenta(Drug metabolism, Proceedings of the 32nd Annual Meeting)
- Recovery from pregnancy-induced down-regulation of cytochrome P450 isozymes (CYPs) protein levels in postpartum rat liver(Proceedings of the 32nd Annual Meeting)
- Histopathological changes in the brain of mouse fetuses by etoposide-administration(Proceedings of the 32nd Annual Meeting)
- DNA damage-induced toxicity and repair system in the developing fetal brain(Analysis of Toxicological Mechanisms : A Toxicogenomics Approach, Proceedings of the 32nd Annual Meeting)
- Age-Dependent Susceptibility to MPTP Neurotoxicity in C57BL Mice : A Tyrosine Hydroxylase-Immunohistochemical Evaluation
- The Susceptibility of Pregnant Mice to Encephalomyocarditis (EMC) Virus Infection on Different Days of Gestation
- 1-β-D-Arabinofuranosylcytosine (Ara-C)-induced Apoptosis in the Rat Fetal Tissues and Placenta
- Gene Expression Profiles in the Liver, Placenta and Fetal Liver in Pregnant Rats Treated with T-2 Toxin (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- DNA Damages and Changes in Proliferating Activity in the Dorsal Epidermis of UVB-Irradiated WBN/ILA-Ht Rats
- T-2 Toxin-Induced Morphological Changes in Pregnant Rats
- Effects of Exogenous Growth Hormone (GH)-Treatment on Carbon Tetrachloride (CCl_4)-Induced Acute Liver Injury in GH-Deficient Mini Rats
- Effects of T-2 Toxin on the Expression of Connexin 32 in the Mouse Liver
- Effects of T-2 Toxin Treatment on CCl_4-Induced Hepatic Necrosis in Mice
- Liver Responses to Repeated Doses of Carbon Tetrachloride in Mini and Wistar Rats
- O11-07 The Effects of Formaldehyde Inhalation on the Responses to Allergen Challenge in Brown Norway and Fischer 344 Rats
- P-49 Nivalenol-Induced Apoptosis in Lymphoid Organs of Mice.(Proceedings of the 27th Annual Meeting)
- P-48 Regulation of contact hypersensitivity in BALB/c mice repeatedly elicited with picryl-chloride.(Proceedings of the 27th Annual Meeting)
- Immunohistochemical detection of PTHrP and PTH/PTHrP receptor 1 on the odontoblastic reparative process after actinomycin D treatment in rats(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- Teratologic Studies on Rat Perinates and Offspring from Dams Treated with Ethylnitrosourea (ENU)
- Tissue Distribution and Sequence of T-2 Toxin Induced-Apoptosis
- Changes in Location and Number of Tartrate-Resistant Acid Phosphatase (TRAP)-Positive Cells During the Development of Type II Collagen-Induced Arthritis in DBA/1J Mice
- Application of Flash and Cumulative Labeling with Bromodeoxyuridine for Analysis of Cell Kinetics of Bone Cells and Chondrocytes in Young Growing Rats
- Immunohistochemical Study on Type II Collagen-Induced Arthritis in DBA/1J Mice
- Immunohistochemical Study on Galactosamine-Induced Subacute Hepatitis in Rats of JCL: Wistar-TGN (ARGHGEN) 1Nts Strain (Mini rats)
- シカゴ大学短期留学10年をふりかえって
- D-Galactosamine Induced Hepatocyte Apoptosis is Inhabited in vivo and in Cell Culture by a Calcium Calmodulin Antagonist, Chlorpromazine, and a Calcium Channel Blocker, Verapamil
- Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies
- P6-52 Gene expression analysis in mouse primary cultured hepatocytes exposed to streptozotocin(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Immunohistochemical Study on the Deposition of Apolipoprotein E in Cerebral and Islet Amyloidoses in Cynomolgus Monkeys (Macaca fascicularis)
