CONTRIBUTION OF INTESTINAL CALCIUM ABSORPTION TO 1,25-DIHYDROXYVITAMIN D_3-INDUCED CALCIUM ACTION IN THE TOTAL PARENTERAL NUTRITION RAT
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概要
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To investigate the contribution of intestinal calcium (Ca) absorption to 1,25-dihydrox-yvitamin D_3 (1,25(OH)_2D_3)-induced Ca action, we assessed parameters related to Ca metabolism after a single dosing of 1,25(OH)_2D_3 in the total parenteral nutrition (TPN) solution or 5% D-mannitol (MAN) solution treatment with rats. Animals were divided into 6 groups (vehicle, 100 μg/kg p.o. and 25 μg/kg i.v.; n=8) in Experiment 1 and 8 groups (vehicle, 1, 10 and 100 μg/kg p.o.; n=6) in Experiment 2 at TPN or MAN solution treatment. In both experiments, the parameters related to Ca metabolisms, urinary Ca and urinary deoxypyridinoline on 0-24 hr or serum Ca, osteocalcin and parathyroid hormone at 24 hr were measured after 1,25(OH)_2D_3 dosing. 1,25(OH)_2D_3-related increased urinary Ca or serum Ca were observed in both experiments. Decrease rates in change of urinary Ca in TPN solution treatment rats were 36.3% (100 μg/kg p.o.) or 47.1% (25 μg/kg i.v.) of MAN solution treatment rats in Experiment 1, and 29.0% (1 μg/kg), 56.2% (10 μg/kg) or 35.3% (100 μg/kg) of MAN solution treatment rats in Experiment 2. Decrease rates in change of serum Ca at 72 hr in TPN solution treatment rats were 57.3% (100 μg/kg p.o.) or 44.5% (25 μg/kg i.v.) of MAN solution treatment rats in Experiment 1, and were 57.0% (100 μg/kg) of MAN solution treatment rats in Experiment 2. There were no differences in the change of serum Ca in the 1,25(OH)_2D_3 1 or 10-μg/kg group in Experiment 2. Our results suggest that differences in urinary Ca or serum Ca between MAN solution treatment rats and TPN solution treatment rats express the contribution of intestinal Ca absorption to 1,25(OH)_2D_3-induced Ca action in the conditions of the study.
- 日本トキシコロジー学会の論文
- 2006-10-23
著者
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Chiba Shuichi
Safety Assessment Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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杉本 哲朗
Fuji Gotemba Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Sakurai Takayuki
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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ASANUMA Kentaro
Safety Assessment Department, Chugai Pharmaceutical Co., Ltd.
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KOMATSU Shun-ichiro
Safety Assessment Department, Chugai Pharmaceutical Co., Ltd.
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TAKAI Ryo
Safety Assessment Department, Chugai Pharmaceutical Co., Ltd.
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Chiba Shuichi
Safety Assessment Dep. Fuji Gotemba Res. Laboratories Chugai Pharmaceutical Co. Ltd.
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Asanuma Kentaro
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Takai Ryo
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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Sugimoto Tetsuro
Safety Assessment Laboratory Chugai Pharmaceutical Co. Ltd.
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Komatsu Shun-ichiro
Safety Assessment Department Chugai Pharmaceutical Co. Ltd.
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