The Initial Lesions Caused by Sodium Chloride in Canine Gastric Mucosa
スポンサーリンク
概要
- 論文の詳細を見る
Etiologic research has shown that sodium chloride contributes to gastric carcinogenecity. We investigated the initial changes of gastric mucosa in the cytoplasmic mucin of superficial epithelium and the surface mucous layer of Beagle dogs after an oral dose of sodium chloride. Animals were sacrificed at 0.5, 1.5, 3.5 and 5.5 hours after dosing with 5 g of sodium chloride filled gelatin capsules. Sodium chloride caused lesions such as degeneration and detachment of epithelium, and erosion of mucosa as early as 0.5 hours after administration. ConA type III mucin, the evidence for the origin from gland mucous cells, increased after treatment and was found to be thick at the area of the lesion with progression of decreased mucin in the surface mucous layer, or where epithelial detachment occurred. Gland mucous cell mucin might be responsible for the protection and healing of gastric epithelium. Sulfomucin, demonstrated by high iron diamine staining, originally in the lower foveolar cells of the gastric pits was widely observed in the superficial epithelium of the luminar surface during the time course of the study. PCNA positive generative cells originally in the ithmus and parietal cells originally below the gastric pits were also found among superficial epithelial cells of the luminar surface. It was suggested that these cells might cover the lesion as well as superficial epithelium next to the detaching part.
- 日本毒性病理学会の論文
- 1998-03-01
著者
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Chiba Shuichi
Safety Assessment Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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Yamazaki Masaki
中外製薬富士御殿場研究所
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Kato Atsuhiko
中外製薬富士御殿場研究所
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Kato Atsuhiko
Safety Assessment Department, Chugai Pharmaceutical Co. Ltd.
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Sugimoto Tetsuro
Safety Assessment Department, Chugai Pharmaceutical Co. Ltd.
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杉本 哲朗
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Sugimoto Tetsuro
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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Kato Atsuhiko
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Sakurai Takayuki
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Yamazaki Masaki
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Sakurai Takayuki
Safety Assessment Department Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd.
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Ito Tsuneo
Chugai Research Institute For Medical Science Inc.
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Chiba Shuichi
Safety Assessment Dep. Fuji Gotemba Res. Laboratories Chugai Pharmaceutical Co. Ltd.
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Chiba Shuichi
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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三沢 保幸
Safety Assessment Department Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd.
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ITO Tsuneo
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd.
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NIKI Rikio
SLA Research, Inc.
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Sugimoto Tetsuro
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Niki Rikio
Sla Research Inc.
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Ito Tsuneo
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Kato Atsuhiko
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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三沢 保幸
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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三沢 保幸
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Misawa Yasuyuki
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Kato Atsuhiko
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Sugimoto Tetsuro
Safety Assessment Department Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd.
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