Environmental Effect on Eosinophilic Granulomatous Pneumonia (EGP) in Brown Norway Rats
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概要
- 論文の詳細を見る
The prevalence of eosinophilic granulomatous pneumonia (EGP) is well known in Brown Norway (BN) rats. In this study, age-related changes in the incidence and severity of EGP in 4 to 20 weeks old BN rats were examined under two different housing conditions (isolator cages without woodchips and common cages with woodchips for bedding) in a SPF animal room in Charles River Japan Inc. A routine microbiological survey gave negative results to any specific pathogens tested. As a result of histopathological examination, there were no lung lesions observed at the age of 4 weeks. EGP developed at and after the age of 7 weeks, but the incidence and severity of EGP showed no age-related changes under both housing conditions. These findings suggest that EGP in BN rats may be a hypersensitivity response of strain-specific nature as reported by Albers and Clifford.
- 日本毒性病理学会の論文
- 2003-06-30
著者
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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Ohtsuka Ryoichi
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Ohtsuka Ryoichi
Department Of Biomedical Science The University Of Tokyo
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Doi Kunio
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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