THE EFFECT OF FOOD DYE AND OTHER ENVIRONMENTAL SUBSTANCES ON THE HOST DEFENSE REACTION IN MICE IN RELATION TO VIRUS INFECTION

スポンサーリンク

概要

• 論文の詳細を見る

• Environmental substances were examined for their effect on interferon induction and delayed type hypersensitivity (DTH) responses in mice. Amaranth, safrole, phenacetin and nicotine suppressed the DTH response, and suppressed the serum interferon titers induced by virus infection. However, they did not affect the interferon titers which were induced by tilorone, a chemical inducer. The peak of interferon titer was 12 hours after infection with herpes simplex virus type 2 (HSV-2). Therefore, amaranth, safrole, phenacetin and nicotine were given to mice intraperitoneally 24 hours before, and 2 and 18 hours after infection with HSV-2. It was found that safrole and nicotine shortened the mean survival time of HSV-2 infected mice when they were given to mice 2 hours after virus inoculation. Amaranth and phenacetin showed similar effects. However it was not definite statistically. In biochemical and hematological tests, these four substances did not affect the functions of liver, kidney and carbohydrate metabolism in normal mice. These results suggest that substances which may often be taken into the body have the potential to affect the onset of virus infectious diseases as a result of the suppression of the host defense reaction.

• 日本トキシコロジー学会の論文
• 1986-08-25

著者

• FUKUSHIMA Koji

  Division of Gastroenterology, Tohoku University Graduate School of Medicine

• Sakurai Takayuki

  中外製薬安全性研究所

• Sakurai Takayuki

  Safety Assessment Department Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd.

• Fukushima K

  Keio Univ. Tokyo Jpn

• FUKUMA Mariko

  Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University

• SETO Yoshiko

  Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University

• SAKURAI Toshiharu

  Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University

• DAN Katsuaki

  Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University

• FUJITA Haruhisa

  Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University

• TOYOSHIMA Shigeshi

  Division of Chemotherapy, Pharmaceutical Institute, School of Medicine, Keio University

• Fukushima Koji

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

• Toyoshima Shigeshi

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

• Dan Katsuaki

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

• Seto Yoshiko

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

• Fukuma Mariko

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

• Sakurai Toshiharu

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

• Sakurai Toshiharu

  Division Of Cellular Signaling Institute For Advanced Medical Research Keio University School Of Med

• Fujita Haruhisa

  Division Of Chemotherapy Pharmaceutical Institute School Of Medicine Keio University

関連論文

• A novel third generation bisphosphonate, minodronate (YM529), prevented proliferation and migration of hepatocellular carcinoma cells through inhibition of mevalonate pathway
• Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan
• Transient elastography for measurement of liver stiffness measurement can detect early significant hepatic fibrosis in Japanese patients with viral and nonviral liver diseases
• A case of HIV co-infected with hepatitis B virus precore/core deletion mutant treated by entecavir
• Living Related Liver Transplantation for Acute Fulminant Hepatitis B : Experience from Two Possible Hyper-Acute Cases
• Lack of common mutation in the alfa-subunit of the mitochondrial trifunctional protein and the polymorphism of CYP2E1 in three Japanese women with acute fatty liver of pregnancy/HELLP syndrome
• New measurement method of tissue factor (TF) activity in whole blood of cynomolgus monkeys (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Application of coagulation and fibrinolytic tests for humans to cynomolgus monkeys.(GENERAL SESSION BY POSTER PRESENTATION)(BLOOD SYSTEM AND HEMATOLOGY)
• P-88 Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats : Testicular toxicity of 2-or 4-week repeated or single-dose administration of a novel Platinum Complex(Proceedings of the 27th Annual Meeting)
• COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 11)TESTICULAR TOXICITY OF 2-OR 4-WEEK REPEATED OR SINGLE-DOSE ADMINISTRATION OF A NOVEL PLATINUM COMPLEX
• 3B-08 Changes in Serum C-Reactive Protein (CRP) in Experimental Gastropathy
• Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinoma
• Nuclearity and BrdU Labeling of Rat Hepatocytes in Cytocentrifuge Preparations of Freshly Isolated Hepatocytes with Cumulative Labeling of Bromodeoxyuridine
• PROLONGATION OF PT AND APTT UNDER EXCESSIVE ANTICOAGULANT IN PLASMA FROM RATS AND DOGS
• Immunohistochemical Identification of T- and B-Lymphocytes in Formalin-Fixed, Paraffin-Embedded Rat Sections
• HISTOPATHOLOGICAL STUDY OF THE EFFECTS OF A SINGLE INTRATRACHEAL INSTILLATION OF SURFACE ACTIVE AGENTS ON LUNG IN RATS
• A case of severe recurrent hepatitis with common variable immunodeficiency
• The High Incidence of the Emergence of Entecavir-Resistant Mutants among Patients Infected with Lamivudine-Resistant Hepatitis B Virus
• Bioinformatic approach for cholangiocyte pathophysiology
• Amniotic epithelial cell-derived cholangiocytes in experimental cholestatic ductal hyperplasia
• Mapping of a disease susceptibility locus in the HLA region for Primary Biliary Cirrhosis in Japan
• Sustained Clinical Improvement of a Patient with Decompensated Hepatitis B Virus-Related Cirrhosis after Treatment with Lamivudine Monotherapy
• Differential expressions of aquaporin proteins in human cholestatic liver diseases
• THE EFFECT OF FOOD DYE AND OTHER ENVIRONMENTAL SUBSTANCES ON THE HOST DEFENSE REACTION IN MICE IN RELATION TO VIRUS INFECTION
• Lens culinaris agglutinin-A-reactive alpha-fetoprotein as a marker for liver atrophy in fulminant hepatic failure
• Correlation between p21^ and p16^ expression in hepatocellular carcinoma
• Changes in serum α1-acid glycoprotein and interleukin-8 in experimental lung injury in rats
• The Initial Lesions Caused by Sodium Chloride in Canine Gastric Mucosa
• ON ANTITUMOR AMINO ACID DERIVATIVE WHICH DO NOT SHOW ADVERSE EFFECTS ON HEMATOPOIETIC ORGANS THROUGH IT DISTRIBUTED INTO THEM (The Fourth Meeting for the Study of Toxic Effect)
• Identification of human tumor antigens and its implications for diagnosis and treatment of cancer
• Relation between Stable Glycated Hemoglobin A_ and Plasma Glucose Levels in Diabetes-model Mice
• Characterization of Insulin-Dependent Diabetes Mellitus Induced by a New Variant (DK-27) of Encephalomyocarditis Virus in DBA/2 Mice
• Treatment of Primary Biliary Cirrhosis : A new challenge?
• Characterization of the epithelial cell adhesion molecule (EpCAM)^+ cell population in hepatocellular carcinoma cell lines
• DISTRIBUTION OF ^C-A-145-AN ANTITUMOR AMINO ACID DERIVATIVE-IN MICE (The Fourth Meeting for the Study of Toxic Effect)
• The Nutritional Index 'CONUT' Is Useful for Predicting Long-Term Prognosis of Patients with End-Stage Liver Diseases
• Lymphotropic HCV strain can infect human primary naive CD4^+ cells and affect their proliferation and IFN-γ secretion activity
• ENHANCEMENT OF NEURAMINIDASE ACTIVITY WITH INFLUENZA VIRUS BY ANTI-INFLUENZA VIRUS DRUG
• Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT
• ANTIVIRIN, A NEW VIRAL INHIBITORY FACTOR PRODUCED FROM CELLS CULTURED IN THE ABSENCE OF VIRAL INFECTION

もっと見る 閉じる

スポンサーリンク