Antihypertensive Effects of Chicken Extract against Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats
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概要
- 論文の詳細を見る
We investigated the antihypertensive effect of Brand'S Essence of Chicken(BEC), a popular chicken extract used as a traditional remedy, using deoxycorticosterone acetate(DOCA)-salt hypertensive rats. Animals were unilaterally nephrectomized, and then separated into a sham-operated group(sham group)and a DOCA-salt-treated group. The latter was further separated into a normal diet group and a BEC(freeze-dried powder, 0.1w/w%)-containing diet group. Systolic blood pressre of the normal diet group progressively increased in comparison with that of the sham group. The DOCA-salt-induced hypertension was markedly suppressed by feeding a BEC-containing diet. Systolic blood pressure after 5 weeks was 128±2mmHg in sham group, 181±4mmHg in the DOCA-salt-treated normal diet group and 139±5mmHg in the DOCA-salt-treated BEC diet grotup, respectively. The treatment with DOCA and salt for 5 weeks significantly increased the weights of heart and left ventricle, but these increases were significantly suppressed in the BEC group. When the degree of vascular hypertrophy of the aorta was histochemically evaluated, DOCA-salt-induced increases in wall thickness and wall area of the vessels were significantly decreased by the BEC-feeding. Histopathological renal damage of fibrinoid-Iike necrosis in glomeruli, thickening of small arteries and tubular dilatation were observed in the DOCA-salt-treated normal diet group, but this damage was efficiently reduced by the BEC-feeding. In addition, BEC-feeding decreased urinary excretion of protein, which was elevated by the treatment with DOCA and salt. Thus, BEC seems to be useful as a prophylactic treatment in the development of hypertension and related tissue injuries.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
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KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
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ONO Hiroyuki
Department of Gastroenterology, National Cancer Center Hospital
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MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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Tanaka Tetsuro
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
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Tanaka T
Institute For Health Care Science Suntory Ltd.
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Tanaka Takaharu
Institute For Health Care Science Suntory Ltd.
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Tanaka T
Suntory Consumer Health Products Division
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Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
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Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
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OKUI Tomoko
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Okui T
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Okui Tomoko
Department Of Biology Faculty Of Science Nara Women's University
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Tanaka Takaharu
Institute For Fundamental Research Suntory Ltd.
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Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
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Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
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Ono Hiroyuki
Department Of Research & Development Cerebos Pacific Ltd.
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Tanaka Takaharu
Institute For Biomedical Research Suntory Ltd.
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Ono Hiroyuki
Department Of Electronic Chemistry Interdisciplinary Graduate School Of Science And Engineering Toky
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