Granulocyte Colony-Stimulating Factor Has No Adverse Effects on Atherosclerotic Lesions in High Cholesterol-Fed Miniature Swine(Pathology)
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概要
- 論文の詳細を見る
Granulocyte colony-stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells, and expected to restore cardiac function for patients with coronary artery diseases as a consequence of progression of atherosclerosis. Safety issues related to the administration of G-CSF to these patients, however, are still under study. The animal model for atherosclerosis was produced by feeding miniature swine a high-cholesterol diet for 3 months. G-CSF (5 or 10μg/kg/day) was given to the animal model by daily subcutaneous injections for 10 days and 20 main arteries were evaluated pathologically. In addition, the general toxicological effects were studied on clinical signs, body weight, hematology, blood chemistry and pathology. In the G-CSF-treated groups, a variety of changes related to the major pharmacological activity of G-CSF including an increase in white blood cell (WBC) counts were observed. In many arteries, atherosclerotic lesions similar to Type I-V of the proposed classification by the American Heart Association were observed. No effects of the G-CSF treatment were seen on the histopathological findings, incidence, severity or distribution of atherosclerotic lesions. In addition, no infiltration of neutrophils to the lesions was observed. These findings suggest that the administration of G-CSF causes neither exacerbation or modification of atherosclerotic lesions nor adverse changes despite that a sufficient increase in WBC counts could be achieved in the peripheral blood.
- 社団法人日本獣医学会の論文
- 2008-09-25
著者
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鈴木 雅実
Safety Assessment Dep. Fuji Gotemba Res. Laboratories Chugai Pharmaceutical Co. Ltd.
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鈴木 雅実
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Miyoshi Akio
Safety Assessment Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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KATO Atsuhiko
Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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Yamazaki Masaki
中外製薬富士御殿場研究所
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Fujii Etsuko
中外製薬富士御殿場研究所
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Fujii Etsuko
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Fujii Etsuko
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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Fujii Etsuko
Department Of Veterinary Pathology Faculty Of Agriculture Iwate University
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ITO Tsuneo
Chugai Research Institute for Medical Science, Inc.
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TAKAI Hirotake
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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MIYOSHI Akio
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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YAMAZAKI Masaki
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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ADACHI Kenji
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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KATAGIRI Kouichi
Chugai Research Institute for Medical Science, Inc.
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ARAKAWA Hitoshi
Chugai Research Institute for Medical Science, Inc.
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KATSUYAMA Kiyoka
Chugai Research Institute for Medical Science, Inc.
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HAYASHI Shuji
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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KATO Atsuhiko
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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SUZUKI Masami
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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Kato Atsuhiko
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Yamazaki Masaki
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Hayashi Shuji
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Ito Tsuneo
Chugai Research Institute For Medical Science Inc.
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足立 健児
Safety Assessment Department Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Adachi Kenji
Department Of Dermatology Showa University Fujigaoka Hospital
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Miyoshi Akio
Safety Assessment Department Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Miyoshi Akio
Department Of Molecular Science And Technology Faculty Of Engineering Doshisha University
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鈴木 雅実
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Hayashi Shuji
Department Of Neurosurgery Fukuoka University Faculty Of Medicine
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Takai Hirotake
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Adachi Kenji
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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Arakawa Hitoshi
Chugai Research Institute For Medical Science Inc.
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Katsuyama Kiyoka
Chugai Research Institute For Medical Science Inc.
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Suzuki Masami
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Ito Tsuneo
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Kato Atsuhiko
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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三沢 保幸
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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FUJII Etsuko
PharmaLogicals Research Pte. Ltd.
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Katagiri Kouichi
Chugai Research Institute For Medical Science Inc
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三沢 保幸
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Misawa Yasuyuki
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Kato Atsuhiko
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Adachi Kenji
Department Of Agricultural Chemistry Yamagata University:(present Office)central Laboratory Rengo Co
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Suzuki Masami
Department Of Metallurgy
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Suzuki Masami
Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University
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SUZUKI Masami
Department of Agricultural Chemistry, Gifu University
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Hayashi Shuji
Department of Cardiovascular Medicine, Tokushima University Hospital, Japan
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