Teratologic Studies on Rat Perinates and Offspring from Dams Treated with Ethylnitrosourea (ENU)
スポンサーリンク
概要
- 論文の詳細を見る
Ethylnitrosourea (ENU), a well known DNA alkylating agent, induces anomalies in the central nervous system (CNS), craniofacial tissues, limbs and male reproductive organs. Recently we clarified that excess cell death caused by apoptosis occurred in these organs and tissues of rat fetuses from dams treated with ENU at day 13 of gestation (GD13). In this study, we examined fetuses at GD21 and offspring at 10 weeks of age after ENU administration to pregnant rats at GD13 in order to clarify the relationship between ENU-induced apoptosis in the fetal tissues and teratogenicity of ENU. Severe intrauterine growth retardation was observed in the ENU group, and the body weight of the offspring in the ENU group was significantly lower than that of the control group throughout the experiment. In addition, a high incidence of microencephaly, ectrodactyly and curved caudal vertebrae was observed in the offspring from dams treated with ENU at GD13. Judging from the results of our previous and present studies, it was strongly suggested that ENU-induced apoptosis in rat fetal tissues may play an important role in the induction of anomalies in the corresponding tissues.
- 社団法人 日本実験動物学会の論文
著者
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鈴木 雅実
Safety Assessment Dep. Fuji Gotemba Res. Laboratories Chugai Pharmaceutical Co. Ltd.
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Doi K
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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土井 邦雄
産業医総研
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土井 邦雄
残留農薬研究所
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Nakayama H
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences University Of T
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鈴木 雅実
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Doi Kunio
Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
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NAKAYAMA Hiroyuki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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KATAYAMA Kei-ichi
Dep. of Vet. Pathol., Grad. Sch. Agr. Life Sci., Univ. Tokyo
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KATAYAMA Kei-ichi
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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SUZUKI Michio
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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OHTSUKA Ryoichi
Department of Veterinary Pathology, The University of Tokyo
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Kiatipattanasakul W
Univ. Tokyo Tokyo Jpn
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Kiatipattanasakul Wijit
東京大学 農生命科研究
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Nakayama H
Dep. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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ISHIGAMI Noriaki
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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KIATIPATTANSAKUI Wijit
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
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Ohtsuka Ryoichi
The Institute Of Environmental Toxicology
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大塚 亮一
Institute Of Environmental Toxicology
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Ohtsuka Ryoichi
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Ohtsuka Ryoichi
Department Of Biomedical Science The University Of Tokyo
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Doi Kunio
日本生物科学研究所
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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鈴木 雅実
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Katayama Kei-ichi
Dpt. Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University Of Tok
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Katayama Kei-ichi
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Kiatipattanasakul Wijit
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Suzuki Masami
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Doi K
Nippon Inst. For Biological Sci.
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Ishigami Noriaki
Department Of Veterinary Pathology Graduate School Of Agricultural And Life Sciences The University
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Suzuki Michio
Department Of Electronics Faculty Of Engineering Hokkaido University
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Suzuki Michio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Nakayama Hiroyuki
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
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