BINDING OF Cd TO METALLOTHIONEIN IN THE PLACENTA OF Cd-TREATED MOUSE
スポンサーリンク
概要
- 論文の詳細を見る
The toxicological significance of the placental metallothionein (MT) was studied from the viewpoint of cadmium (Cd) intoxication. The Cd concentration was higher in the placenta than the kidneys until 8 hr after a single injection of ^<109>CdCl_2, but was very low after administration of ^<109>Cd-MT. Compared with lower doses, fetal Cd began to increase at the dose of 2 mg/kg. Alkaline phosphatase activity in the placenta was significantly decreased, and dead fetuses appeared at this dose. The MT concentration was not increased by the Cd injection but the ratio of Cd/Zn in MT increased proportionally to the dose up to 2 mg/kg. MT was detected in the placenta during all stages of pregnancy, and its concentration was higher in the earlier stage. The metal bound to MT was mainly Zn, and very little Cu was bound. In the mice that became pregnant after ^<109>Cd accumulation, redistribution of ^<109>Cd was not observed. MT-I and -II in the placenta were identified by column chromatography and immuno-blotting methods. These findings suggest that the placental MT might play a protective role against Cd toxicity by trapping of the metal.
- 日本トキシコロジー学会の論文
著者
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Itoh N
Department Of Toxicology Graduate School Of Pharmaceutical Sciences Osaka University
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Kawai Y
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Kawai Yuichi
Graduate School Of Pharmaceutical Sciences Kobe-gakuin Univ.
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Kawai Yuichi
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Nabeshi Hiromi
Lab. Of Pharmaceutical Proteomics National Inst. Of Biomedical Innovation (nibio)
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MAYUMI Tadanori
Faculty and Graduate School of Pharmaceutical Sciences, Osaka University
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Tanaka K
Institute Of Earth And Space Science Graduate School Of Science Osaka University
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Kawai Yuichi
Faculty Of Pharmaceutical Sciences Kobe-gakuin University:faculty Of Pharmaceutical Sciences Osaka U
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Fujita Y
Univ. Shizuoka Shizuoka Jpn
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Fujita Yuki
Faculty Of Engineering Kanagawa University
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田中 宏治
Med.safe.res.labs. Sankyo Co. Ltd. Of Shizuoka Pref.
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Tanaka K
Department Of Toxicology Graduate School Of Pharmaceutical Sciences Osaka University:(present Office
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Muto Norio
Faculty Of Life And Environmental Sciences Prefectural University Of Hiroshima
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Itoh Norio
Dep. Toxicol. Grad. School Pharmaceut. Sci. Osaka Univ.
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ITOH Norio
Faculty of Pharmaceutical Sciences, Osaka University
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TANAKA Keiichi
Faculty of Pharmaceutical Sciences, Osaka University
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NAKANISHI Hirokuni
Faculty of Pharmaceutical Sciences, Osaka University
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HWANG Gab
Faculty of Pharmaceutical Sciences, Osaka University
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MIN Kyon-son
Faculty of Nutrition, Kobe-Gakuin University
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ONOSAKA Satomi
Faculty of Nutrition, Kobe-Gakuin University
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Kawai Y
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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Kawai Yuichi
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Hwang Gab
Department Of Toxicology Graduate School Of Pharmaceutical Sciences Osaka University
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Tanaka Keiichi
Dep. Toxicol. Grad. School Pharmaceut. Sci. Osaka Univ.
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Muto Norio
Faculty Of Life And Environmental Science Prefectural University Of Hiroshima
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Min K‐s
Kobe Gakuin Univ. Kobe
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Min Kyong-son
Faculty Of Nutrition Kobe Gakuin University
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Onosaka S
Kobe Gakuin Univ. Kobe
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Onosaka Satomi
Faculty Of Nutrition Kobe Gakuin University
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Kojitani Takatoshi
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
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Nabeshi Hiromi
Department Of Toxicology And Safety Science Graduate School Of Pharmaceutical Sciences Osaka Univers
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Tanaka Keiichi
Faculty Of Nutrition Kobe-gakuin University
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TANAKA Keiichi
Faculty of Agriculture, Gifu University
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