PROLONGATION OF PT AND APTT UNDER EXCESSIVE ANTICOAGULANT IN PLASMA FROM RATS AND DOGS
スポンサーリンク
概要
- 論文の詳細を見る
Prothrombin time (PT) and activated partial thromboplastin time (APTT) were studied under excessive sodium citrate using the plasma from rats and beagle dogs. Addition of sodium citrate into the plasma caused a prolongation of PT and APTT. The prolongation was dependent on the concentration of sodium citrate or calculated hematocrit. The degree of prolongation was more severe in rats than in dogs, and in APTT than in PT. These results suggest that an artificial prolongation of PT and APTT occurs under excessive sodium citrate (e.g., elevated hematocrit), and that the degree differs between species and between parameters.
- 日本トキシコロジー学会の論文
- 1998-05-09
著者
-
Noguchi Noriko
中外製薬
-
Noguchi Noriko
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
-
Noguchi Noriko
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
-
Noguchi Noriko
Toxicol.res.labs. Chugai Pharmaceu.co. Ltd.
-
Noguchi Noriko
東京大学先端科学技術研究センター
-
Sugimoto Tetsuro
Safety Assessment Department, Chugai Pharmaceutical Co. Ltd.
-
杉本 哲朗
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
Sugimoto Tetsuro
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
-
Sugimoto Tetsuro
Fuji Gotemba Laboratories Chugai Pharmaceutical Co. Ltd.
-
Sakurai Takayuki
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
-
HASEGAWA TAEKO
Safety Assessment Department, Chugai Pharmaceutical Co., Ltd.
-
Hasegawa Taeko
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
-
Tanaka K
Institute Of Earth And Space Science Graduate School Of Science Osaka University
-
KURATA Masaaki
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd.
-
KASUGA Yoshitomo
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd.
-
TANAKA Kouichi
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd.
-
HASEGAWA Takashi
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd.
-
Sakurai Takayuki
Safety Assessment Department Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd.
-
田中 宏治
Med.safe.res.labs. Sankyo Co. Ltd. Of Shizuoka Pref.
-
Kurata Masaaki
ファイザー製薬中央研究所 安全性研究統括部
-
Kurata Masaaki
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
-
Tanaka K
Department Of Toxicology Graduate School Of Pharmaceutical Sciences Osaka University:(present Office
-
Tanaka Keiichi
Dep. Toxicol. Grad. School Pharmaceut. Sci. Osaka Univ.
-
Sugimoto Tetsuro
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
-
Kasuga Yoshitomo
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
-
Kojitani Takatoshi
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
-
Sugimoto Tetsuro
Safety Assessment Department Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd.
-
Kurata Masaaki
Drug Safety Research And Development Nagoya Laboratories Pfizer Global Research And Development Pfiz
-
Hasegawa Takashi
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
関連論文
- Differences in bone responses to recombinant human granulocyte colony-stimulating factor between mice and rats
- Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys
- CHARACTERIZATION OF RESISTANCE TO BROMOBENZENE-INDUCED HEPATOTOXICITY BY MICROARRAY
- RESISTANCE TO THE SKELETAL MUSCLE INJURY EXPRESSED BY REPEATED TREATMENT WITH COMPOUND A THAT HAS HMG-CoA REDUCTASE INHIBITORY ACTIVITY
- P7-41 Skeletal muscle injury caused by compound A completely recovers in spite of further treatment?(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE (S,R)-SULFOXIMINE
- Involvement of Drug Transporters in the Acquired Resistance to Bromobenzene-induced Hepatotoxicity (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 21C-04-2 Correlation between Localization of CYP1A1/2 and Aryl Hydrocarbon Receptor in the Liver Lobule of Rats Treated with 3-methylcholantherene(3MC) or β-Naphthoflavone (BNF).
- Effects of Growth Hormone on Bone in Mini Rats
- Comparison of Bone Changes between Neonatally Monosodium Glutamate-Treated Rats and Mini Rats
- Effects of phenobarbital, a drug-metabolizing enzymes inducer, on hepatic DNA ploidy in hepatectomized rats
- Effect of Glucose Feeding on Regenerating Rat Liver Following Partial Hepatectomy
- 2C-19 The increase in unirary oxcretion of 6 β-hydroxycortisol in common marmosets as a marker of hepatic CYP3A induction
- "P-36 Hepatic response to continuous cytochrome P450 inhibition in rats sequentially treated with α-hederin.
