Age-Related Histochemical and Ultrastructural Changes in Renal Glomerular Mesangium of APA Hamsters
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概要
- 論文の詳細を見る
Syrian hamsters of the APA strain (APA hamsters) develop spontaneous mesangial thickening in the renal glomeruli from an early age. They also develop focal and segmental glomerulosclerosis (FSG) at and after 6 months of age. In this study, histopathological, histochemical and electron microscopical examinations were conducted to clarify the age-related renal glomerular changes in spontaneous FSG of APA hamsters. Histopathological analysis revealed that expansion of the mesangial region and thickening of the glomerular basement membrane (GBM) in the glomeruli of APA hamsters progressed with age. These age-related changes appeared earlier in male animals. Immunohistochemical analysis suggested that type IV collagen was responsible for the expansion of the mesangial region and thickening of the GBM. In lectin histochemical analysis, positive sites for WGA with and without neuraminidase pretreatment and PNA with neuraminidase pretreatment were detected mainly in podocytes and were expanded with age. Ultrastructurally, the increase in basement membrane-like materials in the mesangial matrix, development of intracellular organella of mesangial cells and migration of a part of the mesangial cell cytoplasm into the GBM were observed at and after 6 months of age. These features suggested that mesangial cells played an important role in the age-related expansion of the mesangial region and thickening of the GBM.
- 社団法人 日本実験動物学会の論文
- 1996-10-01
著者
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土井 邦雄
残留農薬研究所
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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YAMANOUCHI Jun
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, the University
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Doi Kunio
日本生物科学研究所
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土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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ITAGAKI Shinichi
Department of Biomedical Science, School of Agricultural and Life Sciences, University of Tokyo
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NISHIDA Etsuko
Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Yamanouchi Jun
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Or
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OGATA Seiya
Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo
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板垣 慎一
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science The University Of Tokyo
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Nishida Etsuko
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculyure The University Of Tokyo
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Ogata Seiya
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Itagaki Shinichi
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Nishida Etusko
Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo
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