Detection of Viral RNA by Electron Microscopic In situ Hybridization (ISH-EM) in The Germinal Epithelium of Mice Infected with Encephalomyocarditis (EMC) Virus
スポンサーリンク
概要
- 論文の詳細を見る
Electron microscopic in situ hybridization (ISH-EM) was first applied to the detection of viral RNA in the germinal epithelium of mice inoculated i.p. with 105 plaque-forming units/mouse of the D variant of encephalomyocarditis virus (EMC-D). Signals of viral RNA were first detected in a small number of Sertoli cells showing mild degeneration at 2 days post inoculation, and 2 days later, they were also detected in germinal cells and spermatogonia when Sertoli cells showed prominent degeneration. The results clearly demonstrated that the first site of viral attack in the germinal epithelium was Sertoli cell in the case of EMC-D-induced mouse orchitis.
- 社団法人 日本実験動物学会の論文
著者
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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ITAGAKI Shin-ichi
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
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土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Takeda Makio
The Institute of Environmental Toxicology
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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武田 真記夫
Institute Of Environmental Toxicology
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Takeda M
Kobe-university
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Itagaki S
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Hirasawa Kazuo
Ina Research Laboratory Kitayama Labes Co. Ltd.
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土井 邦雄
シカゴ大学カートロマン放射線像研究所
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Doi Kunio
Faculty Of Agriculture The University Of Tokyo
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武田 真記夫
The Institute of Environmental Toxicology
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Takeda Makio
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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UENO Aito
Department of Veterinary Pathology, The University of Tokyo
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HIROSAWA Kensuke
Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo
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Hirosawa Kensuke
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Hirasawa Kensuke
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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板垣 慎一
Department Of Biomedical Science Graduate School Of Agricultural And Life Sciences The University Of
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Itagaki Shin-ichi
Department Of Biomedical Science The University Of Tokyo
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Doi K
Faculty Of Agriculture The University Of Tokyo
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
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Ueno Aito
Department Of Veterinary Pathology The University Of Tokyo
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Itagaki Shin-ichi
Department Of Biomedical Science Faculty Of Agriculyure The University Of Tokyo
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Takeda Makio
Department of Biological and Environmental Sciences, Graduate School of Agricultural Science, Kobe University
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