- Relationship of induction of phase II enzymes to decrease in gap-junctional intercellular communication in rat liver treated with a disinfectant, Etridiazole.
- Correlation between decrease in intercellular communication and phase I enzyme induction in rat liver treated with phenobarbital : an examination of the reversibility during PB-withdrawal.
- DOES GLUCOSE FEEDING POTENTIATE THE TOXICITY OF HEPATOTOXICANTS?
- Gene Expression Induced by BO-653, Probucol and BHQ in Human Endothelial Cells
- Analysis by lectin histochemistry of kidney in Gottingen origin miniature pigs(Kidney, Urinary system, Proceedings of the 32nd Annual Meeting)
- Immunohistochemical detection of PTHrP and PTH/PTHrP receptor 1 on the odontoblastic reparative process after actinomycin D treatment in rats(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- A Decalcifying and Paraffin-embedding Method for Enzyme Histochemical and Immunohistochemical Studies of Bone(Proceedings of the 32nd Annual Meeting)
- COMBINATION OF FIXATION USING PLP FIXATIVE AND EMBEDDING IN PARAFFIN BY THE AMeX METHOD IS USEFUL FOR HISTOCHEMICAL STUDIES IN ASSESSMENT OF IMMUNOTOXICITY
- P12-11 The Combination of Fixation Using PLP Fixative and Embedding in Paraffin by the AMeX Method is Useful for Histopathological Studies in Assessment of Immunotoxicity.
- Histopathological Characteristics of Calcified Lesions of the Aortic Orifice (Ostium Aortae) in Dogs
- Application of Flash and Cumulative Labeling with Bromodeoxyuridine for Analysis of Cell Kinetics of Bone Cells and Chondrocytes in Young Growing Rats
- Acquired Resistance to Bromobenzene Hepatotoxicity by Repeated Treatment of Rats with Bromobenzene
- New measurement method of tissue factor (TF) activity in whole blood of cynomolgus monkeys (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Application of coagulation and fibrinolytic tests for humans to cynomolgus monkeys.(GENERAL SESSION BY POSTER PRESENTATION)(BLOOD SYSTEM AND HEMATOLOGY)
- P-88 Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats : Testicular toxicity of 2-or 4-week repeated or single-dose administration of a novel Platinum Complex(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 11)TESTICULAR TOXICITY OF 2-OR 4-WEEK REPEATED OR SINGLE-DOSE ADMINISTRATION OF A NOVEL PLATINUM COMPLEX
- CONTRIBUTION OF INTESTINAL CALCIUM ABSORPTION TO 1,25-DIHYDROXYVITAMIN D_3-INDUCED CALCIUM ACTION IN THE TOTAL PARENTERAL NUTRITION RAT
- TOTAL PARENTERAL NUTRITION USING CONTINUOUS INTRAVENOUS INFUSION VIA THE POSTERIOR VENA CAVA IN RATS
- Changes of 1, 25 (OH)_2D_3-induced calcium action in the total parenteral nutrition feeding rat (examination of dose-dependent action)(General toxicity, Proceedings of the 32nd Annual Meeting)
- P7-40 Changes of 1,25(OH)_2D_3-induced calcium action in the rat total parenteral nutrition model(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O12-07 Time Course Changes of Sorbitol Dehydrogenase. Glutamate Dehydrogenase, 5'-Nucleotidase and Total Serum Bile Acids During Acute Liver Injury in Rat
- 3B-08 Changes in Serum C-Reactive Protein (CRP) in Experimental Gastropathy
- Nuclearity and BrdU Labeling of Rat Hepatocytes in Cytocentrifuge Preparations of Freshly Isolated Hepatocytes with Cumulative Labeling of Bromodeoxyuridine
- CELLULAR SIZE OF BONE MARROW CELLS FROM RATS AND BEAGLE DOGS
- PROLONGATION OF PT AND APTT UNDER EXCESSIVE ANTICOAGULANT IN PLASMA FROM RATS AND DOGS
- 3B-04 Effect of Blood Collection Imitating Toxicokinetic Study on Rat Hematological Parameters
- 3B-02 Significance of Cellular Size Mcasurement in Differentiation of Bone Marrow Cells.
