DNA Damages and Changes in Proliferating Activity in the Dorsal Epidermis of UVB-Irradiated WBN/ILA-Ht Rats
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概要
- 論文の詳細を見る
DNA damages and changes in proliferating activity of keratinocytes in rat dorsal skin exposed to a high-dose ultraviolet B (UVB) irradiation were examined immunohistochemically. The number of cells that express cyclobutane pyrimidine dimer (CPD), which represents UVB-induced DNA damage, started to increase at 1 h after irradiation, peaked at 3 h and thereafter decreased rapidly. Bromodeoxyuridine (BrdU)-labeling index (LI) was lower than that in control group from 1 to 24 h after irradiation, and it returned to the control level at 36 h. Topoisomerase II α (TIIα)-LI was significantly lower than that in control group from 1 to 12 h and showed the lowest value at 9 h. Thereafter, it increased and showed higher values than that in control group at 24, 36 and 72 h. These results suggest that DNA damages in survival basal keratinocytes may be repaired during 12 to 24 h and cell growth of keratinocytes may be arrested at least at 24 h.
- 日本毒性病理学会の論文
- 2003-09-30
著者
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
産業医総研
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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UETSUKA Koji
Dept. VetPathol., Univ. Tokyo
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OKADA Taro
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Okada Taro
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Okada Taro
Department Of Marine Biotechnology Faculty Of Engineering Fukuyama University
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Nakayama Hiroyuki
東京大学 農学生命科学研究科獣医病理学
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Doi Kunio
日本生物科学研究所
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土井 邦雄
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Uetsuka K
Univ. Tokyo Tokyo
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Uetsuka Koji
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Doi Kunio
Faculty Of Agriculture The University Of Tokyo
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Doi K
Univ. Tokyo Tokyo Jpn
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Uetsuka K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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Nakayama Hiroyuki
Laboratory Of Veterinary Pathology Graduate School Of Agriculture And Life Science The University Of
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Nakayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Doi K
Nippon Inst. For Biological Sci.
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Nkayama Hiroyuki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Science The University O
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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