- Immunohistochemical detection of anti-oxidative stress enzymes in the dog brain
- Immunohistochemical detection of tau protein in various non-human animal brains
- テオフィリンを反復投与したF344ラットにおける顎下腺の遺伝子発現の変化
- Changes in Salivary Gene Expression in F344 Rats Exposed to Theophylline
- Gene expression changes induced by theophylline in the salivary glands of rats(Proceedings of the 32nd Annual Meeting)
- Nitrofurazone-induced changes in the rat liver(Proceedings of the 32nd Annual Meeting)
- Immunohistochemical Detection of PTHrP and PTH/PTHrP Receptor 1 on the Odontoblastic Reparative Process after Actinomycin D Treatment in Rats
- Morphological Changes in Salivary Glands Induced by Theophylline in Rats
- Endothelial Hypertrophy in Acute Phase of Arteritis Induced by Fenoldopam, a Vasodilator, in Rats
- RESTITUTIVE RESPONSE OF MINI RAT LIVER TO INJURY INDUCED BY A SINGLE ORAL ADMINISTRATION OF THIOACETAMIDE
- Early Ultrastructural Changes in the Dorsal Skin Epidermis of W5istar-Derived Hypotrichotic WBN/ILA-Ht Rats after UVB-Irradiation
- T-2 Toxin-Induced Apoptosis and c-fos mRNA Expression in Con A-Stimulated Mouse Thymocyte Primary Cultures
- 5-Azacytidine-induced Apoptosis in Lymphoid and Hematopoietic Organs of Adult Mice
- Renal Tubulointerstitial Lesions in Mercuric Chloride—Treated F344 Rats
- The Combination of Fixation Using PLP Fixative and Embedding in Paraffin by the AMeX Method is Useful for Immunohistochemical and Enzyme Histochemical Studies of the Lung
- 21C-02-1 Hepatic microsomal drug-metabolizing enzymes in male Nts:Minirats: cytochrome P450s and flavin-containing monooxygenase 1 (FMO1).
- Acetaminophen-Induced Hepatorenal Toxicity in High Fructose Diet-Fed Rats Is Sex-Dependent
- Age-Related Changes in Susceptibility of Mice to Low-Virulent Mouse Hepatitis Virus (MHV-2-CC) Infection
- 胸部CR画像における経時的差分画像法を用いたびまん性肺疾患の評価 : 模擬病変を用いた検出能と認識能の比較
- 507 びまん性肺疾患における経時的差分画像を用いた診断支援システムの研究 : 第2報 : 画像間の濃度差が差分画像に及ぼす影響とヒストグラム解析
- 506 びまん性肺疾患における経時的差分画像を用いた診断支援システムの研究 : 第1報 : サブトラクションシステムの構築と模擬病変による基礎実験
- Electron Microscopic Study of Subcapsular Cell Hyperplasia in the Adrenal Glands of IQI/Jic Mice
- Subcapsular Cell Hyperplasia and Mast Cell Infiltration in the Adrenal Cortex of Mice: Comparative Study in 7 Inbred Strains
- Correlation of Mast Cells with Spindle Cell Hyperplasia in the Adrenal Cortex of IQI/Jic Mice
- Sequence of and Regional Difference in Apoptotic Index in the Mouse Gastrointestinal Mucous Epithelia after T-2 Toxin Inoculation
- Rapid Induction of Liver Cirrhosis in Mini Rats by Thioacetamide
- A Further Comparative Study on Early Histological Changes in Respiratory Tract of Brown Norway and Fischer 344 Rats after Short-Term Inhalation of Formaldehyde Aerosol
- Comparative Study on Picryl Chloride (PCL)-Induced Contact Dermatitis in Female IQI/Jic and BALB/c Mice
- The Role of CD4^+ T Cells in Biphasic Hind Limb Paralysis Induced by the D Variant of Encephalomyocarditis Virus (EMC-D) in DBA/2 Mice
- Histological Characteristics of Respiratory System in Brown Norway Rat
- Nitrofurazone at a High Dose Induces Hepatocyte and Adrenal Necrosis in Rats
- Age-Related Histochemical and Ultrastructural Changes in Renal Glomerular Mesangium of APA Hamsters
- Ultrastructure of the Dorsal Skins of Hairless Descendants Derived from Mexican Hairless Dogs