- EFFECT OF BLOOD COLLECTION IMITATING TOXICOKINETIC STUDY ON RAT HEMATOLOGICAL PARAMETERS
- Development of a Novel Model for Streptozotocin-induced Renal Cell Tumors and Chronic Diabetes in Gottingen Minipigs
- Lobular Difference in Fibrotic Changes in Rat Cirrhosis Model Induced by Carbon Tetrachloride
- PLP-AMeX Method, Fixation Using PLP Fixative and Embedding in Paraffin by the AMeX Method, is Useful not only for Histochemistry but also In Situ Hybridization
- Recovery of blood and urine Ca and IP level after low phosphorus state.(GENERAL SESSION BY POSTER PRESENTATION)(LABORATORY ANIMAL TECHNIQUES)
- Immunohistochemical Identification of T- and B-Lymphocytes in Formalin-Fixed, Paraffin-Embedded Rat Sections
- Metal Response Element-binding Transcription Factor-1 Is Activated by Degradation of Metallothionein
- Immunohistochemical Detection of PTHrP and PTH/PTHrP Receptor 1 on the Odontoblastic Reparative Process after Actinomycin D Treatment in Rats
- 3A-18 Effect of methotrexate on ileal 5-hydroxy-tryptamine contents in ferrets
- アカゲザルのリンパ球サブセット解析におけるリンパ球分離法の比較検討
- Toxicity Screening Strategy in Early Stage Drug Development : Current Situation and Perspective(Toxicity Screening Strategy in Early Stage Drug Development : Current Situation and Perspective, Proceedings of the 32nd Annual Meeting)
- HISTOPATHOLOGICAL STUDY OF THE EFFECTS OF A SINGLE INTRATRACHEAL INSTILLATION OF SURFACE ACTIVE AGENTS ON LUNG IN RATS
- Expression of bone marrow stromal cell specific antigen during murine development : Its expression in embryonic hematopoietic tissues as well as in other developing tissues
- O-04 Low NO production in metallothionein-null macrophages in response to endotoxin stimulation(BLOOD, IMMUNE AND ALLERGIC SYSTEM)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Physiological Role of Endogenous Metallothionein in the Immune System(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Mechanism of a Terahertz Optical Kerr Shutter with a Gold Nanoparticle System
- Spectrally-Resolved Four-Wave Mixing Spectroscopy in the Exciton and Biexciton Resonant Region in PbI_2
- Two Metallothioneins in the Fresh-Water Fish, Crucian Carp(Carassius cuvieri) : cDNA Cloning and Assignment of Their Expression Isoforms
- Effect of Metallothionein on Doxorubicin-induced Hepatotoxicity(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Physiological Role of Ascorbic Acid Secretion System in the Stomach (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- 3C-06 Hepatoprotection by zinc and sakuraso-saponin in metallothionein-deficient mice
- 3C-05 Molecular Mechanism of Activation of Mouse Metallothionein-I Promoter by Interleukin-6 and Glucocorticoid
- BINDING OF Cd TO METALLOTHIONEIN IN THE PLACENTA OF Cd-TREATED MOUSE
- P10-15 The Skeletal Muscle Injury Induced by Sodium Pivalate Is Reversible?
