Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46

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概要

• 論文の詳細を見る

• Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1). One approach to prevent the onset of ATL is to inhibit the growth/transmission of HTLV-1 infected cells using arsenic trioxide (As2O3). However, there are no reports on the transmission inhibitory effect of As2O3. In this study, we reveal that As2O3 exerts an inhibitory effect on syncytium formation between HTLV-1 infected MT-2 and HeLa cells. In addition, Western blot analysis revealed that the HTLV-1 derived envelope protein gp46 was down regulated by As2O3 treatment, suggesting that As2O3 may inhibit HTLV-1 virus transmission via down-regulation of gp46. These results suggest that As2O3 may be a promising drug to treat refractory HTLV-1-related diseases.

• 日本薬学会の論文

著者

• Nagano Kazuya

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Abe Yasuhiro

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Kamada Haruhiko

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Kiwada Hiroshi

  徳島大学 ヘルスバイオサイエンス研究部薬物動態制御学

• Kiwada Hiroshi

  Faculty Of Pharmaceutifal Sciences The University Of Tokushima

• SHIBATA Hiroko

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• NOMURA Tetsuya

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• SUGITA Toshiki

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• TSUTSUMI Yasuo

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• TSUNODA Shin-ichi

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• YOSHIOKA Yasuo

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Shibata Hiroko

  Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)

• Higashisaka Kazuma

  Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.

• Kamada Haruhiko

  医薬基盤研究所 創薬プロテオミクスプロジェクト

• Kamada Haruhiko

  Laboratory Of Pharmaceutical Proteomics (lpp) National Institute Of Biomedical Innovation (nibio)

• Kiwada Hiroshi

  Department Of Pharmacokinetics And Biopharmaceutics Faculty Of Pharmaceutical Sciences The Universit

• Nabeshi Hiromi

  Lab. Of Pharmaceutical Proteomics National Inst. Of Biomedical Innovation (nibio)

• Kamiya Hiroyuki

  Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.

• Nabeshi Hiromi

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Yoshikawa Tomoaki

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Minowa Kyoko

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Yamashita Takuya

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Itoh Norio

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Kiwada H

  Faculty Of Pharmaceutifal Sciences The University Of Tokushima

• Kiwada Hiroshi

  Department Of Pharmacokinetics And Biopharmaceutics Subdivision Of Biopharmaceutical Science Institu

• Yoshikawa Tomoaki

  Department Of Toxicology And Safety Science Graduate School Of Pharmaceutical Sciences Osaka Univers

• Yoshioka Yasuo

  Laboratory Of Biopharamceutical Research National Institute Of Biomedical Innovation

• Nabeshi Hiromi

  Department Of Toxicology And Safety Science Graduate School Of Pharmaceutical Sciences Osaka Univers

• Kamada Haruhiko

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Abe Yasuhiro

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Sugita Toshiki

  Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation (NiBio)

• Nagano Kazuya

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

• Yoshioka Yasuo

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation

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