- Dermal Histology of Hairless Rat Derived from Wistar Strain
- EFFECTS OF T-2 TOXIN ON HEPATOCYTE PROLIFERATION IN NORMAL MICE
- Detection of Viral RNA by Electron Microscopic In situ Hybridization (ISH-EM) in The Germinal Epithelium of Mice Infected with Encephalomyocarditis (EMC) Virus
- Variation in Serum Creatine Phosphokinase Activity as Indicated in Two-Phase EMC-D Virus-Induced Myocarditis
- Involvement of Macrophages in the Development of Encephalomyocarditis (EMC) Virus-Induced Diabetes in Mice
- T-2 Toxin and Apoptosis
- Hydrogen Peroxide-Induced Dermatitis in WBN/Kob-Ht Rats
- Development of Apoptosis and Changes in Apoptosis-related Genes Expression in the Mouse Thymus Following T-2 Toxin-inoculation
- T-2 Toxin Induced Skin Lesions in Hipotrichosis (Ht) Rats
- 5-Azacytidine-induced Apoptosis in the Central Nervous System of Developing Rat Fetuses
- Process of the Development of T-2 Toxin-induced Apoptosis in the Lymphoid Organs of Mice
- "A-15 Sequence of T-2 toxin- induced apoptosis in the lymphoid organs of mice
- "A-6 Immunohistochemical study on the component cells and extracellular matrix in galactosamine- induced acute hepatitis in rats.
- Environmental Effect on Eosinophilic Granulomatous Pneumonia (EGP) in Brown Norway Rats
- Glycoconjugate Expression in Follicle-Associated Epithelium (FAE) Covering the Nasal-Associated Lymphoid Tissue (NALT) in Specific Pathogen-Free and Conventional Rats
- Renal Tubulointerstitial Lesions in Mercuric Chloride-Treated Brown Norway Rats
- DORSAL SKIN LESIONS IN WBN/Kob-Ht RATS TOPICALLY TREATED WITH H_2O_2
- Lectinhistochemistry of Dorsal Skin of Wistar-derived Hypotrichotic WBN/Ila-Ht Rats
- Effects of Tacrolimus (FK506) on Encephalomyocarditic Virus-Induced Diabetes in Mice
- O-31 KINETICS OF MMPS AND THEIR REGULATORY FACTORS IN MERCURIC CHLORIDE-INDUCED TUBULOINTERSTITIAL LESIONS IN BROWN NORWAY RATS(Proceedings of the 27th Annual Meeting)
- Diurnal Changes in Intraepithelial Lymphocytes (IELs) in the Small Intestine of Mice
- 317.診断放射線における片面増感紙一片面乳剤フィルムの画像特性の評価(第40回総会会員研究発表)(片面システム・電子写真)
- "P-40 The Age-related Difference in Bone Changes in Rats induced by Recombinant Granulocyte Colony-Stimulating Factor
- Gene expression profiling in streptozotocin treated mouse liver using DNA microarray (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Silver Selectivity of Novel Monoazapolythioether Derivatives Bearing a Hydrazone Group in the Solvent Extraction
- T-2 Toxin-Induced Apoptosis and c-fos mRNA Expression in Con A-Stimulated Mouse Thymocyte Primary Cultures
- Picryl Chloride-Induced Contact Dermatitis in IQI/Jic Male Mice
- 5-Azacytidine-induced Apoptosis in Lymphoid and Hematopoietic Organs of Adult Mice
- Effects of Granulocyte Colony-Stimulating Factor on the Development of Inflammation in Bleomycin-Induced Lung Injury
- Morphological and Biochemical Changes During Aging and Photoaging of the Skin of C57BL/6J Mice
- Development of Apoptosis and Changes in Apoptosis-Related Genes Expression in the Thymus of Nivalenol-Treated Mice
- Early Ultrastructural Changes in the Dorsal Skin Epidermis of Wistar-Derived Hypotrichotic WBN/ILA-Ht Rats after UVB-Irradiation
- Renal Tubulointerstitial Lesions in Mercuric Chloride-Treated F344 Rats
- Comparison of Responses of Respiratory System to Cigarette Smoke Inhalation between Brown Norway and Fischer 344 Rats