- Production of Normal ↔ Macular Mouse Chimeras: The Presence of Critical Tissue in the Macular Mutant Mouse, a Model of Menkes' kinky Hair Disease
- EVALUATION FOR A POSSIBILITY OF PERIPHERAL NERVE PARALYSIS CAUSED BY INJECTION OF DRUGS : ACETIC ACID EXPOSURE AROUND THE SCIATIC NERVE IN RATS
- EFFECTS OF LYSINE-INDUCED ACUTE RENAL FAILURE IN DOGS
- Application of the continuous intravenous infusion to total parenteral nutrition in rats.(GENERAL SESSION BY POSTER PRESENTATION)(LABORATORY ANIMAL TECHNIQUES)
- P11-07 Changes of non-protein nitrogen and blood urea nitrogen as renal failure parameters by the amino acid toad
- Emission from the Higher Members of Exciton (n = 2,3 and 4) in β-ZnP_2
- The basic examination of urinary protein fractions using SDS-PAGE in cynomolgus monkeys.(GENERAL SESSION BY POSTER PRESENTATION)(KIDNEYS AND URINARY EXCRETION SYSTEM)
- P-3 Time-Course Changes of Canine Serum Sorbitol Dehydrogenase, Glutamil Acid Dehydrogenase, 5'-Nucleaotidase and Total Bile Acid During Acute Liver lnjury after Carbon Tetrachloride Administration(Proceedings of the 27th Annual Meeting)
- Development of New Safety Tests for Environmental Chemicals at Low Contaminant Levels (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- 415 Rat β_2-microglobulin (β2-m) : Development and application of enzymeimmunoassay (EIA) for detection of drug-induced nephrotoxicity
- de Haas-van Alphen Studies of YbAs above and below Neel Temperature
- Magnetic Alignment at Reduced Field Intensity Due to Decrease of Temperature Observed for Nonferromagnetic Particles Possessing Paramagnetic and Diamagnetic Anisotropy
- Magnetic Alignment of Micron-Sized Particles at Low Temperature Achieved on Particles Dispersed in He Gas Medium
- Characteristics of Paramagnetic and Diamagnetic Anisotropy which Induce Magnetic Alignment of Micron-Sized Non-Ferromagnetic Particles
- Stabilization of the Position of a Solid Body Isolated in Micro-Gravity and Field-Induced Rotational-Oscillation Caused by Diamagnetic Anisotropy
- Protective Effect of Zinc against Lipopolysaccharide/D-Galactosamine-Induced Lethality
- Metallothionein-Null Mice Are Sensitive to Endotoxine/D-Galactosamine-Induced Hepatotoxicity
- 22C-10-4 Lipopolysaccharide-Induced Lethality in D-Galactosamine-Sensitized Metallothionein-Null Mice.
- Role of Myeloperoxidase in the Neutrophil-Induced Oxidation of Low Density Lipoprotein as Studied by Myeloperoxidase-Knockout Mouse
- INVESTIGATION OF THE MECHANISM OF DRUG-INDUCED AUTOIMMUNE HEMOLYTIC ANEMIA IN CYNOMOLGUS MONKEYS ELICITED BY A REPEATED-DOSE OF A HUMANIZED MONOCLONAL ANTIBODY DRUG
- Changes in serum α1-acid glycoprotein and interleukin-8 in experimental lung injury in rats
- The Initial Lesions Caused by Sodium Chloride in Canine Gastric Mucosa
- Participation of Intestinal Metallothionein in Absorption and Distribution of Orally Administered Cadmium (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- A New Mass-Enhanced Ferromagnet: U_2PtSi_3
- Photogenerated Carriers in SrTiO_3 Probed by Mid-Infrared Absorption(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Ewing 肉腫における神経分化能
- COMPARISON BETWEEN DENSITY GRADIENT CENTRIFUGAL METHOD AND WHOLE BLOOD METHOD FOR LYMPHOCYTE SURFACE MARKER ANALYSIS WITH FLOW-CYTOMETRY IN RHESUS MONKEYS
- EFFECTS OF 1α, 25-DIHYDROXYVITAMIN D3 ON CYTOKERATIN PATTERN AND CELL KINETICS IN RAT EPIDERMIS
- STANDARDIZATION OF DENSITY GRADIENT CENTRIFUGAL METHOD FOR LYMPHOCYTE SURFACE MARKER ANALYSIS WITH FLOW-CYTOMETRY IN CYNOMOLGUS MONKEYS.
- 210 USE OF BROMODEOXYURIDINE FOR INVESTIGATING CHEMICAL-INDUCED MYELOTOXICITY
- 417 AGE-RELATED AND SEX DIFFERENCES IN MYELOTOXICITY STUDY USING RATS
- The Combination of Fixation Using PLP Fixative and Embedding in Paraffin by the AMeX Method is Useful for Immunohistochemical and Enzyme Histochemical Studies of the Lung
- Endometriosis in a Rhesus Monkey
- Effects of Granulocyte Colony-Stimulating Factor on the Development of Inflammation in Bleomycin-Induced Lung Injury
- W2-3 USE OF PRIMARY CULTURED HEPATOCYTES FOR TOXICOLOGY