Hypolipcmic Effect of Cyclocarya paliurus (Batal) Iljinskaja in Lipid-Loaded Mice
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概要
- 論文の詳細を見る
We investigated the inhibitory effect of Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus) extract on postprandial hyperlipemia in mice. A single oral administration of C. paliurus extract (250 mg/kg) suppressed an increase in plasma triacylgycerol (TG) levels when fed with 5 ml/kg of lard and olive oil. The inhibition rates were 28. 6% and 24. 1%, respectively, but free fatty acid (FFA) levels in plasma were not significantly affected as compared with control group mice. In addition, C. paliurus extract showed inhibitory activity toward pancreatic lipase, a key enzyme of dietary TG absorption, with an IC_50 of 9. 1 μg/ml in vitro. Our results suggested that thehypolipemic action of C. paliurus extract was probably interrelated with suppression of the activity of digestive lipase, and as a result, the blood lipid level was reduced.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
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Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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SHIBATA Hiroshi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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深見 治一
Institute For Biomedical Research Research Center Suntory Ltd.
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深見 治一
サントリー(株)基礎研
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KURIHARA Hiroshi
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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Tanaka Tetsuro
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tanaka T
Institute For Health Care Science Suntory Ltd.
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Tanaka Takaharu
Institute For Health Care Science Suntory Ltd.
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Tanaka T
Suntory Consumer Health Products Division
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Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kawanishi Hideaki
Institute For Health Care Science Suntory Ltd.
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Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
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ASAMI Sumio
Institute for Health Care Science, Suntory Ltd.
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Fukami Harukazu
Institute for Health Care Science, Technological Development Center, Suntory Ltd.
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Asami S
Institute For Health Care Science Suntory Ltd.
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Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
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Fukami Harukazu
Dep. Of Bioscience And Biotechnology Fac. Of Bioenvironmental Sci. Kyotogakuen Univ.
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Fukami Harukazu
Institute For Health Care Science Technological Development Center Suntory Ltd.
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Kurihara H
Institute Of Traditional Chinese Medicine And Natural Products Jinan University
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Tanaka Takaharu
Institute For Fundamental Research Suntory Ltd.
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Fukami Harukazu
Department Of Bioscience And Biotechnology Faculty Of Bioenvironmental Science Kyotogakuen Universit
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Tanaka Takaharu
Institute For Biomedical Research Suntory Ltd.
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Shibata Hiroshi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.:department Of Animal Scienc
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SHIBATA Hiroshi
Institute for Biomedical Research, Suntory Limited
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